Patents by Inventor Stefan Golz
Stefan Golz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240150271Abstract: The present invention is directed to methods for the preparation of (CnF2n+1)O-substituted arenes and heteroarenes and the direct perfluoralkoxy lation of arenes and heteroarenes with a (CnF2n+1)O-group, respectively. characterized in that a peroxide reagent according to the general formula (I): (CnF2n+1)2 (I) is fragmented in the presence of an electron transferring catalyst under (CnF2n+1)O-radical formation, and said (CnF2n+1)O-radical then substitutes a C—H bond of an arene or heteroarene C—H bond with a (CnF2n+1)O-group, wherein in the above formulae, n is an integer in the range from 1 to 4.Type: ApplicationFiled: February 21, 2022Publication date: May 9, 2024Applicant: Solvay SAInventors: Sebastian Hasenstab-Riedel, Matthew Hopkinson, Stefan Dix, Paul Golz, Jonas Rachid Schmid, Holger Pernice, Sebastian Gutmann
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Publication number: 20230304561Abstract: A switchable hydraulic bearing for mounting of a motor-vehicle assembly comprises a support bearing and a mount connected by a support spring, and a working chamber and an equalization chamber fillable with damping liquid that are spatially separated by a separating wall and connected by a damping channel in the separating wall. The separating wall may comprise a nozzle cage with two adjacent nozzle discs provided with an axial spacing. A diaphragm of rubber-elastic material may be provided in a gap between the nozzle discs. The diaphragm may be switchable by a switching device comprising an elastic lever disc axially adjacent to the second nozzle disc. An electromagnet may connect to the lever disc and can adjust the lever disc between a first position, permitting axial play of the diaphragm in the gap, and a second position, acting on the second nozzle disc and clamping the diaphragm between nozzle discs.Type: ApplicationFiled: April 14, 2021Publication date: September 28, 2023Inventors: Wolfgang Beckmann, Roland Holz, Stefan Gölz, Bernhard Röhrig
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Publication number: 20230151442Abstract: A lysis buffer comprising one non-ionic surfactant is provided which can be used as a one-step reagent of the preparation, storage, amplification, and/or detection of nucleic acids. Various embodiments of the lysis buffer of the invention comprise other substances that are compatible or useful in lysing cells, storing nucleic acids, amplifying nucleic acids, purifying nucleic acids, detecting nucleic acids, and/or other procedures for analysis of nucleic acids. Methods and kits based on the lysis buffer are also provided, including those for rapid lysis of cells and direct use of the resulting cell lysates in RT-PCR.Type: ApplicationFiled: April 1, 2021Publication date: May 18, 2023Applicant: Bayer AktiengesellschaftInventors: Stefan GOLZ, Holger SUMMER, Silke AIGNER, Heidrun ELLINGER-ZIEGELBAUER, Kirsten LEINEWEBER, Thomas MÜLLER
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Patent number: 11549566Abstract: A hydraulically damping mount for mounting a motor vehicle unit on a motor vehicle body includes a support and a support mount which are interconnected by a support spring made of an elastomeric material. In embodiments, a support spring limits a working chamber which is separated from a compensating chamber by a separating device, wherein the working chamber and the compensating chamber may be filled with a fluid and may be connected to one another via a damping channel included in the separating device, wherein the separating device may include two nozzle discs between which a first membrane and a second membrane are arranged, and wherein one of the membranes has at least one through-hole.Type: GrantFiled: December 21, 2018Date of Patent: January 10, 2023Assignee: Vibracoustic SEInventors: Roland Holz, Stefan Gölz, Robert Jambor, Tina Heilmann
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Publication number: 20210033166Abstract: A hydraulically damping mount for mounting a motor vehicle unit on a motor vehicle body includes a support and a support mount which are interconnected by a support spring made of an elastomeric material. In embodiments, a support spring limits a working chamber which is separated from a compensating chamber by a separating device, wherein the working chamber and the compensating chamber may be filled with a fluid and may be connected to one another via a damping channel included in the separating device, wherein the separating device may include two nozzle discs between which a first membrane and a second membrane are arranged, and wherein one of the membranes has at least one through-hole.Type: ApplicationFiled: December 21, 2018Publication date: February 4, 2021Inventors: Roland Holz, Stefan Gölz, Robert Jambor, Tina Heilmann
