Patents by Inventor Stanislav Kazda

Stanislav Kazda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridinylmethyl-substituted pyridines and pyridones
    Patent number: 5414003
    Abstract: Pyridinylmethyl-substituted pyridines and pyridones are prepared by reacting pyridine- or pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substances according to the invention can be used as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: May 9, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Fey, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Thomas Kramer, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Siegfried Zaiss
  • Biphenylmethyl-substituted pyridones
    Patent number: 5407942
    Abstract: Biphenylmethyl-substituted pyridones are prepared by reaction of pyridones with appropriate biphenylmethyl compounds.The biphenylmethyl-substituted pyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: May 5, 1993
    Date of Patent: April 18, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Dressel, Peter Fey, Rudolf H. Hanko, Walter Hubsch, Thomas Kramer, Ulrich E. Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil, Andreas Knorr, Johannes-Peter Stasch
  • Substituted mono- and bipyridylmethylpyridones
    Patent number: 5407948
    Abstract: Substituted mono- and bipyridylmethylpyridones are prepared either by reaction of pyridones with mono- or bipyridylmethylhalogen compounds or by reaction of pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substituted mono- and bipyridylmethylpyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: May 6, 1994
    Date of Patent: April 18, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Fey, Walter Hubsch, Jurgen Dressel, Rudolf Hanko, Thomas Kramer, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Siegfried Zaiss
  • Propenoyl-imidazole derivatives
    Patent number: 5376671
    Abstract: Propenoyl-imidazole derivatives are prepared by reaction of appropriate imidazoylaldehydes with CH-acidic compounds and subsequent dehydration of the intermediates. The propenoyl-imidazole derivatives can be employed as active compounds in medicaments for the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: April 6, 1993
    Date of Patent: December 27, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Matthias Muller-Gliemann, Jurgen Dressel, Peter Fey, Rudolf Hanko, Walter Hubsch, Thomas Kramer, Ulrich Muller, Martin Beuck, Stanislav Kazda, Andreas Knorr, Johannes-Peter Stasch, Stefan Wohlfeil
  • Sulphonylbenzyl-substituted imidazopyridines
    Patent number: 5364942
    Abstract: Sulphonylbenzyl-substituted imidazopyridines can be prepared by reacting correspondingly substituted imidazopyridines with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted imidazopyridines can be employed as active compounds in medicaments, in particular for the treatment of hypertension and atherosclerosis.
    Type: Grant
    Filed: February 18, 1993
    Date of Patent: November 15, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Hanko, Jurgen Dressel, Peter Fey, Walter Hubsch, Thomas Kramer, Ulrich E. Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Claudia Hirth-Dietrich, Andreas Knorr, Johannes-Peter Stasch, Stefan Wohlfeil, Ozkan Yalkinoglu
  • Substituted biphenylpyridones
    Patent number: 5356911
    Abstract: Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.
    Type: Grant
    Filed: November 2, 1992
    Date of Patent: October 18, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Stefan Wohlfeil, Walter Hubsch, Jurgen Dressel, Peter Fey, Rudolf Hanko, Thomas Kramer, Ulrich Muller, Siegfried Zaiss
  • Sulfonylbenzyl-substituted benzo- and pyridopyridones
    Patent number: 5354749
    Abstract: Sulfonylbenzyl-substituted benzo- and pyridopyridones are prepared by reacting corresponding benzo- and pyridopyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted benzo- and pyridopyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hyper tension and atherosclerosis.
    Type: Grant
    Filed: May 5, 1993
    Date of Patent: October 11, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Dressel, Peter Fey, Rudolf H. Hanko, Walter Hubsch, Thomas Kramer, Ulrich E. Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil, Andreas Knorr, Johannes-Peter Stasch
  • Substituted phenylacetamides
    Patent number: 5352687
    Abstract: Substituted phenylacetamides can be prepared by reaction of appropriately substituted phenylacetic acids with imidazoles and subsequent amidation. The substituted phenylacetic acid derivatives can be employed in medicaments for the treatment of high blood pressure and atherosclerosis.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: October 4, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich E. Muller, Matthias Muller-Gliemann, Jurgen Dressel, Peter Fey, Rudolf Hanko, Walter Hubsch, Thomas Kramer, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil, Ozkan Yalkinoglu, Andreas Knorr, Johannes-Peter Stasch
  • Sulphonylbenzyl-substituted imidazoles
    Patent number: 5318980
    Abstract: Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary manner.The sulphonylbenzyl-substituted imidazoles can be used as active compounds in medicaments.
