Abstract: The present invention provides methods for treating and/or managing pain. The invention further provides methods for reducing or inhibiting opioid tolerance, reducing risk of opioid addiction or dependence, restoring opioid efficacy, and enhancing the therapeutic effect of an opioid. The invention further provides compositions for use in the methods of the invention.

Abstract: The present invention provides methods for treating and/or managing pain. The invention further provides methods for reducing or inhibiting opioid tolerance, reducing risk of opioid addiction or dependence, restoring opioid efficacy, and enhancing the therapeutic effect of an opioid. The invention further provides compositions for use in the methods of the invention.

Abstract: The present invention provides methods for treating and/or managing pain. The invention further provides methods for reducing or inhibiting opioid tolerance, reducing risk of opioid addiction or dependence, restoring opioid efficacy, and enhancing the therapeutic effect of an opioid. The invention further provides compositions for use in the methods of the invention.

Abstract: The present invention provides methods of treating Restless Legs Syndrome (RLS) including administering to a subject an effective amount of a dopamine D1 receptor antagonist. Compositions and kits useful for treating RLS are also provided.

Abstract: The present invention provides methods for treating and/or managing pain. The invention further provides methods for reducing or inhibiting opioid tolerance, reducing risk of opioid addiction or dependence, restoring opioid efficacy, and enhancing the therapeutic effect of an opioid. The invention further provides compositions for use in the methods of the invention.

Abstract: The present invention provides methods of treating Restless Legs Syndrome (RLS) including administering to a subject an effective amount of a dopamine D1 receptor antagonist. Compositions and kits useful for treating RLS are also provided.

Abstract: The present invention provides methods of treating Restless Legs Syndrome (RLS) including administering to a subject an effective amount of a dopamine D1 receptor antagonist. Compositions and kits useful for treating RLS are also provided.

Abstract: The disclosure generally describes computer-implemented methods, software, and systems for managing information exchange between medical care applications and an analytical infrastructure for medical care information. The disclosure also describes implementations that manage user access to medical care applications and communications between medical care applications.

Abstract: The disclosure generally describes computer-implemented methods, software, and systems for managing information exchange between medical care applications and an analytical infrastructure for medical care information.

Abstract: An actuator and method for MEMS array actuation is disclosed. In one embodiment, the actuator having a pixel coupled to a charge integration circuit, the pixel comprising a voltage bias, a variable gap capacitor, and a switch, all in series, the charge integration circuit configured to modulate charge on the variable gap capacitor during an actuation cycle. In one embodiment, the MEMS actuator having a unit cell with parasitic capacitance and coupled to a negative feedback sampling circuit, the unit cell comprising a variable gap capacitor, a voltage bias, a modulated current source, and a voltage-to-current converter, the negative feedback sampling circuit configured to receive an output current from the unit cell, convert the output current from the unit cell to a low voltage signal, sample the low voltage signal, and provide a feedback signal to the modulated current source to compensate for the parasitic capacitance in the unit cell.

Abstract: A low noise readout apparatus and method for CMOS image sensors having a photosensitive element configured to collect charge when light strikes the photosensitive element, a reset gate adjacent the photosensitive element and configured to drain excess charge from the photosensitive element, a first electrode, a second electrode and a third electrode, in series and adjacent the photosensitive element, the first electrode actuated to transfer a signal charge from the photosensitive element to the first electrode, the second electrode actuated to transfer the signal charge from the first electrode to the second electrode, the third electrode actuated to transfer the signal charge from the second electrode to the third electrode and onto a sense node, and a readout circuit coupled to the sense node, the readout circuit measures a voltage corresponding to the signal charge transferred to the sense node.

Abstract: A pixel for a CMOS photo sensor with increased full well capacity is disclosed. The pixel having a photosensitive element, a photo gate, potential well and a readout circuit. The photosensitive element having a front side and a back side, for releasing charge when light strikes the back side of the photosensitive element. The potential well receives the released charge from the photosensitive element. The photo gate located on the front side of the photosensitive element, for transferring the released charge from the potential well to a sense node. The readout circuit coupled to the sense node, for measuring a voltage corresponding to the released charge transferred to the sense node.

Abstract: A pixel for a CMOS photo sensor with increased full well capacity is disclosed. The pixel having a photosensitive element, a photo gate, potential well and a readout circuit. The photosensitive element having a front side and a back side, for releasing charge when light strikes the back side of the photosensitive element. The potential well receives the released charge from the photosensitive element. The photo gate located on the front side of the photosensitive element, for transferring the released charge from the potential well to a sense node. The readout circuit coupled to the sense node, for measuring a voltage corresponding to the released charge transferred to the sense node.

Abstract: An actuator and method for MEMS array actuation is disclosed. In one embodiment, the actuator having a pixel coupled to a charge integration circuit, the pixel comprising a voltage bias, a variable gap capacitor, and a switch, all in series, the charge integration circuit configured to modulate charge on the variable gap capacitor during an actuation cycle. In one embodiment, the MEMS actuator having a unit cell with parasitic capacitance and coupled to a negative feedback sampling circuit, the unit cell comprising a variable gap capacitor, a voltage bias, a modulated current source, and a voltage-to-current converter, the negative feedback sampling circuit configured to receive an output current from the unit cell, convert the output current from the unit cell to a low voltage signal, sample the low voltage signal, and provide a feedback signal to the modulated current source to compensate for the parasitic capacitance in the unit cell.

Abstract: A low noise readout apparatus and method for CMOS image sensors having a photosensitive element configured to collect charge when light strikes the photosensitive element, a reset gate adjacent the photosensitive element and configured to drain excess charge from the photosensitive element, a first electrode, a second electrode and a third electrode, in series and adjacent the photosensitive element, the first electrode actuated to transfer a signal charge from the photosensitive element to the first electrode, the second electrode actuated to transfer the signal charge from the first electrode to the second electrode, the third electrode actuated to transfer the signal charge from the second electrode to the third electrode and onto a sense node, and a readout circuit coupled to the sense node, the readout circuit measures a voltage corresponding to the signal charge transferred to the sense node.

Abstract: A low noise readout apparatus and method for CMOS image sensors having a complementary metal oxide semiconductor with a plurality of pixels, each pixel having a charge-generating unit configured to release a charge, a potential well for receiving the released charge from the charge-generating unit, a first gate, a second gate and a floating gate, in series and adjacent the potential well, the first gate transfers the charge from the potential well to the second gate, the second gate transfers the charge to the floating gate to generate a first corresponding readout voltage, the first gate, the second gate and the floating gate transfer the charge back and forth, at least once, to generate at least a second corresponding readout voltage, and a readout circuit coupled to the floating gate, the readout circuit measures a voltage corresponding to the charge transferred to the floating gate.

Abstract: A fast off-line image processing method for radiographic images is disclosed wherein an image is decomposed into detail image and multiple resolution levels and a residual image, detail images are modified up to a preset resolution level and a processed image is reconstructed by means of the modified detail images and the residual image. Interactive processing is performed with different parameter settings.