Patents by Inventor Srivari Chandrasekhar
Srivari Chandrasekhar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11932654Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.Type: GrantFiled: February 9, 2021Date of Patent: March 19, 2024Assignee: Council of Scientific & Industrial ResearchInventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
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Publication number: 20230321038Abstract: The present invention relates to compound of Formula 1 for use in treating IPF, by reducing collagen deposition in lungs, attenuating the fibrotic marker's expression (in IPF cell-lines Bleomycin induced rat lungs) and improving the bleomycin induced pathological changes in rat lungs, and ARDS, by reducing the cytokine storm. The invention also relates to compound of Formula 1 for use in treating various fibrotic disorders like lung injuries caused by virus or bacterial infections, cardiac, hepatic and kidney fibrosis.Type: ApplicationFiled: September 3, 2021Publication date: October 12, 2023Inventors: Srivari CHANDRASEKHAR, Prathama S MAINKAR, Chada RAJI REDDY, Sistla RAMAKRISHNA, Andugulapati SAI BALAGI, Kuncha MADHUSUDANA, Muppidi MOHAN VENKATA SUBBARAO, Tirunavalli SATYA KRISHNA
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Publication number: 20220333139Abstract: The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherein, P is H or an alcohol protecting group, n is an integer ranging from 0-12.Type: ApplicationFiled: June 17, 2020Publication date: October 20, 2022Applicant: Council of Scientific and Industrial ResearchInventors: Srivari CHANDRASEKHAR, Subhash GHOSH, Avula Shiva KRISHNA, Chada Raji REDDY, Gangarajula SUDHAKAR, Kumaraguru THENKRISHNAN, Srihari PABBARAJA, Prathama Satyendra MAINKAR, Rajesh NASAM
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Patent number: 11306100Abstract: The present invention provides a compound of general formulae I useful as GSK3? inhibitors and their anticancer potential and process for preparation of these spirooxindoles. wherein Z is hydrogen, halogen, hydroxy, alkoxy, cyano, nitro; Ring A is a five membered or six membered or seven membered optionally containing additional hetero atom in the ring X is optionally CH2 Ring B is triazole or cyclic amine alone or with one or more hetero atoms part of the ring and optionally substituted with one or more substituents Y is hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl or aryl, heteroaryl, wherein these substituents are optionally substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde, wherein these substituents are further substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde.Type: GrantFiled: March 9, 2018Date of Patent: April 19, 2022Inventors: Prathama S. Mainkar, Mohammad Abdul Sattar, Pitchakuntla Mallesham, Togapur Pavan Kumar, Divya Duscharla, Ummanni Ramesh, Srivari Chandrasekhar
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Publication number: 20210284650Abstract: The present invention provides a compound of general formulae I useful as GSK3? inhibitors and their anticancer potential and process for preparation of these spirooxindoles. wherein Z is hydrogen, halogen, hydroxy, alkoxy, cyano, nitro; Ring A is a five membered or six membered or seven membered optionally containing additional hetero atom in the ring X is optionally CH2 Ring B is triazole or cyclic amine alone or with one or more hetero atoms part of the ring and optionally substituted with one or more substituents Y is hydrogen, alkoxy, aryloxy, hydroxy, ester, amide, amino, alkyl or aryl, heteroaryl, wherein these substituents are optionally substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde, wherein these substituents are further substituted with one or more halogen, hydroxy, alkoxy, alkyl, aryl, heteroaryl, aryloxy, nitro, cyano, ester, aldehyde.Type: ApplicationFiled: March 9, 2018Publication date: September 16, 2021Inventors: Prathama S. MAINKAR, Mohammad Abdul SATTAR, Pitchakuntla MALLESHAM, Togapur Pavan KUMAR, Divya DUSCHARLA, Ummanni RAMESH, Srivari CHANDRASEKHAR