    Type: Grant
    Filed: February 18, 1993
    Date of Patent: June 7, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Hanko, Jurgen Dressel, Peter Fey, Walter Hubsch, Thomas Kramer, Ulrich E. Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Claudia Hirth-Dietrich, Andreas Knorr, Johannes-Peter Stasch, Stefan Wohlfeil, Ozkan Yalkinoglu
  • Imidazolyl-propenoic acid derivatives
    Patent number: 5294633
    Abstract: Imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes with phosphonoacetic acid esters. The imidazolyl-propenoic acid derivatives are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.
    Type: Grant
    Filed: September 21, 1992
    Date of Patent: March 15, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Kramer, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Stefan Wohlfeil
  • Sulphonylbenzyl-substituted pyridones which are angiotension II receptor antagonists
    Patent number: 5254543
    Abstract: Sulphonylbenzyl-substituted pyridones can be prepared by reacting pyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted pyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: February 18, 1993
    Date of Patent: October 19, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Hanko, Walter Hubsch, Jurgen Dressel, Peter Fey, Thomas Kramer, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Claudia Hirth-Dietrich, Andreas Knorr, Johannes-Peter Stasch, Stefan Wohlfeil, Ozkan Yalkinoglu
  • Cyclic-substituted imidazolyl-propenoic acid derivatives
    Patent number: 5225428
    Abstract: Cyclic-substituted imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes and subsequent elimination of water. The cyclic-substituted imidazolylpropenoic acid derivates are suitable as active substances in medicaments, in particular for the treatment of high blood pressure and atherosclerosis.
    Type: Grant
    Filed: September 21, 1992
    Date of Patent: July 6, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Kramer, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Stefan Wohlfeil
  • Amino-esters of dihydropyridines useful for improving circulation in patients
    Patent number: 5063239
    Abstract: Circulation active compounds of the formula ##STR1## in which R.sup.1 is phenyl or heterocyclyl substituted by nitro, trifluoromethyl or other radicals,R.sup.2 is optionally substituted alkyl or other radicalR.sup.3 and R.sup.5 are hydrogen, methyl or other radicals,R.sup.4 is hydrogen or optionally substituted alkyl,X is from 2 to 15, andR.sup.6 is ##STR2## and physiologically acceptable salts thereof.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: November 5, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Eckhard Schwenner, Hartmut Stegelmeier, Stanislav Kazda, Andreas Knorr
  • Optically active 1,4-dihydropyridine esters useful for treating circulatory illnesses
    Patent number: 4988717
    Abstract: The invention relates to optically active 1,4-dihydropyridine compounds of Formulas Ia and Ib as defined hereinabove which are effective for influencing circulation. Also included in the invention are compositions containing said optically active compounds and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: March 30, 1989
    Date of Patent: January 29, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Friedrich Bosseret, Wulf Vater, Robertson Towart, Kurt Stoepel, Stanislav Kazda
  • Medicament formulation containing dihydropyridines and a process for its preparation
    Patent number: 4976964
    Abstract: In the parenteral administration of a dihydropyridine, the improvement which comprises administering the dihydropyridine in an aqueous medium of pH 3 to 8.5 having dispersed therein liposomes with an average diameter of 20-1000 nm, the liposome membrane containng the following constituents by weight:(a) a part of a dihydropyridine, and(b) 5-500 parts of lipids.The aqueous medium is storage stable and readily injectable.
    Type: Grant
    Filed: April 16, 1986
    Date of Patent: December 11, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Schlossmann, Alfred Zembrod, Stanislav Kazda, Peter Serno, Bernd Klinksiek
  • Amino-esters of dihydropyridines, and their use as circulatory agents for treating ischaemic heart diseases
    Patent number: 4950676
    Abstract: Circulation active compounds of the formula ##STR1## in which R.sup.1 is phenyl or heterocyclyl substituted by nitro, trifluoromethyl or other radicals,R.sup.2 is optionally substituted alkyl or other radicalR.sup.3 and R.sup.5 are hydrogen, methyl or other radicals,R.sup.4 is hydrogen or optionally substituted alkyl,X is from 2 to 15, andR.sup.6 is ##STR2## and physiologically acceptable salts thereof.
