Abstract: A process is disclosed for communicating digital data between a powered device and a charging device via a universal serial bus (USB). The process includes conducting a handshaking period between the powered device and the charging device via the USB. The powered device initiates a mode of normal operation of the charging device after an end of the handshaking period. The charging device communicates digital data (e.g., available power levels) between the powered device and the charging device during a time period that starts with the end of the handshaking period and ends with a beginning of the mode of normal operation.

Abstract: A method for controlling a power converter switch to regulate power delivered to an output of a power converter includes operating the power converter switch in first, second, and third duty cycle control modes in response to a feedback signal. The first duty cycle control mode includes modulating a peak switch current of the power converter switch in response to the feedback signal, and switching the power converter switch at a substantially fixed first switching frequency value. The second duty cycle control mode includes modulating the switching frequency in response to the feedback signal, and maintaining the peak switch current substantially at a peak switch current threshold value. The third duty cycle control mode includes modulating the peak switch current of the power converter switch in response to the feedback signal, and switching the power converter switch at a substantially fixed second switching frequency value.

Abstract: A controller for use in a power converter includes an oscillator that generates a first signal that determines a duration of a switching cycle period of a switch included in the power converter. The controller also includes a logic circuit that generates a second signal to control switching of the switch in response to a feedback signal and in response to the first signal. The logic circuit generates the second signal to control a peak switch current of the switch during each switching cycle period according to either a first mode of operation or a second mode of operation. The peak switch current of the switch is varied in the first mode of operation in response to the feedback signal indicating that an output load is greater than a threshold and the peak switch current of the switch is kept at a constant value in the second mode of operation in response to the feedback signal indicating that the output load is less than the threshold.

Abstract: BET-protein-inhibitory, in particular BRD4-inhibitory bicyclo- and spirocyclically substituted 2,3-benzodiazepines of the general formula (I), pharmaceutical compositions comprising the compounds according to the invention, and the prophylactic and therapeutic use thereof for hyperproliferative disorders, especially for tumour disorders, are described. Furthermore, the use of BET protein inhibitors in benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, in neurodegenerative disorders, in inflammatory disorders, in atherosclerotic disorders and in male fertility control is described.

Abstract: A controller for use in a power converter includes a drive circuit coupled to control switching of a power switch of the power converter to regulate the output of the power converter. A limit sense circuit is coupled to output a limit sense signal in response to a condition of the power converter. The drive circuit is coupled to operate in a first operation mode if there is a no limit condition. The first operation mode includes regulating the output of the power converter with a regulated output voltage and a first maximum output current. The drive circuit is coupled to operate in a second operation mode if there is a limit condition. The second operation mode regulating the output of the power converter with the regulated output voltage and a second maximum output current wherein the second maximum output current is less than the first maximum output current.

Abstract: A power converter includes an energy transfer element and a power switch coupled the energy transfer element and an input of the power converter. A control circuit is coupled to generate a switching signal to control switching of the power switch in response to a feedback signal representative of an output of the power converter. A programming interface circuit is coupled to the control circuit and a coupling switcher coupled to the programming interface circuit. A programming terminal is selectively coupled to the programming interface circuit through the coupling switcher. A programming circuit coupled to the programming terminal is coupled to the programming interface circuit through the coupling switcher during a startup programming condition and during a fault condition of the power converter, and is decoupled from the programming interface circuit by the coupling switcher during a normal operating condition of the power converter.

Abstract: Spiroindoline derivatives, processes for their preparation and pharmaceutical compositions thereof, their use for the treatment of diseases, and their use for the manufacture of medicaments for the treatment of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selected from the group of endometriosis, uterine leiomyoma (fibroids), polycystic ovarian disease, menorrhagia, dysmenorrhea, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception, infertility and assisted reproductive therapy such as in vitro fertilization. The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.

Abstract: A fault detection circuit for use with a power converter includes an initiate fault check circuit coupled to generate an enable signal in response to a first sense signal coupled to be received from an output socket. A threshold detection circuit is coupled to generate a threshold detection output signal in response to a second sense signal coupled to be received from the power converter and a second reference signal. A logic circuit is coupled to generate a fault signal that is coupled to be received by the power converter in response to the threshold detection output signal and the enable signal.

Abstract: A controller includes a PWM circuit and a timing circuit. The PWM circuit controls a switch in response to a clock signal. A switching period of the clock signal is based on a charging and discharging time of a capacitor included in the timing circuit. Both first and second current sinks discharge the capacitor while the timing circuit is in a normal discharging mode that is when an on time of the switch is less than a threshold time. The second current sink is prevented from discharging the capacitor such that the capacitor is discharged with the first current sink and not the second current sink while the timing circuit is in an alternative discharging mode that is when the on time of the switch exceeds the threshold time. The discharging of the capacitor in the alternative discharging mode increases the switching period of the clock signal.

Abstract: An example controller for a power converter to provide power to a load through a distribution network includes a control circuit and a cable drop compensator. The control circuit outputs a drive signal to control switching of a switch to regulate an output of the power converter in response to a feedback signal. The cable drop compensator is coupled to adjust the feedback signal in response to a conduction time of an output diode of the power converter to compensate for a distribution voltage dropped across the distribution network.

