Patents by Inventor Stefan Andersson-Engels
Stefan Andersson-Engels has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10143380Abstract: A method and system for luminescence molecular imaging or tomography of a region of interest in a scattering medium is disclosed. The system comprises a non-linear luminescent marker material arranged in the scattering medium, one or more light sources positioned by at least one light source position for exciting said luminescent marker by excitation light emitted by said one or more light sources into an excitation volume, a detector at a luminescent light detection position detecting luminescence from said luminescent marker due to said excitation light, wherein said excitation light comprises pulsed excitation light.Type: GrantFiled: July 1, 2013Date of Patent: December 4, 2018Assignee: Lumito ABInventors: Stefan Andersson Engels, Can Xu, Haichun Liu, Pontus Svenmarker
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Patent number: 9950187Abstract: A system and method for interactive therapy and diagnosis of a human or animal comprising at least one first radiation source for emission of a diagnostic radiation, at least one second radiation source for emission of a therapeutic radiation, and at least one radiation conductor adapted to conduct radiation to a tumor site at or in said human or animal. A non-mechanical operation mode selector directs the therapeutic radiation and/or the diagnostic radiation to the tumor site through the radiation conductors. The operation mode selector means is preferably a non-mechanical optical switch and/or an optical combiner. The system may be used for interactive interstitial photodynamic tumor therapy.Type: GrantFiled: September 30, 2016Date of Patent: April 24, 2018Assignee: SPECTRACURE ABInventors: Marcelo Soto Thompson, Stefan Andersson Engels, Sune Svanberg
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Publication number: 20170021189Abstract: A system and method for interactive therapy and diagnosis of a human or animal comprising at least one first radiation source for emission of a diagnostic radiation, at least one second radiation source for emission of a therapeutic radiation, and at least one radiation conductor adapted to conduct radiation to a tumor site at or in said human or animal. A non-mechanical operation mode selector directs the therapeutic radiation and/or the diagnostic radiation to the tumor site through the radiation conductors. The operation mode selector means is preferably a non-mechanical optical switch and/or an optical combiner. The system may be used for interactive interstitial photodynamic tumor therapy.Type: ApplicationFiled: September 30, 2016Publication date: January 26, 2017Inventors: Marcelo Soto Thompson, Stefan Andersson Engels, Sune Svanberg
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Patent number: 9486640Abstract: A system and method for interactive therapy and diagnosis of a human or animal comprising at least one first radiation source for emission of a diagnostic radiation, at least one second radiation source for emission of a therapeutic radiation, and at least one radiation conductor adapted to conduct radiation to a tumor site at or in said human or animal. A non-mechanical operation mode selector directs the therapeutic radiation and/or the diagnostic radiation to the tumor site through the radiation conductors. The operation mode selector means is preferably a non-mechanical optical switch and/or an optical combiner. The system may be used for interactive interstitial photodynamic tumor therapy.Type: GrantFiled: May 14, 2004Date of Patent: November 8, 2016Assignee: SpectraCure ABInventors: Marcelo Soto Thompson, Stefan Andersson Engels, Sune Svanberg
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Publication number: 20150196201Abstract: A method and system for luminescence molecular imaging or tomography of a region of interest in a scattering medium is disclosed. The system comprises a non-linear luminescent marker material arranged in the scattering medium, one or more light sources positioned by at least one light source position for exciting said luminescent marker by excitation light emitted by said one or more light sources into an excitation volume, a detector at a luminescent light detection position detecting luminescence from said luminescent marker due to said excitation light, wherein said excitation light comprises pulsed excitation light.Type: ApplicationFiled: July 1, 2013Publication date: July 16, 2015Inventors: Stefan Andersson Engels, Can Xu, Haichun Liu, Pontus Svenmarker
