Abstract: Methods are provided for generating an airfoil including an aerodynamically-shaped fillet. 2D fillet curve offset values are defined by obtaining a 2D airfoil image having airfoil surface line and transition region interconnecting airfoil surface line to flowpath surface line with 2D fillet curve. Flowpath offset lines are generated on image at predetermined flowpath offset values and, in the transition region, graphically represent a flowpath offset surface. Intersection point between 2D fillet curve and each flowpath offset line is determined Distance between airfoil surface line and each intersection point generates airfoil offset values. Airfoil and flowpath offset surfaces according to airfoil offset values and flowpath offset values respectively and 3D fillet streamline curves are generated on computer model to define the aerodynamically-shaped fillet. Each 3D fillet streamline curve is an intersection between the airfoil and flowpath offset surfaces.

Abstract: The invention involves various embodiments of a method for treating a human being for a condition associated with (1) seizures, myoclonic seizures, epilepsy, refractory epilepsy, hyperkinetic movements or tremors of hands or feet, (2) a state of ataxia, (3) accumulation of neuronal autofluorescent storage bodies in lysosomes or neurons, or regression of motor development, and (4) low alertness, dementia or mental retardation. The method involves administering a therapeutically effective salt of N-6-trimethyl-L-lysine.

Abstract: A compressor disk for a turbine engine includes a plurality of blades mounted about the circumference. To assemble the blades onto the disk a lock assembly is inserted within a blade slot on the disk. A blade is assembled into the blade slot and slider seals are inserted between the blade and the disk to limit air from entering the blade slot. Additional blades are assembled until the end of the slider seals are reached. The process is repeated until all the blades have been assembled onto the disk. After the last blade has been assembled a spacer seal is placed at each lock assembly to take up the slack. Once all the blades and spacer seals are assembled the lock assemblies can be moved to a locked position.

Abstract: The invention provides a method of synthesis of N-6-trimethyl-L-lysine (TML) derivative compounds for potential treatment of disorders resulting from deficiencies in the TML-carnitine pathway. The invention also provides a method of purification of TML and TML derivative compounds. The treatment of conditions of the diseases late infantile neuronal ceroid lipofuscinosis (LINCL) and neuronal ceroid lipofuscinosis (NCL) with TML were shown in the original parent application.

Abstract: The invention involves various embodiments of a method for treating a human being for a condition associated with (1) a clinical state of impairment of carnitine or carnitine esters, or decreased fatty acid metabolism, (2) low energy production or lower ATP production, (3) clinical hyperammonemia, and (4) clinically high pyruvate levels resulting from a deficiency in the biosynthesis of carnitine. The method involves administering a therapeutically effective salt of N-6-trimethyl-L-lysine.

Abstract: The invention involves various embodiments of a method for treating a human being for a condition associated with (1) a clinical state of impairment of carnitine or carnitine esters, or decreased fatty acid metabolism, (2) low energy production or lower ATP production, (3) clinical hyperammonemia, and (4) clinically high pyruvate levels resulting from a deficiency in the biosynthesis of carnitine. The method involves administering a therapeutically effective salt of N-6-trimethyl-L-lysine.

Abstract: The invention provides a method of synthesis of N-6-trimethyl-L-lysine (TML) derivative compounds for potential treatment of disorders resulting from deficiencies in the TML-carnitine pathway. The invention also provides a method of purification of TML and TML derivative compounds. The treatment of conditions of the diseases late infantile neuronal ceroid lipofuscinosis (LINCL) and neuronal ceroid lipofuscinosis (NCL) with TML were shown in the original parent application.

Abstract: The invention provides derivative compounds of N-6-trimethyl-L-lysine (TML) for potential treatment of disorders resulting from deficiencies in the TML-carnitine pathway. The invention also provides a method of purification of TML and TML derivative compounds. The treatment of conditions of the diseases late infantile neuronal ceroid lipofuscinosis (LINCL) and neuronal ceroid lipofuscinosis (NCL) with TML were shown in the original parent application.

Abstract: The invention involves various embodiments of a method for treating a human being for a condition associated with (1) seizures, myoclonic seizures, epilepsy, refractory epilepsy, hyperkinetic movements or tremors of hands or feet, (2) a state of ataxia, (3) accumulation of neuronal autofluorescent storage bodies in lysosomes or neurons, or regression of motor development, and (4) low alertness, dementia or mental retardation. The method involves administering a therapeutically effective salt of N-6-trimethyl-L-lysine.

Abstract: The invention provides compositions for and methods of treating a number of disorders. In one embodiment, the invention provides a method of treating a wide range of conditions by administering to a human being in need of such treatment, a therapeutically effective amount of (a) N-6-trimethyl-L-lysine of at least 98% purity, (b) a prodrug thereof, (c) an aliphatic chain derivative thereof, (d) an ester derivative thereof, (e) an amide derivative thereof, or (f) a pharmaceutically acceptable salt of said N-6-trimethyl-L-lysine or said prodrug.

Abstract: A compressor disk for a turbine engine includes a plurality of blades mounted about the circumference. To assemble the blades onto the disk a lock assembly is inserted within a blade slot on the disk. A blade is assembled into the blade slot and sliders seals are inserted between the blade and the disk to limit air from entering the blade slot. Additional blades are assembled until the end of the slider seals are reached. The process is repeated until all the blades have been assembled onto the disk. After the last blade has been assembled a spacer seal is placed at each lock assembly to take up the slack. Once all the blades and spacer seals are assembled the lock assemblies can be moved to a locked position.