Abstract: What is described are BET protein-inhibitory, in particular BRD4-inhibitory 2,3-benzodiazepines of the general formula (I) in which R1a, R1b, R1c, R2, R3, R4, R5, A and X have the meanings given in the description, intermediates for preparing the compounds according to the invention, pharmaceutical compositions comprising the compounds according to the invention and their prophylactic and therapeutic use for hyperproliferative disorders, in particular for tumour disorders. Also described is the use of BET protein inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for the control of male fertility.

Abstract: Spiroindoline derivatives, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selected from the group of endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reproductive therapy such as in vitro fertilization). The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.

Abstract: A process is disclosed for communicating digital data between a powered device and a charging device via a universal serial bus (USB). The process includes conducting a handshaking period between the powered device and the charging device via the USB. The powered device initiates a mode of normal operation of the charging device after an end of the handshaking period. The charging device communicates digital data (e.g., available power levels) between the powered device and the charging device during a time period that starts with the end of the handshaking period and ends with a beginning of the mode of normal operation.

Abstract: A controller for use in a power converter includes an oscillator that generates a first signal that determines a duration of a switching cycle period of a switch included in the power converter. The controller also includes a logic circuit that generates a second signal to control switching of the switch in response to a feedback signal and in response to the first signal. The logic circuit generates the second signal to control a peak switch current of the switch during each switching cycle period according to either a first mode of operation or a second mode of operation. The peak switch current of the switch is varied in the first mode of operation in response to the feedback signal indicating that an output load is greater than a threshold and the peak switch current of the switch is kept at a constant value in the second mode of operation in response to the feedback signal indicating that the output load is less than the threshold.

Abstract: An example controller for use in a power converter includes an oscillator that is to be coupled to a switch of the power converter to determine a switching cycle period of the switch. The controller also includes means for controlling a duty cycle of the switch to regulate an output of the power converter and for maintaining a substantially constant rate of change of the duty cycle with respect to changes in a magnitude of a feedback signal as the controller transitions between duty cycle control modes such that a control loop gain of the power converter is substantially constant during the transition.

Abstract: A power converter includes an energy transfer element and a power switch coupled the energy transfer element and an input of the power converter. A control circuit is coupled to generate a switching signal to control switching of the power switch in response to a feedback signal representative of an output of the power converter. A programming interface circuit is coupled to the control circuit and a coupling switcher coupled to the programming interface circuit. A programming terminal is selectively coupled to the programming interface circuit through the coupling switcher. A programming circuit coupled to the programming terminal is coupled to the programming interface circuit through the coupling switcher during a startup programming condition and during a fault condition of the power converter, and is decoupled from the programming interface circuit by the coupling switcher during a normal operating condition of the power converter.

Abstract: A controller includes a PWM circuit and a timing circuit. The PWM circuit controls a switch in response to a clock signal. A switching period of the clock signal is based on a charging and discharging time of a capacitor included in the timing circuit. Both first and second current sinks discharge the capacitor while the timing circuit is in a normal discharging mode that is when an on time of the switch is less than a threshold time. The second current sink is prevented from discharging the capacitor such that the capacitor is discharged with the first current sink and not the second current sink while the timing circuit is in an alternative discharging mode that is when the on time of the switch exceeds the threshold time. The discharging of the capacitor in the alternative discharging mode increases the switching period of the clock signal.

Abstract: A controller includes a current sense circuit and a voltage regulation circuit. The current sense circuit generates a first signal that indicates whether a current through a sense terminal exceeds a first threshold current level, which indicates a fault condition of a power converter. The voltage regulation circuit regulates the sense terminal to a first voltage level when the current through the terminal is less than the first threshold current level and regulates the sense terminal to a second voltage level when the current exceeds the first threshold current level. The current sense circuit generates a second signal that indicates whether the current through the sense terminal exceeds a second threshold current level while the sense terminal is regulated to the second voltage level. The response circuit generates an output signal that determines a response of the controller to the fault condition based on the second signal.

Abstract: A timing circuit of a controller generates a clock signal having a switching period for use by a pulse width modulation (PWM) circuit to control a switch of a power supply. The switching period of the clock signal is based on a charging time plus a discharging time of a capacitor included in the timing circuit. A first current source charges the capacitor while the timing circuit is in a normal charging mode. A second current source charges the capacitor while the timing circuit is in an alternative charging mode that is when the on time of the switch exceeds a threshold time. The current provided by the second current source is less than the current provided by the first current source such that the switching period of the clock signal is increased in response to the timing circuit entering the alternative charging mode.

Abstract: A power converter controller is disclosed. An example controller includes a control circuit coupled to receive a feedback signal representative of an output of the power converter. The control circuit coupled to control a switching of a power switch of the power converter in response to the feedback signal to control a transfer of energy from an input of the power converter to the output of the power converter. An internal programming interface circuit is coupled to the control circuit. A coupling switcher is coupled to the internal programming interface circuit. An external programming terminal is selectively coupled to the internal programming interface circuit through the coupling switcher. An external programming circuit coupled to the external programming terminal is coupled to the internal programming interface circuit through the coupling switcher during a startup programming condition and during a fault condition of the power converter.