Abstract: The instant disclosure is directed to a vaginal care composition that restores pH balance, and thereby reduces vaginal dryness, irritation, dyspareunia, post-coital bleeding, infections, vaginal and pelvic pain and increases vaginal lubrication. In some embodiments, the vaginal care composition comprises stem cell-derived exosomes (e.g., mesenchymal stem cell (MSC)-derived exosomes), an antioxidant and a pH buffer. Another aspect of the disclosure is directed to methods for improving vaginal health by administering the vaginal care composition of the instant disclosure.

Abstract: Provided herein are compositions that are useful in stabilizing and preserving biologic drugs, such as exosomes, during lyophilization. Further provided herein are methods for stabilizing biologic drugs during lyophilization using the compositions of the disclosure.

Abstract: The instant disclosure is directed to a vaginal care composition that restores pH balance, and thereby reduces vaginal dryness, irritation, dyspareunia, post-coital bleeding, infections, vaginal and pelvic pain and increases vaginal lubrication. In some embodiments, the vaginal care composition comprises stem cell-derived exosomes (e.g., mesenchymal stem cell (MSC)-derived exosomes), an antioxidant and a pH buffer. Another aspect of the disclosure is directed to methods for improving vaginal health by administering the vaginal care composition of the instant disclosure.

Abstract: The present disclosure provides, inter alia, formulations for topical treatment of vascular conditions. In certain embodiments, the formulations comprise a delivery system enabling penetration of sympathomimetic agents to the dermis where vasculature including veins and arteries may be treated. The present disclosure also provides methods for treating vascular conditions for which effective topical treatment is currently inadequate or not available. Methods for making such formulations are also provided.