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Patent number: 9012869Abstract: A method and system for luminescence molecular imaging or tomography of a region of interest in a scattering medium is disclosed. The system comprises a non-linear luminescent marker material arranged in the scattering medium. Contrast and resolution of the imaging or tomography is thus improved. The non-linear marker is for instance configured to upconvert incoming light of an illumination wavelength. The non-linear power dependence of the marker enables further improvement of the imaging by using images taken with two or more excitation beams simultaneously.Type: GrantFiled: May 5, 2010Date of Patent: April 21, 2015Assignee: Lumito ABInventors: Stefan Andersson-Engels, Can Xu, Haichun Liu, Johan Axelsson, Niclas Svensson, Pontus Svenmarker
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Patent number: 8986358Abstract: A method and system for controlling and adjusting light in interstitial photodynamic light therapy (IPDT) in a subject is disclosed. More particularly, a method for controlling the light in interstitial tumor photodynamic light therapy is described using a calculation method for determination of status of tissue during the PDT treatment. The status is used in a feedback loop to control the continued PDT treatment. Methods are disclosed that constitute pre-treatment and realtime dosimetry modules for IPDT on the whole prostate glandular tissue. The method includes reconstruction of the target geometry, optimization of source fiber positions within this geometry, monitoring of the light attenuation during the treatment procedure and updating individual fiber irradiation times to take into account any variation in tissue light transmission.Type: GrantFiled: August 15, 2007Date of Patent: March 24, 2015Assignee: Spectracure ABInventors: Sune Svanberg, Johan Axelsson, Johannes Swartling, Ann Johansson, Stefan Andersson-Engels
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Patent number: 8582841Abstract: A system for providing interstitial photodynamic and/or photothermal therapy on a region of tissue in a body, comprising at least one light source adapted to deliver a therapeutic light to the region of tissue, such that the light source is interstitially inserted into the tissue for interaction with a photosensitizer agent and/or for providing a controlled thermal environment of the tissue; and a unit for determining an optimized number of the light sources and individual position of each of the light sources in the region of tissue as well as individual control parameters for each of the light sources.Type: GrantFiled: July 14, 2010Date of Patent: November 12, 2013Assignee: SpectraCure ABInventors: Johannes Swartling, Sune Svanberg, Johan Axelsson, Stefan Andersson-Engels, Jarl Ebbe Johansson
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Publication number: 20120104281Abstract: A method and system for luminescence molecular imaging or tomography of a region of interest in a scattering medium is disclosed. The system comprises a non-linear luminescent marker material arranged in the scattering medium. Contrast and resolution of the imaging or tomography is thus improved. The non-linear marker is for instance configured to upconvert incoming light of an illumination wavelength. The non-linear power dependence of the marker enables further improvement of the imaging by using images taken with two or more excitation beams simultaneously.Type: ApplicationFiled: May 5, 2010Publication date: May 3, 2012Applicant: Lumito ABInventors: Stefan Andersson-Engels, Can Xu, Haichun Liu, Johan Axelssen, Niclas Svensson, Pontus Svenmarker
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Publication number: 20120032377Abstract: Method, apparatus and stamp for aligning a first surface (11) of a first object (10) with a second surface (22) of a second object (20), facing said first surface, wherein light of a predetermined wavelength is introduced into one (10) of said objects and caused to propagate by internal reflection therein. The first and second surfaces carry correlating structures (13,25) which, when arranged at close distance from each other, couple light from said one object to the other of said objects by near-field tunneling, to a degree dependent on the overlap of said structures. A light detector (26) is devised to detect a signal which is dependent on the amount of light coupled between said objects, for producing an alignment control signal. The invention is suitable for use in nanoimprint lithography.Type: ApplicationFiled: October 25, 2004Publication date: February 9, 2012Inventors: Lars Montelius, Marc Beck, Patrick Carlberg, Claes-Göran Wahlström, Anders Persson, Stefan Andersson-Engels