    Type: Grant
    Filed: March 1, 1989
    Date of Patent: August 21, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Eckhard Schwenner, Hartmut Stagelmeier, Stanislav Kazda, Andreas Knorr
  • Certain 2h-benzo[a]quinolizin-2-yl-aminoalkyl esters of 1,4-dihydro-3,5-pyridinedicarboxylates useful for treating circulation disorders
    Patent number: 4861782
    Abstract: Circulation active compounds of the formula ##STR1## in which R.sup.1 is phenyl or heterocyclyl substituted by nitro, trifluoromethyl or other radicals,R.sup.2 is optionally substituted alkyl or other radicalR.sup.3 and R.sup.5 are hydrogen, methyl or other radicals,R.sup.4 is hydrogen or optionally substituted alkyl,X is from 2 to 15, andR.sup.6 is ##STR2## and physiologically acceptable salts thereof.
    Type: Grant
    Filed: February 25, 1987
    Date of Patent: August 29, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Eckhard Schwenner, Hartmut Stegelmeier, Stanislav Kazda, Andreas Knorr
  • Antihypertensive combination products containing a dihydropyridine and a pyridazodiazepine
    Patent number: 4859665
    Abstract: Compositions for treating hypertension comprising an effective amount of a dihydropyridine of the formula ##STR1## in which X is 1 or 2 identical or different substituents from the group consisting of nitro, chlorine and trifluoromethyl, or together with the phenyl ring, the group ##STR2## R.sup.1 is alkyl of 1 to 4 C atoms, which is optionally substituted by alkoxy of 1 to 4 C atoms,R.sup.2 is alkyl of 1 to 12 C atoms, which is optionally substituted by alkoxy of 1 to 3 C atoms, fluorine or N-methyl-N-benzylamino andR.sup.3 is alkyl of 1 to 4 C atoms, cyano or hydroxymethyl, and a pyridazodiazepine of the formula ##STR3## in which R.sup.4 is aralkyl,R.sup.5 is hydrogen or alkyl of 1 to 8 C atoms,R.sup.6 is hydrogen or alkyl of 1 to 8 C atoms andR.sup.7 and R.sup.8 are hydrogen, or together, an oxo group, are described.
    Type: Grant
    Filed: December 2, 1986
    Date of Patent: August 22, 1989
    Assignees: Hoffmann-LaRoche Inc., Bayer Akt.
    Inventors: Bernward Garthoff, Marcel Gerold, Fridolin Hefti, Stanislav Kazda, Andreas Knorr
  • The compound, (.revreaction.)1,4-dihydro-2,6-dimethyl-4-(2'-nitrophenyl)-pyridine-3,5- dicarboxylic acid, methyl isobutyl ester, compositions containing same and a method for effecting coronary dilation
    Patent number: 4849433
    Abstract: The invention relates to optically active 1,4-dihydropyridine compounds of Formulas Ia and Ib as defined hereinabove which are effective for influencing circulation. Also included in the invention are compositions containing said optically active compounds and methods for the use of said compounds and compositions.
    Type: Grant
    Filed: February 9, 1987
    Date of Patent: July 18, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Egbert Wehinger, Horst Meyer, Friedrich Bossert, Wulf Vater, Robertson Towart, Kurt Stoepel, Stanislav Kazda
  • Circulation active methionine-substituted 1,4-dihydropyridines
    Patent number: 4808622
    Abstract: Circulation active, e.g. antihypertensive novel methionine-substituted dihydropyridines of the formula ##STR1## in which R.sup.1 is phenyl or a heterocyclic radical, or a physiologically acceptable salt thereof.
    Type: Grant
    Filed: January 7, 1987
    Date of Patent: February 28, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunther Kinast, Eckhard Schwenner, Stanislav Kazda, Andreas Knorr, Michael Kayser