Abstract: The present invention provides methods for the non-covalent surface display of proteins of interest (POI), in particular for Fc-domain containing proteins such as antibodies. The inventive method may be used to screen and select proteins of interest of a desired phenotype. The present invention further discloses polynucleotides and proteins and methods of producing the same, which may be used in carrying out the inventive method.

Abstract: The present disclosure relates to power plants. Teachings thereof may be embodied in methods for operating a combined gas-and-steam power plant and/or combined gas-and-steam power plants. For example, some embodiments may include a method for operating a combined gas-and-steam power plant comprising: generating steam with waste gas from a gas turbine; driving a generator for providing electrical current via a turbine device; and using at least part of the heat in the steam to affect an endothermic chemical reaction.

Abstract: Polymers comprising at least one unit of formula (1) wherein n is 0 or 1, m and p are independently from each other 0, 1, 2, 3, 4, 5 or 6, provided that the sum of n, m and p is at least 2, and n and p are not 0 at the same time, Ar1 and Ar2 are independently from each other C6-14-arylene or C6-14-aryl, which may be substituted with 1 to 4 substituents independently selected from the group consisting of C1-30-alkyl, C2-30-alkenyl, C2-30-alkynyl, C5-8-cycloalkyl, C6-14-aryl and 5 to 14 membered heteroaryl, and X1, X2 and X3 are independently from each other and at each occurrence O or S, compositions comprising these polymers, and electronic devices comprising a layer formed from the compositions. Preferably, the electronic device is an organic field effect transistor and the layer is the dielectric layer.

Abstract: An interior aircraft light unit includes at least one light source, in operation emitting light with a source side light intensity distribution, the source side light intensity distribution having a first intensity region and a second intensity region, with the first intensity region having a higher light intensity than the second intensity region, and a semi-transparent layer, disposed between the at least one light source and an outside of the interior aircraft light unit, for transforming the source side light intensity distribution into an adjusted light intensity distribution, wherein the semi-transparent layer has a transparency distribution having a lower degree of transparency in the first intensity region than in the second intensity region, such that the adjusted light intensity distribution is closer to an even light intensity distribution than the source side light intensity distribution.

Abstract: The present invention provides a method for generating bispecific shark variable antibody domains (vNAR domains) and uses thereof. The present invention further provides fusion proteins comprising the inventive bispecific vNAR domains as well as polynucleotide libraries for use in the generation of the inventive bi-specific vNARs. Furthermore, the invention provides pharmaceutical compositions comprising the inventive bispecific vNARs or fusion proteins comprising bi-specific vNAR domains for use in the treatment of pathological conditions in an individual. The invention also provides kits of parts comprising the bispecific vNAR domains or fusion proteins.

Abstract: A method for making a flow conducting unit cool down more slowly where the flow conducting unit has a holding unit and is penetrated by a heat transfer medium, the temperature of the heat transfer medium is reduced such that a wall of the flow conducting unit cools down, and the holding unit dissipates thermal energy such that the wall cools down more slowly.

Abstract: The invention provides for a domain-exchanged antibody comprising a light chain (LC) composed of VL-CH3, and a heavy chain (HC) comprising VH-CH3-CH2-CH3, wherein the VL-CH3 of the LC is dimerising with the VH-CH3 of the HC thereby forming a domain-exchanged LC/HC dimer comprising a CH3LC/CH3HC domain pair, and means and method for producing the same.

Abstract: The present invention provides compounds of formula a process for their preparation, a solution comprising these compounds, a process for the preparation of a device using the solution, devices obtainable by the process and the use of the bis-azide-type compounds as cross-linkers.

Abstract: The present invention relates to the use of a mono-azide compound for cross-linking polymer strands, wherein said mono-azide compound has a structure of the formula (I): (I), wherein Q1 and Q2 are each independently from another a halogen and wherein R1, R2 and R3 are each independently from another any not comprising an azido moiety. Further, the present invention relates to a method for cross-linking polymer stands and to a cross-linked polymer composition obtainable from said method and an electronic device comprising such composition.

Abstract: Polymers comprising at least one unit of formula (1) wherein n is 0 or 1, m and p are independently from each other 0, 1, 2, 3, 4, 5 or 6, provided that the sum of n, m and p is at least 2, and n and p are not 0 at the same time, Ar1 and Ar2 are independently from each other C6-14-arylene or C6-14-aryl, which may be substituted with 1 to 4 substituents independently selected from the group consisting of C1-30-alkyl, C2-30-alkenyl, C2-30-alkynyl, C5-8-cycloalkyl, C6-14-aryl and 5 to 14 membered heteroaryl, and X1, X2 and X3 are independently from each other and at each occurrence O or S, compositions comprising these polymers, and electronic devices comprising a layer formed from the compositions. Preferably, the electronic device is an organic field effect transistor and the layer is the dielectric layer.

Abstract: A generally applicable method for the selective covalent attachment of a reporter molecule to a replicating entity that allows one to obtain specific binders from a single round of library screening is disclosed. For example, selective biotinylation of phage particles and yeast cells displaying a binder to any given target can be achieved via application of a coupled enzyme reaction that includes a peroxidase, an oxidase and a catalase.

Abstract: The invention relates to anti-TNFa antibodies which are engineered to exhibit a pH-sensitive antigen binding. The invention is preferably directed to anti-TNFa antibody adalimumab (Humira®) or biologically active variants and fragments thereof, wherein the original adalimumab antibody or variant or fragment thereof is engineered by modifications of amino acid sequence within the variable regions. Specifically, the invention relates to adalimumab or biologically active variants or fragments thereof, wherein the CDR domains are modified by replacing one or more amino acid residues by histidine residues.

Abstract: The present invention provides compounds of formula 1 wherein X1 and X2 are independently from each other O, S or Se, and an electronic device comprising the compounds as semiconducting material.

Abstract: Methods for impregnating a liquid material into a rope are provided whereby a liquid material is provided in a tank which defines the liquid level in the tank. An impregnation unit containing a chamber at least partially immersed in the liquid material includes a vacuum-device operatively connected to the vacuum-outlet of the chamber so as to lower the pressure in the chamber below atmospheric pressure. The rope may therefore be passed through the liquid material in the tank and then inside and outside the chamber via the rope-inlet and rope-outlet of the chamber, while maintaining the pressure inside the chamber below the atmospheric pressure to thereby force the liquid material to fill at least part of the interstices between the fibers of the rope by penetrating between the fibers.

Abstract: An overhead aircraft passenger service unit, which is configured to be placed above the passenger seats within an aircraft cabin, comprises at least one cavity for housing at least one oxygen mask and at least one removable cover, which at least partially covers an opening of the cavity. The removable cover houses and/or supports at least one functional component.

Abstract: The present invention provides compounds of formula 1 wherein X1 and X2 are independently from each other O, S or Se, and an electronic device comprising the compounds as semiconducting material.

Abstract: The present invention relates to a method for the preparation of polyquaternium-1, wherein an aprotic polar solvent is used as the reaction medium, and a solid polyquaternium-1 having a low degree of polydispersity.

Abstract: The invention relates to a copolymer exhibiting both antimicrobial and anti-adhesive properties as well as to a hydrogel. Said hydrogel is obtained from the inventive copolymer and a substrate. Another part of the invention is a process for making the hydrogel, as well as different uses of the inventive copolymer as well as of the hydrogel.