Patents by Inventor Stefan Antonius Henricus de Vries

Stefan Antonius Henricus de Vries has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Notochordal cell matrix as a bioactive lubricant for the osteoarthritic joint
    Patent number: 11779609
    Abstract: A notochordal cell matrix solution as a bioactive lubricant in the treatment of Osteoarthritis, more specifically for use as a bioactive lubricant in viscosupplementation. The notochordal cell matrix solution is capable of reducing the pain in osteoarthritic joints.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: October 10, 2023
    Assignee: TECHNISCHE UNIVERSITEIT EINDHOVEN
    Inventors: Keita Ito, Stefan Antonius Henricus De Vries
  • Notochordal cell matrix as a stimulant for intervertebral disc regeneration
    Patent number: 11607473
    Abstract: A solubilized notochordal cell matrix powder dissolved in a carrier solvent or formed as a gel is provided. The notochordal cell matrix powder originates from lyophilized and treated porcine nucleus pulposus tissue containing notochordal cells. The powder contains less than 20% of porcine nucleid acids, and the powder contains a substantially unchanged amount of porcine protein content compared to the originating porcine nucleus pulposus tissue. The solubilized notochordal cell matrix powder is capable of stimulating native or stem cells to proliferate and produce a significant increase inglycosaminoglycansand type-II collagen matrix. Embodiments of the invention can be used for the disc regenerative treatment of discogenic back and neck pain in an orthopaedic and/or pharmaceutical setting/approach.
    Type: Grant
    Filed: January 10, 2017
    Date of Patent: March 21, 2023
    Assignee: TECHNISCHE UNIVERSITEIT EINDHOVEN
    Inventors: Keita Ito, Stefan Antonius Henricus de Vries
  • NOTOCHORDAL CELL MATRIX AS A BIOACTIVE LUBRICANT FOR THE OSTEOARTHRITIC JOINT
    Publication number: 20210113626
    Abstract: A notochordal cell matrix solution as a bioactive lubricant in the treatment of Osteoarthritis, more specifically for use as a bioactive lubricant in viscosupplementation. The notochordal cell matrix solution is capable of reducing the pain in osteoarthritic joints.
    Type: Application
    Filed: January 30, 2019
    Publication date: April 22, 2021
    Applicant: TECHNISCHE UNIVERSITEIT EINDHOVEN
    Inventors: Keita ITO, Stefan Antonius Henricus DE VRIES
  • Notochordal cell matrix as a bioactive lubricant for the osteoarthritic joint
    Publication number: 20190160109
    Abstract: A solubilized notochordal cell matrix powder dissolved in a carrier solvent or formed as a gel is provided. The notochordal cell matrix powder originates from lyophilized and treated porcine nucleus pulposus tissue containing notochordal cells. The powder contains less than 20% of porcine nucleid acids, and the powder contains a substantially unchanged amount of porcine protein content compared to the originating porcine nucleus pulposus tissue. The solubilized notochordal cell matrix powder is capable of stimulating native or stem cells to proliferate and produce a significant increase in glycosaminoglycans and type-II collagen matrix. Embodiments of the invention can be used as a lubricant with regenerative potential for application in the osteoarthritic joint.
    Type: Application
    Filed: January 30, 2019
    Publication date: May 30, 2019
    Inventors: Keita Ito, Stefan Antonius Henricus de Vries