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Patent number: 10130633Abstract: The present invention relates to substituted N-(phenyl-heteroaryl)-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-phenyl-heteroaryl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease such as cancer, wherein i.a.: LA represents an optionally substituted methylene or ethylene group; LB represents —N(H)—C(?O)— or —C(?O)—N(H)—; R1 represents an optionally substituted 5- to 8-membered heterocycloalkyl, 4- to 10-membered heterocycloalkenyl, aryl, heteroaryl or —N(R7)(Ci-C6-alkyl) group; R2 represents an optionally substituted 5- or 6-membered heteroaryl group; R3 represents an optionally substituted phenyl group.Type: GrantFiled: March 17, 2014Date of Patent: November 20, 2018Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Kai Thede, William Scott, Eckhard Bender, Stefan Golz, Andrea Hägebarth, Philip Lienau, Florian Puehler, Daniel Basting, Dirk Schneider, Manfred Möwes, Anja Richter, Ludwig Zorn, Ningshu Liu, Ursula Mönning, Franziska Siegel
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Patent number: 9943522Abstract: The present invention relates to the use of cathepsin K and/or cathepsin S inhibitors in a method for the treatment and/or prophylaxis of pulmonary hypertension and/or heart failure.Type: GrantFiled: May 11, 2012Date of Patent: April 17, 2018Assignee: BAYER INTELLECTUAL PROPERTY GMBHInventors: Stefan Golz, Martina Delbeck, Heinrich Meier, Andreas Geerts, Thomas Mondritzki, Hubert Trübel
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Publication number: 20180044306Abstract: The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: February 16, 2016Publication date: February 15, 2018Applicant: Bayer Pharma AktiengesellschaftInventors: Kai THEDE, Eckhard BENDER, William J. SCOTT, Anja GIESE, Ludwig ZORN, Ningshu LIU, Ursula MÖNNING, Franziska SIEGEL, Stefan GOLZ, Andrea HÄGEBARTH, Philip LIENAU, Florian PÜHLER, Daniel BASTING, Dirk SCHNEIDER, Manfred MÖWES, Jens GEISLER
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Publication number: 20180042931Abstract: The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) wherein LA represents *CH2** or *?**; wherein indicates the point of attachment to the carbonyl group, and ** indicates the point of attachment to R1; LB represents *N(H)—C(?O)** or *C(?O)—N(H)**; wherein * indicates the point of attachment to R2, and ** indicates the point of attachment to the phenyl group; R1 represents a group selected from: (AA); wherein * indicates the point of attachment to LA, R2 represents: (BB) wherein * indicates the point of attachment to R3, and ** indicates the point of attachment to LB R3 represents a group selected from: (CC); wherein * indicates the point of attachment to R2; R4 and R5 represent a hydrogen atom; and R6 represents a halogen atom or group selected from: —CH3, —O—CH3, —O—CHF2, —O—CF3, and —O-cyclopropyl; to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturingType: ApplicationFiled: February 16, 2016Publication date: February 15, 2018Applicant: Bayer Pharma AktiengesellschaftInventors: Kai THEDE, Eckhard BENDER, William J. SCOTT, Anja GIESE, Ludwig ZORN, Ningshu LIU, Ursula MÖNNING, Franziska SIEGEL, Stefan GOLZ, Andrea HÄGEBARTH, Philip LIENAU, Florian PÜHLER, Daniel BASTING, Dirk SCHNEIDER, Manfred MÖWES
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Patent number: 9884063Abstract: The present invention relates to amido-substituted azole compounds of general formula (I), in which X1, X2, R1, R2, R4, R5, R7 and R8 are as defined in the claims which are inhibitors of TNKS1 and/or TNKS2, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.Type: GrantFiled: April 1, 2015Date of Patent: February 6, 2018Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Knut Eis, Jens Ackerstaff, Sarah Wagner, Daniel Basting, Stefan Golz, Eckhard Bender, Volkhart Min-Jian Li, Philip Lienau, Ningshu Liu, Franziska Siegel, Marcus Bauser, Detlev Sülzle, Simon Holton, Michaela Bairlein, Philipp Buchgraber, József Bálint
