Abstract: Systems and methods for automated drilling control and optimization are disclosed. Training data, including values of drilling parameters, for a current stage of a drilling operation are acquired. A reinforcement learning model is trained to estimate values of the drilling parameters for a subsequent stage of the drilling operation to be performed, based on the acquired training data and a reward policy mapping inputs and outputs of the model. The subsequent stage of the drilling operation is performed based on the values of the drilling parameters estimated using the trained model. A difference between the estimated and actual values of the drilling parameters is calculated, based on real-time data acquired during the subsequent stage of the drilling operation. The reinforcement learning model is retrained to refine the reward policy, based on the calculated difference. At least one additional stage of the drilling operation is performed using the retrained model.

Abstract: Aspects of the present disclosure relate to projecting control parameters of equipment associated with forming a wellbore, stimulating the wellbore, or producing fluid from the wellbore. A system includes the equipment and a computing device. The computing device is operable to project a control parameter value of the equipment using an equipment control process, and to receive confirmation that the projected control parameter value is within an allowable operating range. The computing device is also operable to adjust the equipment control process based on the confirmation, and to control the equipment to operate at the projected control parameter value. Further, the computing device is operable to receive real-time data associated with the forming of the wellbore, the stimulating of the wellbore, or the producing fluid from the wellbore. Furthermore, the computing device is operable to adjust the equipment control process based on the real-time data.

Abstract: Disclosed herein are methods of detecting a target RNA, methods of diagnosing an individual with a disease or condition when a target RNA associated with the disease or condition is detected, and methods of conveying via a communication medium data from the detection of a target RNA.

Abstract: Disclosed herein are methods of detecting a target RNA, methods of diagnosing an individual with a disease or condition when a target RNA associated with the disease or condition is detected, and methods of conveying via a communication medium data from the detection of a target RNA.