Abstract: The present disclosure relates to methods for using BCMA-specific binding molecules (such as a BCMA-specific chimeric antigen receptor or antibody) in combination with ?-secretase inhibitors, which can be done concurrently or sequentially, to treat or prevent a B-cell related proliferative disease, such as a cancer or autoimmune disease, or the like. A BCMA-specific binding molecule in combination with ?-secretase inhibitor can be used in, for example, adoptive immunotherapy.

Abstract: The invention relates to a system for manufacturing a plurality of integrated circuits, IC, mounted on a common support, the system comprising: an input station configured (adapted, arranged) to receive at least one common support; an output station configured (adapted, arranged) to receive at least one common support having a plurality of integrated circuits formed thereon; a plurality of processing modules each module being operable (configured, arranged, adapted) to perform at least one of the processing steps (e.g. deposition, patterning, etching) for forming an integrated circuit on the common support; a transfer means operable (configured, arranged, adapted) to transfer the at least one common support from the input station to the output station and to one or more of the processing modules therebetween; control means (e.g.

Abstract: A van is provided within its carrying compartment with an installation for use in the safe storage against theft of tradesmen's tools, such, for example, as electric drills. The installation comprises a substantially L-shaped frame, and several panels hingedly connected to the frame for movement between a collapsed, non obtrusive state in which chamber front and side panels are prostrate on, or adjacent to the compartment floor, and an erect state in which these are able to cooperated with a lid panel also hinged to the frame to create the chamber.

Abstract: A van is provided within its carrying compartment with an installation for use in the safe storage against theft of tradesmen's tools, such, for example, as electric drills. The installation comprises a substantially L-shaped frame, and several panels hingedly connected to the frame for movement between a collapsed, non obtrusive state in which chamber front and side panels are prostrate on, or adjacent to the compartment floor, and an erect state in which these are able to cooperated with a lid panel also hinged to the frame to create the chamber.

Abstract: A lens element for a vehicle lamp, e.g. a direction indicator lamp, consists of a molded transparent plastic body provided with parallel rows of projections each of which has the form of part of a body of revolution of a cylindrical mid-region and end regions which each have the form of part of the body of revolution of the mid-region.In order to produce the required light output in the direction of the longitudinal axis of the vehicle in the case where the lens element is used in a lamp assembly having a relatively inefficient reflector, the lens element is provided with a plurality of ribs which extend parallel to the rows of projections and which are longer than the projections. The ribs preferably alternate with the rows of projections and may extend for the whole or only part of the length of the lens element.

Abstract: A lamp assembly, particularly intended for use on a motor vehicle, comprises a reflector which receives a light bulb, and a first lens element which overlies the reflector and which has formed on one surface thereof a multiplicity of individual lenses. A baffle is secured to the opposite surface of the first lens element, and includes a multiplicity of light-transmitting portions each of which is disposed on the optical axis of a respective one of the individual lenses and whose extent is limited to that necessary to transmit substantially the whole of a pencil of light rays which is focussed by the respective individual lens. The remainder of the baffle is light-obstructing. A second lens element overlies the first lens element and the baffle, and also includes a multiplicity of individual lenses which are in no particular registration with the individual lenses of the first lens element.

Abstract: A mould for producing a lamp lens element comprises a mould plate having a plurality of recesses in one face thereof. Each recess is adapted to produce a projection on one face of the lens element produced from the mould, and is shaped so as to define in the projection a lens integral with and overlying a prism. In one embodiment, each recess has a concave part-spherical surface portion whose axis is inclined to the perpendicular to the general plane of the said one face of the mould plate. Alternatively, each recess is in the form of an elongate groove having a part-cylindrical mid-region whose axis is inclined relative to the general plane of the said one face of the mould plate. In the latter case, the groove also has part-spherical end regions whose axes are each either perpendicular to the said general plane or inclined at an acute angle to the perpendicular to the general plane.

Abstract: A lamp assembly comprises a hollow body having two recesses therein, a bulbholder and a reflector in each recess, and a colorless transparent lens extending across the openings of the recesses. In one of the recesses is mounted a standard bulb and a filter element in the form of a domed cover surrounding the bulb. A neutrally colored light-absorbing material is incorporated into the filter element or is provided as a layer over a surface thereof remote from the bulb.

Abstract: A motor vehicle rear lighting system comprises first and second lamp filaments in a single bulb envelope, the first lamp filament having a greater resistance than that of the second lamp filament. One or more electrical switches are operable, in one position, to connect the lamp filaments in series with a battery, and, in another position, to complete the circuit from the battery to the second lamp filament without the first lamp filament in series therewith. The arrangement is such that, in said one position of the one or more switches, the first lamp filament becomes luminous and, in said another position of the switch means, the second lamp filament becomes luminous. In one embodiment, a first lamp filament by-pass is provided and, in said another position of the electrical switch, the circuit to the second lamp filament is completed via the by-pass. In another embodiment, the electrical switches are arranged to connect the lamp filaments in parallel when the switches are in their said another position.