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Patent number: 7988715Abstract: A system and method for interactive interstitial photo-dynamic tumour therapy and/or photothermal tumour therapy of a human or animal, said system comprising at least one radiation distributor, which is arranged for distribution of optical radiation from at least one radiation source to a reaction site, or from the reaction site to at least one radiation sensor. The radiation distributor comprises at least one translatory displacement element being translatory movable relatively to another element. First ends of first radiation conductors are fixed to the first translatory displacement element and first ends of second radiation conductors are fixed to the other element, wherein the first and the second radiation conductors are connectable to each other in different constellations through translatory movement of the translatory displacement element and the other element relative each other in order to obtain different operation modes of said system.Type: GrantFiled: May 14, 2004Date of Patent: August 2, 2011Assignee: SpectraCure ABInventors: Thomas Johansson, Charlotta Eker, Jörgen Malmborg, Lasse Wesseltoft Mogensen, Sune Svanberg, Marcelo Soto Thompson, Stefan Andersson Engels
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Publication number: 20110034971Abstract: A method and system for controlling and adjusting light in interstitial photodynamic light therapy (IPDT) in a subject is disclosed. More particularly, a method for controlling the light in interstitial tumor photodynamic light therapy is described using calculation method for determination of status of tissue during the PDT treatment. The status is used in a feedback loop to control the continued PDT treatment. Methods are disclosed that constitute pre-treatment and realtime dosimetry modules for IPDT on the whole prostate glandular tissue. The method includes reconstruction of the target geometry, optimization of source fiber positions within this geometry, monitoring of the light attenuation during the treatment procedure and updating individual fiber irradiation times to take into account any variation in tissue light transmission.Type: ApplicationFiled: August 15, 2007Publication date: February 10, 2011Applicant: Spectracure ABInventors: Sune Svanberg, Johan Axelsson, Johannes Swartling, Ann Johansson, Stefan Andersson-Engels
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Publication number: 20100185099Abstract: A system and method for therapy and diagnosis of a human or animal. At least one coupling element for coupling of radiation couples radiation from at least a first radiation source to a tumor site and/or from said second radiation source to said site and/or from said site to a detector. The coupling elements are combinations of at least one translatory distributor, at least one rotary distributor, and at least one operation mode selector means for directing either said therapeutic radiation or said diagnostic radiation to said site through said at least one first radiation conductor. The system may be used for interactive interstitial photodynamic tumor therapy. The system and method according to the invention combines the advantages of purely mechanical and purely non-mechanical solutions in a new and synergetic way.Type: ApplicationFiled: January 18, 2010Publication date: July 22, 2010Inventors: Ann Johansson, Stefan Andersson Engels, Thomas Johansson, Sara Pålsson, Marcelo Soto Thompson, Katarina Svanberg, Sune Svanberg
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Patent number: 7745789Abstract: The present invention relates to apparatuses for use in performing a quantitative analysis of a turbid pharmaceutical sample, e.g. a tablet, a capsule or a similar sample forming a pharmaceutical dose. A pharmaceutical, turbid sample (24, 57, 67) is irradiated with an excitation beam (20, 53, 64) of radiation, e.g. near infrared radiation. The intensity of emitted radiation (30) from the sample (24, 57, 67) is detected as function of both the wavelength of the emitted radiation and the photon propagation time through said sample (24, 57, 67). Optionally, the intensity of the emitted radiation (30) from the sample (24, 57, 67) is also detected in a spatially resolved manner.Type: GrantFiled: July 14, 2006Date of Patent: June 29, 2010Assignee: Astrazeneca ABInventors: Christoffer Abrahamsson, Stefan Andersson-Engels, Staffan Folestad, Jonas Johansson, Sune Svanberg
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Patent number: 7276700Abstract: The present invention relates to a method for analysing the amount of free gas within a pharmaceutical sample. According to the invention the method comprises the following steps: providing a sample before an irradiating source; irradiating the sample with at least one beam of electromagnetic radiation; detecting radiation emitted through the sample and generating signals corresponding to the amount of free gas in the sample, and correlating the generated signals to at least one solid state parameter of the sample.Type: GrantFiled: March 12, 2003Date of Patent: October 2, 2007Assignee: AstraZeneca ABInventors: Christoffer Abrahamson, Stefan Andersson-Engels, Staffan Folestad, Jonas Johansson, Mikael Sjöholm, Gabriel Somesfalean, Sune Svanberg
