Patents by Inventor Stanley J. Stachelek

Stanley J. Stachelek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMPLANTABLE MEDICAL DEVICES THAT ARE RESISTANT TO IMMUNE CELL MEDIATED SURFACE DAMAGE
    Publication number: 20150306284
    Abstract: Methods for protecting biomaterials comprise attaching CD47 or Ig domain thereof to the surface of the biomaterial, thereby inhibiting or reducing immune cell attachment and/or immune cell-mediated damage to the biomaterial. Also provided are kits for practicing these methods and the protected biomaterials.
    Type: Application
    Filed: July 2, 2015
    Publication date: October 29, 2015
    Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Stanley J. STACHELEK, Dennis DISCHER, Robert J. LEVY, Richard TSAI
  • DEVICES AND METHODS FOR PREVENTING PLATELET ACTIVATION
    Publication number: 20150079142
    Abstract: Methods for inhibiting a biomaterial-associated thrombotic event comprise reducing the number of platelets that bind to the biomaterial, or inhibiting platelet activation, by attaching CD47 or the Ig domain thereof to the surface of the biomaterial. Methods of the present invention inhibit thrombi formation on or near a biomaterial that is on the surface of an implant, medical device, tube, or therapeutic delivery vehicle. Also provided are kits for practicing these methods and the modified biomaterials.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 19, 2015
    Inventors: Stanley J. Stachelek, Matthew J. Finley, Robert J. Levy
  • Photo-activated attachment of cholesterol to polyurethane surfaces for adhesion of endothelial cells
    Patent number: 8618242
    Abstract: A polymer is provided according to structure I wherein Y is a thiol-reactive group and Z is an ionogenic group. The surface of a polymeric substrate is modified by contacting the surface with a polymer according to structure II or structure III and exposing the surface to ultraviolet light, optionally followed by contacting the modified surface with the polymer according to structure I.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: December 31, 2013
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Ivan Alferiev, Stanley J. Stachelek
  • Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof
    Patent number: 8465542
    Abstract: A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: June 18, 2013
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Ivan Alferiev, Stanley J. Stachelek
  • STEROID LIPID-MODIFIED POLYURETHANE AS AN IMPLANTABLE BIOMATERIAL, THE PREPARATION AND USES THEREOF
    Publication number: 20120316295
    Abstract: A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.
    Type: Application
    Filed: June 4, 2012
    Publication date: December 13, 2012
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Ivan Alferiev, Stanley J. Stachelek
  • LIGAND-SPECIFIC INHIBITION OF ATTACHMENT OF IMMUNE CELLS TO IMPLANTABLE BIOMATERIALS
    Publication number: 20120251586
    Abstract: Methods for protecting biomaterials comprise attaching CD47 or Ig domain thereof to the surface of the biomaterial, thereby inhibiting or reducing immune cell attachment and/or immune cell-mediated damage to the biomaterial. Also provided are kits for practicing these methods and the protected biomaterials.
    Type: Application
    Filed: April 9, 2010
    Publication date: October 4, 2012
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Stanley J. Stachelek, Dennis Discher, Robert J. Levy, Richard Tsai
  • Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof
    Patent number: 8193290
    Abstract: A modified polyurethane including a lipid substituent from at least one urethane nitrogen and/or at least carbon atom of the modified polyurethane.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: June 5, 2012
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Ivan Alferiev, Stanley J. Stachelek
  • Photo-Activated Attachment Of Cholesterol To Polyurethane Surfaces For Adhesion Of Endothelial Cells
    Publication number: 20120089222
    Abstract: A polymer is provided according to structure (I) wherein Y is a thiol-reactive group selected from one or more of the following moieties and Z is an ionogenic group selected from one or more of the following moieties. The surface of a polymeric substrate is modified by contacting the surface with a polymer according to structure II or structure III and exposing the surface to ultraviolet light.
    Type: Application
    Filed: April 9, 2010
    Publication date: April 12, 2012
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Robert J. Levy, Ivan Alferiev, Stanley J. Stachelek
  • STEROID LIPID-MODIFIED POLYURETHANE AS AN IMPLANTABLE BIOMATERIAL, THE PREPARATION AND USES THEREOF
    Publication number: 20090010984
    Abstract: A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.
    Type: Application
    Filed: June 20, 2008
    Publication date: January 8, 2009
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Robert J. LEVY, Ivan ALFERIEV, Stanley J. STACHELEK
  • Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof
    Patent number: 7408014
    Abstract: A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: August 5, 2008
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Robert J. Levy, Ivan Alferiev, Stanley J. Stachelek