Abstract: A tamper-indicating, self-sealing disposable pouch is disclosed which is readily adaptable for use for sterilization and sterility maintenance of medical articles and the like. The pouch includes first and second coextensive webs which are at least partially joined together to define the interior of the pouch. The pouch defines an access opening through which the contents of the pouch can be inserted therein, with the pouch uniquely including a laminate adhesive structure in association with the access opening for effecting closing and sealing thereof. The adhesive structure comprises an adhesive carrier member having first and second layers of adhesive on opposite surfaces thereof.