Abstract: The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).

Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.

Abstract: Provided herein are CD70-binding proteins comprising a CD70-binding domain and a transmembrane domain, engineered immune cells comprising the CD70-binding proteins, and methods of making and using the same. Also provided herein are engineered immune cells e.g. CAR (chimeric antigen receptor) T cells for administration to patients to treat cancer (e.g., solid tumors and hematologic tumors) and other unwanted conditions. The cells are engineered to functionally express a first antigen binding molecule e.g. a CD70 CAR and a second antigen binding molecule e.g. a second CAR that binds a target molecule characteristic of the cancer or other disease or unwanted condition. The cells may be further engineered to reduce the functional expression level of one or more of TRAC, CD52 and CD70. Also provided are methods of making and using the engineered cells, compositions and kits comprising them, and methods of treating by administering them.

Abstract: The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).

Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.

Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.

Abstract: The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).

Abstract: Markup language inputs are received for generating a markup language description of an item to be rendered. The markup language inputs include in-line metadata describing a transformation to be performed on a data item before it is rendered. The markup language description, including the in-line metadata describing the transformation, is generated and presented for transformation and rendering.

Abstract: A uniform approach for web service discovery is provided through common auto-discovery logic for cloud-based or enterprise-based deployments for a specific web service. Appropriate credentials may be applied employing a uniform method using an appropriate authentication scheme for on-premise, fully hosted, or partially hosted auto-discovered web services. A common interface may be implemented even if the protocols for discovery differ from service to service or between cloud-based deployment and enterprise-based deployment for the same service. Web service locations auto-discovered through different protocols may be cached for subsequent use.

Abstract: Markup language inputs are received for generating a markup language description of an item to be rendered. The markup language inputs include in-line metadata describing a transformation to be performed on a data item before it is rendered. The markup language description, including the in-line metadata describing the transformation, is generated and presented for transformation and rendering.

Abstract: An asset collection service is provided through a capture of content provided by an external source. A capture management application detects a user selection to create the capture of a portion of the content. The capture is created from the portion by inserting a reference to an asset into the capture, where the asset is located within the portion. The asset is fetched from the external resource using the reference. Additionally, the reference is replaced with the fetched asset within the capture.

Abstract: Multiple instances of an incoming call in a unified communication system capable of communicating through multiple networks are provided to devices and/or applications associated with the called party. Upon acceptance or a global rejection of the incoming call through one of the end devices/applications, the remainder are provided a cancellation notice for the forked call request that includes information associated with which end device took the action, what type of action was taken, whether the action was based on automatic policy implementation.

Abstract: The entry and transmission of notes to recipients along the conversation chain. Notes can be created based on an incoming caller. The notes can be transmitted to the conversation recipient for viewing before, during, and after the recipient accepts the conversation. This is facilitated by a communications client that operates to allow entry of the notes, and forwarding of the call recipient via a SIP framework. Moreover, notes previously taken and/or information provided manually and/or automatically by the communications system can be provided to an agent (e.g., ACD, receptionist) receiving the conversation, at any point in the conversation chain for quick identification not only of the conversation source but of previous information already collected.

Abstract: A pluggable token provider model for message level authentication across multiple web services is provided. Web service and token provider implementations within a client application are separated from an actual component that operates the business logic to formulate and understand a web request. The web service components may request web services to be executed and supply the body for the web service message while a common framework maintains the web services metadata, which includes definitions associated with respective tokens. The framework may further maintain token provider implementations that actually fetch authentication tokens and perform the web requests.

Abstract: Disclosed herein are embodiments for validating a user joining a conferencing session. According to various embodiments, a first identifier is received. A user is identified from a plurality of users based at least in part on the first identifier. A second identifier is received that corresponds to the first identifier and the user and the user is validated based on both the first identifier and the second identifier. The user may then join the conferencing session, with the user's identity being revealed to others attending the conferencing session.

Abstract: Service invocation information including call routing, reasons for redirections, and similar information are provided to party requesting a communication session and recipients of an enhanced communication system along the call routing path as the request is routed. Some of the information is filtered based on system and/or user defined rules, user permission levels, and comparable aspects.

Abstract: Subscribers of an enhanced communication system are enabled to indicate invocation or clearing of media specific features such as music-on-hold or video-on-hold. The invocation or clearing is transmitted to participating end points as a Session Initiation Protocol (SIP) re-INVITE message with Session Description Protocol (SDP) attribute descriptions identifying the feature, applicable media channels and whether the message is for invocation or clearing of the feature.

Abstract: Disclosed herein are embodiments for validating a user joining a conferencing session. According to various embodiments, a first identifier is received. A user is identified from a plurality of users based at least in part on the first identifier. A second identifier is received that corresponds to the first identifier and the user and the user is validated based on both the first identifier and the second identifier. The user may then join the conferencing session, with the user's identity being revealed to others attending the conferencing session.

Abstract: Multiple instances of an incoming call in a unified communication system capable of communicating through multiple networks are provided to devices and/or applications associated with the called party. Upon acceptance or a global rejection of the incoming call through one of the end devices/applications, the remainder are provided a cancellation notice for the forked call request that includes information associated with which end device took the action, what type of action was taken, whether the action was based on automatic policy implementation.

Abstract: Disclosed herein are embodiments for validating a user joining a conferencing session. According to various embodiments, a first identifier is received. A user is identified from a plurality of users based at least in part on the first identifier. A second identifier is received that corresponds to the first identifier and the user and the user is validated based on both the first identifier and the second identifier. The user may then join the conferencing session, with the user's identity being revealed to others attending the conferencing session.