Patents by Inventor Stanley Stein

Stanley Stein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9999596
    Abstract: Formulations and methods for their preparation including a hydrogel including a crosslinked matrix comprising a polymer, and a one or more liposomes containing a therapeutic agent.
    Type: Grant
    Filed: March 12, 2015
    Date of Patent: June 19, 2018
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Stanley Stein, Anita Lalloo
  • Publication number: 20170136087
    Abstract: A multifunctional polyethylene glycol-based hydrogel that includes a multi-arm polyethylene glycol cross-linking unit covalently bound to at least four multi-arm polyethylene glycol nanocarrier units, wherein each nanocarrier unit includes an agent coupled to the nanocarrier unit and each agent is selected from pH-lowering agents, bioadhesion agents, microbicidal-spermicidal agents, and agents that inhibit free and cell-associated HIV binding, provided that each nanocarrier unit comprises a different agent.
    Type: Application
    Filed: November 18, 2016
    Publication date: May 18, 2017
    Inventors: Patrick J. Sinko, Michael L. Chikindas, Stanley Stein, Yashveer Singh, Sujata Sundara Rajan, Dayuan Gao, Katia Noll
  • Patent number: 9517201
    Abstract: Novel classes of multi-arm polyalkylene oxide-based materials including PEG nanocarriers, nanogel particles, and aggregated nanogel particles are disclosed. These classes of compositions may be associated with therapeutic agents and targeting moieties, or visibility enhancing agents, and may have a modified surface structure. In some embodiments the PEG-based materials can be made to provide relatively high drug loads with improved solubility and targeted delivery.
    Type: Grant
    Filed: April 6, 2009
    Date of Patent: December 13, 2016
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Stanley Stein, Hilliard Kutscher, Manjeet Deshmukh, Anupa Menjoge, Yashveer Singh, Simi Gunaseelan
  • Patent number: 9457099
    Abstract: The instant invention relates to polyethylene glycol-based dendrons, otherwise known as PEGtide dendrons, compositions thereof and methods of use.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: October 4, 2016
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Jieming Gao, Yashveer Singh, Xiaoping Zhang, Matthew S. Palombo, Stanley Stein
  • Patent number: 9421272
    Abstract: This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable difunctional moiety, as well as methods of using this nanocarrier.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: August 23, 2016
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Stanley Stein, Simi Gunaseelan, Shahriar Pooyan, Matthew Sean Palombo, Xiaoping Zhang
  • Publication number: 20160199534
    Abstract: Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solutions are sprayed simultaneously through a common orifice. Cross-linking via formation of thioether or disulfide bonds is initiated upon mixing, providing rapid gelation. The hydrogel components can be derivatized with RGD peptides or analogs thereof to promote retention in/on a body compartment such as the skin, surface of the eye, or a mucosa such as the vaginal mucosa. The cross-links are reversed using a reducing solution enabling easy removal of the hydrogel by dissolution. Processes for preparation of the cross-linker, RGD derivatized PEG and RGD-linked agents are also disclosed.
    Type: Application
    Filed: December 14, 2015
    Publication date: July 14, 2016
    Inventors: Patrick J. Sinko, Stanley Stein, Anupa R. Menjoge, Simi Gunaseelan, Siva Naga Sree Priya Anumolu, Raghavandra Navath
  • Patent number: 9211358
    Abstract: Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solutions are sprayed simultaneously through a common orifice. Cross-linking via formation of thioether or disulfide bonds is initiated upon mixing, providing rapid gelation. The hydrogel components can be derivatized with RGD peptides or analogs thereof to promote retention in/on a body compartment such as the skin, surface of the eye, or a mucosa such as the vaginal mucosa. The cross-links are reversed using a reducing solution enabling easy removal of the hydrogel by dissolution. Processes for preparation of the cross-linker, RGD derivatized PEG and RGD-linked agents are also disclosed.
    Type: Grant
    Filed: April 23, 2008
    Date of Patent: December 15, 2015
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Stanley Stein, Anupa R. Menjoge, Simi Gunaseelan, Siva Naga Sree Priay Anumolu, Raghavandra Navath
  • Publication number: 20150283077
    Abstract: Formulations and methods for their preparation including a hydrogel including a crosslinked matrix comprising a polymer, and a one or more liposomes containing a therapeutic agent.
    Type: Application
    Filed: March 12, 2015
    Publication date: October 8, 2015
    Inventors: Patrick J. Sinko, Stanley Stein, Anita Lalloo
  • Publication number: 20150087591
    Abstract: The present invention provides a safe, reliable, and economical process for preparing an improved dialysis fluid formulation effective for extracorporeal treatment, through a blood filtration process, of a Beta-Amyloid associated pathological condition in a subject, said process comprises preparing a composition comprising KLVFF peptide, or a variant thereof, as the capturing and binding agent, and a carrier therefor, and mixing said composition with a dialysate solution. The process utilizes a compact, inexpensive, and simple standard dialysis machine that extracorporeally removes Beta-Amyloids without allowing escape of the Beta-Amyloids back into a subject's body, without having to intricately evaluate the performance and characteristics of a dialysis membrane, and without putting the health condition of the subject at risk.
    Type: Application
    Filed: January 30, 2013
    Publication date: March 26, 2015
    Applicant: Amylex Pharmaceuticals, Inc.
