Abstract: The present invention generally relates to processes for preparation of Tezacaftor and pharmaceutical composition comprising the same. The present invention also encompasses novel intermediates of tezacaftor, processes for its preparation and use of said intermediates in the preparation of tezacaftor.

Abstract: A method includes providing a gasifier with a fuel source comprising a heavy oil, a light oil, and recovered soot. The gasifier may gasify the fuel source to generate a syngas and soot. The method also includes recovering the soot in a first separation unit that may receive a portion of the heavy oil and separate the soot from an extraction oil used to recover the soot. The first separation unit generates soot bottoms that include the portion of the heavy oil and the recovered soot. The method also includes flowing a first separation co-fractionate to a second separation unit. The first separation co-fractionate includes the extraction oil and the light oil. The second separation unit may separate the extraction oil and the light oil, and direct the light oil towards the first separation unit.

Abstract: The disclosed embodiments relate to systems for deaerating a stream of slag sump water produced by a gasifier. For example, in one embodiment, a system includes a flash vessel having a first inlet configured to introduce a first fluid into the flash vessel, wherein the flash vessel is configured to flash the first fluid to produce a first flash gas, a second inlet configured to introduce a stream from slag sump into the flash vessel, wherein the stream from slag sump comprises a mixture of a gasification fine slag, dissolved oxygen (O2), and water. A gas-liquid contactor in the flash vessel is configured to contact the stream from slag sump with the first flash gas to enable the first flash gas to deaerate the stream from slag sump. A first outlet of the vessel is configured to output an overhead discharge comprising the first flash gas and oxygen from the stream from slag sump.

Abstract: A method includes providing a gasifier with a fuel source comprising a heavy oil, a light oil, and recovered soot. The gasifier may gasify the fuel source to generate a syngas and soot. The method also includes recovering the soot in a first separation unit that may receive a portion of the heavy oil and separate the soot from an extraction oil used to recover the soot. The first separation unit generates soot bottoms that include the portion of the heavy oil and the recovered soot. The method also includes flowing a first separation co-fractionate to a second separation unit. The first separation co-fractionate includes the extraction oil and the light oil. The second separation unit may separate the extraction oil and the light oil, and direct the light oil towards the first separation unit.

Abstract: The disclosed embodiments relate to systems for deaerating a stream of slag sump water produced by a gasifier. For example, in one embodiment, a system includes a flash vessel having a first inlet configured to introduce a first fluid into the flash vessel, wherein the flash vessel is configured to flash the first fluid to produce a first flash gas, a second inlet configured to introduce a stream from slag sump into the flash vessel, wherein the stream from slag sump comprises a mixture of a gasification fine slag, dissolved oxygen (O2), and water. A gas-liquid contactor in the flash vessel is configured to contact the stream from slag sump with the first flash gas to enable the first flash gas to deaerate the stream from slag sump. A first outlet of the vessel is configured to output an overhead discharge comprising the first flash gas and oxygen from the stream from slag sump.