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Publication number: 20060243911Abstract: The present invention relates to apparatuses for use in performing a quantitative analysis of a turbid pharmaceutical sample, e.g. a tablet, a capsule or a similar sample forming a pharmaceutical dose. A pharmaceutical, turbid sample (24,57, 67) is irradiated with an excitation beam (20, 53, 64) of radiation, e.g. near infrared radiation. The intensity of emitted radiation (30) from the sample (24, 57, 67) is detected as function of both the wavelength of the emitted radiation and the photon propagation time through said sample (24, 57, 67). Optionally, the intensity of the emitted radiation (30) from the sample (24, 57, 67) is also detected in a spatially resolved manner.Type: ApplicationFiled: July 14, 2006Publication date: November 2, 2006Inventors: Christoffer Abrahamsson, Stefan Andersson-Engels, Staffan Folestad, Jonas Johansson, Sune Svanberg
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Patent number: 7105823Abstract: The present invention relates to apparatuses for use in performing a quantitative analysis of a turbid pharmaceutical sample, e.g. a tablet, a capsule or a similar sample forming a pharmaceutical dose. A pharmaceutical, turbid sample (24, 57, 67) is irradiated with an excitation beam (20, 53, 64) of radiation, e.g. near infrared radiation. The intensity of emitted radiation (30) from the sample (24, 57, 67) is detected as function of both the wavelength of the emitted radiation and the photon propagation time through said sample (24, 57, 67). Optionally, the intensity of the emitted radiation (30) from the sample (24, 57, 67) is also detected in a spatially resolved manner.Type: GrantFiled: March 18, 2002Date of Patent: September 12, 2006Assignee: AstraZeneca ABInventors: Christoffer Abrahamsson, Stefan Andersson-Engels, Staffan Folestad, Jonas Johansson, Sune Svanberg
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Patent number: 7037325Abstract: A distributor for a system for interactive interstitial photodynamic and photothermal tumor therapy and tumor diagnosis, comprises a plurality of primary radiation conductors arranged for conducting radiation to and from the tumor site, a plurality of secondary radiation conductors, two flat discs abutting against each other, wherein a first of said discs is fixed and the second of said discs is turnable relatively to the other disc, and each disc has holes arranged on a circular line. The proximal ends of the primary radiation conductors are fixed in the holes of the fixed disc and distal ends of the secondary radiation conductors are fixed in the holes of the turnable disc, whereby the primary and the secondary radiation conductors by rotation of the turnable disc are connectable to each other in different constellations.Type: GrantFiled: November 11, 2002Date of Patent: May 2, 2006Assignee: SpectraCure ABInventors: Sune Svanberg, Stefan Andersson-Engels, Katarina Svanberg
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Publication number: 20050173637Abstract: The present invention relates to a method for analysing the amount of free gas within a pharmaceutical sample. According to the invention the method comprises the following steps: providing a sample before an irradiating source; irradiating the sample with at least one beam of electromagnetic radiation; detecting radiation emitted through the sample and generating signals corresponding to the amount of free gas in the sample, and correlating the generated signals to at least one solid state parameter of the sample.Type: ApplicationFiled: March 12, 2003Publication date: August 11, 2005Inventors: Christoffer Abrahamson, Stefan Andersson-Engels, Staffan Folestad, Jonas Johansson, Mikael Sjoholm, Gabriel Somesfalean, Sune Svanberg
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Publication number: 20040260366Abstract: A distributor for a system for interactive interstitial photodynamic tumour therapy and/or photothermal tumour therapy and/or tumour diagnosis, comprises a plurality of first radiation conductors arranged for conducting radiation to and from the tumour site, a plurality of second radiation conductors, two flat discs abutting against each other, wherein a first of said discs is fixed and the second of said discs is turnable relatively to the other disc, and each disc has holes arranged on a circular line. The first ends of the first radiation conductors are fixed in the holes of the fixed disc and first ends of the second radiation conductors are fixed in the holes of the turnable disc, whereby the first and the second radiation conductors by rotation of the turnable disc are connectable to each other in different constellations.Type: ApplicationFiled: August 16, 2004Publication date: December 23, 2004Inventors: Sune Svanberg, Stefan Andersson-Engels, Katarina Svanberg