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Publication number: 20210171538Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.Type: ApplicationFiled: February 9, 2021Publication date: June 10, 2021Applicant: Council of Scientific & Industrial ResearchInventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
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Patent number: 10947249Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.Type: GrantFiled: October 26, 2018Date of Patent: March 16, 2021Inventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
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Patent number: 10421739Abstract: The present invention relates to a process for the preparation of racemic nicotine from 3-pyridylaldehyde using a one-pot or step-wise method. The process comprises the following steps: Stetter reaction, reduction-cyclization and methylation.Type: GrantFiled: January 6, 2017Date of Patent: September 24, 2019Assignee: Council of Scientific & Industrial ResearchInventors: Prathama Satyendra Mainkar, Kondepudi Sugnana Sunder, Togapur Pavan Kumar, Srivari Chandrasekhar
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Publication number: 20190211027Abstract: The present invention relates to nimbolide analogs useful as anti-cancer agents and preparation thereof. Particularly the present invention relates to nimbolide analogs of general formula I. wherein, ring M is any ring selected from the group consisting of substituted or unsubstituted aryl, heteroaryl, cycloalkyl and heterocyclic; A and B are selected from the group consisting of C, O, N, S and H; R1, R2, R3, R4, R5 and R6 are selected from the group consisting of C1-C6 alkyl, aryl, heteroaryl, C1-C7 cycloalkyl, heteroalkyl, hydrogen, hydroxy, alkoxy, nitro, halogen, amino, alkylamino, aryl amino and cyano; wherein each of these groups may be further substituted with one or more substituents selected from the group consisting of hydrogen, hydroxy, halogen, cyano, alkyl amino, aryl amino, alkoxy, amino, nitro, aldehyde, carboxylic acid and ester.Type: ApplicationFiled: October 26, 2018Publication date: July 11, 2019Applicant: Council of Scientific & Industrial ResearchInventors: Srivari Chandrasekhar, Prathama Satyendra Mainkar, Karre Nagaraju, Togapur Pavan Kumar, Ummanni Ramesh, Kanchanapally Tejaswini, Jerald Mahesh Kumar, Katragadda Suresh Babu, Boggavarapu Subrahmanya Sastry, Debabrata Mukhopadhyay
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Publication number: 20190016699Abstract: The present invention relates to a process for the preparation of racemic nicotine from 3-pyridylaldehyde using a one-pot or step-wise method. The process comprises the following steps: Stetter reaction, reduction-cyclisation and methylation.Type: ApplicationFiled: January 6, 2017Publication date: January 17, 2019Applicant: Council of Scientific & Industrial ResearchInventors: Prathama Satyendra Mainkar, Kondepudi Sugnana Sunder, Togapur Pavan Kumar, Srivari Chandrasekhar
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Patent number: 7179937Abstract: The invention relates to the use of derivatives of cyclopentenone for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of derivatives of cyclopentenone for the inhibition and/or prevention of cancer of the colon, pancreas, larynx, ovary, duodenum, kidney, oral cavity, prostate, lung, endothelial cells and leukemias.Type: GrantFiled: December 4, 2002Date of Patent: February 20, 2007Assignee: Dabur Research FoundationInventors: Mukund K. Gurjar, Radhika D. Wakharkar, Gautam R. Desiraju, Ashwini Nangia, Jhillu Singh Yadav, Anand C. Burman, Rama Mukherjee, Hanumant Bapu Rao Borate, Srivari Chandrasekhar, Manu Jaggi, Anuo T. Singh, Kamal Kapoor, Sanjay Sarkhel, K. V. V. M. Sairam
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Publication number: 20030229146Abstract: The invention relates to the use of derivatives of cyclopentenone for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds.Type: ApplicationFiled: December 4, 2002Publication date: December 11, 2003Applicant: DABUR RESEARCH FOUNDATIONInventors: Mukund K. Gurjar, Radhika D. Wakharkar, Gautam R. Desiraju, Ashwini Nangia, J. S. Yadav, Anand C. Burman, Rama Mukherjee, Hanumant Bapurao Borate, Srivari Chandrasekhar, Manu Jaggi, Anuo T. Singh, Kamal K. Kapoor, Sanjay Sarkhel, Kalapatapu V.V.M. Sairam