    Inventors: Chinnaswamy Kasinathan, Rogelio B. Santos, JR., Stanley Stein
  • Publication number: 20140010862
    Abstract: A multifunctional polyethylene glycol-based hydrogel that includes a multi-arm polyethylene glycol cross-linking unit covalently bound to at least four multi-arm polyethylene glycol nanocarrier units, wherein each nanocarrier unit includes an agent coupled to the nanocarrier unit and each agent is selected from pH-lowering agents, bioadhesion agents, microbicidal-spermicidal agents, and agents that inhibit free and cell-associated HIV binding, provided that each nanocarrier unit comprises a different agent.
    Type: Application
    Filed: November 15, 2011
    Publication date: January 9, 2014
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Patrick J. Sinko, Michael L. Chikindas, Stanley Stein, Yashveer Singh, Sujata S. Rajan, Dayuan Gao, Katia Noll
  • Publication number: 20130072447
    Abstract: The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.
    Type: Application
    Filed: May 14, 2012
    Publication date: March 21, 2013
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Srinivasan Ramanathan, Stanley Stein, Michael Leibowitz, Patrick J. Sinko, Tamara Minko, Gregory C. Williams, Goubao Zhang, Xiaoping Zhang, Shahrair Pooyan, Seong Hee Park, Bo Qiu, Pankaj Paranjpe
  • Publication number: 20120183578
    Abstract: The instant invention relates to polyethylene glycol-based dendrons, otherwise known as PEGtide dendrons, compositions thereof and methods of use.
    Type: Application
    Filed: November 14, 2011
    Publication date: July 19, 2012
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Jieming Gao, Yashveer Singh, Xiaoping Zhang, Matthew S. Palombo, Stanley Stein
  • Publication number: 20120093723
    Abstract: This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable difunctional moiety, as well as methods of using this nanocarrier.
    Type: Application
    Filed: March 16, 2010
    Publication date: April 19, 2012
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Patrick J. Sinko, Stanley Stein, Simi Gunaseelan, Shahrair Pooyan, Matthew S. Palombo, Xiaoping Zhang
  • Patent number: 8124051
    Abstract: The present invention relates to compositions and methods for producing a complex drug delivery system which specifically targets cancer cells, has an increase in cellular uptake, is cytotoxic, and suppresses antiapoptotic cellular defenses.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: February 28, 2012
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Tamara Minko, Patrick J. Sinko, Stanley Stein
  • Publication number: 20110135732
    Abstract: The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic agent. The matrix may comprise one or more phases in addition to an aqueous phase, such as a solid and/or oil phase. The matrix of the invention has at least one controlled release in-vivo kinetic profile, and may have additional profiles for the same agent. The matrix may also comprise more than one therapeutic agent, and each additional therapeutic agent may have one or more controlled release in-vivo kinetic profile.
    Type: Application
    Filed: November 22, 2010
    Publication date: June 9, 2011
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Stanley Stein, Bo Qiu, Patrick J. Sinko
  • Publication number: 20110117024
    Abstract: Novel classes of multi-arm polyalkylene oxide-based materials including PEG nanocarriers, nanogel particles, and aggregated nanogel particles are disclosed. These classes of compositions may be associated with therapeutic agents and targeting moieties, or visibility enhancing agents, and may have a modified surface structure. In some embodiments the PEG-based materials can be made to provide relatively high drug loads with improved solubility and targeted delivery.
    Type: Application
    Filed: April 6, 2009
    Publication date: May 19, 2011
    Applicant: RUTGERS THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Stanley Stein, Hilliard Kutscher, Manjeet Deshmukh, Anupa Menjoge, Yashveer Singh, Simi Gunaseelan
  • Publication number: 20110087004
    Abstract: The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.
    Type: Application
    Filed: June 18, 2010
    Publication date: April 14, 2011
    Inventors: Srinivasan Ramanathan, Stanley Stein, Michael Leibowitz, Patrick J. Sinko, Tamara Minko, Gregory C. Williams, Goubao Zhang, Xiaoping Zhang, Shahrair Pooyan, Seong Hee Park, Bo Qiu, Pankaj Paranjpe
  • Publication number: 20110033503
    Abstract: Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solutions are sprayed simultaneously through a common orifice. Cross-linking via formation of thioether or disulfide bonds is initiated upon mixing, providing rapid gelation. The hydrogel components can be derivatized with RGD peptides or analogs thereof to promote retention in/on a body compartment such as the skin, surface of the eye, or a mucosa such as the vaginal mucosa. The cross-links are reversed using a reducing solution enabling easy removal of the hydrogel by dissolution. Processes for preparation of the cross-linker, RGD derivatized PEG and RGD-linked agents are also disclosed.
    Type: Application
    Filed: April 23, 2008
    Publication date: February 10, 2011
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Stanley Stein, Anupa R. Menjoge, Simi Gunaseelan, Siva Naga Sree priay Anumolu, Raghavandra Navath
  • Patent number: 7846893
    Abstract: Monodisperse macromolecular conjugate compositions of a peptidic carrier irreversibly or reversibly conjugated with one or more effectors and one or more therapeutic agents, wherein at least one effector or therapeutic agent is attached to a pendant reactive group on said peptidic carrier via a water-soluble polymer. Monodispersity is obtained through the use of orthogonal and separate conjugation reactions.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: December 7, 2010
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Patrick J. Sinko, Stanley Stein, Simi Gunaseelan, Shahriar Pooyan, Li Wan, Xiaoping Zhang
  • Patent number: 7740882
    Abstract: The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: June 22, 2010
    Inventors: Srinivasan Ramanathan, Stanley Stein, Michael Leibowitz, Patrick J. Sinko, Tamara Minko, Gregory C. Williams, Goubao Zhang, Xiaoping Zhang, Shahrair Pooyan, Seong Hee Park, Bo Qiu, Pankaj Paranjpe