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Publication number: 20180028507Abstract: The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients, in which: R1 represents a group selected from: C1-C3-alkoxy-C2-C3-alkyl-, (A), (B), (C), (D), (E), (F), (G) or (H); wherein * indicates the point of attachment to the rest of the molecule; R2 represents a group selected from: (I), (J) or (K); wherein * indicates the point of attachment to the rest of the molecule.Type: ApplicationFiled: February 16, 2016Publication date: February 1, 2018Applicant: Bayer Pharma AktiengesellschaftInventors: Kai THEDE, Eckhard BENDER, William J. SCOTT, Anja GIESE, Ludwig ZORN, Ningshu LIU, Ursula MÖNNING, Franziska SIEGEL, Stefan GOLZ, Andrea HÄGEBARTH, Philip LIENAU, Florian PÜHLER, Daniel BASTING, Dirk SCHNEIDER, Manfred MÖWES
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Publication number: 20170368171Abstract: The invention provides human AdipoR2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of AdipoR2 as well as pharmaceutical compositions comprising such compounds.Type: ApplicationFiled: January 17, 2017Publication date: December 28, 2017Applicant: Siemens Healthcare Diagnostics Inc.Inventors: STEFAN GOLZ, ULF BRUGGEMEIER, ANDREAS GEERTS
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Patent number: 9745557Abstract: The invention relates to the nucleotide and amino acid sequences, and to the activity and use, of the luciferases LuAL, Lu164, Lu16, Lu39, Lu45, Lu52 and Lu22.Type: GrantFiled: May 15, 2015Date of Patent: August 29, 2017Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Stefan Golz, Bernd Kalthof, Svetlana Markova, Ludmila Frank, Eugene Vysotski
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Publication number: 20170114070Abstract: The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: March 18, 2015Publication date: April 27, 2017Inventors: Kai THEDE, Eckhard BENDER, William SCOTT, Anja GIESE, Ludwig ZORN, Ningshu LIU, Ursula MÖNNING, Franziska SIEGEL, Stefan GOLZ, Andrea HÄGEBARTH, Philip LIENAU, Florian PUEHLER, Daniel BASTING, Dirk SCHNEIDER, Manfred MÖWES, Jens GEISLER
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Publication number: 20170107212Abstract: The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: March 18, 2015Publication date: April 20, 2017Inventors: Kai THEDE, Eckhard BENDER, William SCOTT, Anja GIESE, Ludwig ZORN, Ningshu LIU, Ursula MÖNNING, Franziska SIEGEL, Stefan GOLZ, Andrea HÄGEBARTH, Philip LIENAU, Florian PUEHLER, Daniel BASTING, Dirk SCHNEIDER, Manfred MÖWES, Jens GEISLER
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Publication number: 20160263122Abstract: The present invention relates to substituted N-(phenyl-heteroaryl)-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-phenyl-heteroaryl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease such as cancer, wherein i.a.: LA represents an optionally substituted methylene or ethylene group; LB represents —N(H)—C(?0)- or —C(?0)—N(H)—; R1 represents an optionally substituted 5- to 8-membered heterocycloalkyl, 4- to 10-membered heterocycloalkenyl, aryl, heteroaryl or —N(R7)(Ci-C6-alkyl) group; R2 represents an optionally substituted 5- or 6-membered heteroaryl group; R3 represents an optionally substituted phenyl group.Type: ApplicationFiled: March 17, 2014Publication date: September 15, 2016Inventors: Kai THEDE, William SCOTT, Eckhard BENDER, Stefan GOLZ, Andrea HÄGEBARTH, Philip LIENAU, Florian PUEHLER, Daniel BASTING, Dirk SCHNEIDER, Manfred MOWES, Anja RICHTER, Ludwig ZORN, Ningshu LIU, Ursula MONNING, Franziska SIEGEL
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Publication number: 20160096874Abstract: The present invention is in the field of molecular biology, more particularly, the present invention relates to drug screening, assay development and identification and use of modulators for G-protein coupled receptor/ligand pair MRGX2/CXCL14 within drug discovery.Type: ApplicationFiled: June 16, 2014Publication date: April 7, 2016Inventors: Stefan GOLZ, Sina MICUS
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Publication number: 20160052898Abstract: The present invention relates to substituted N-biphenyl-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-biphenyl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disorder, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: March 20, 2014Publication date: February 25, 2016Inventors: Kai THEDE, William Johnston SCOTT, Eckhard BENDER, Stefan GOLZ, Andrea HÄGEBARTH, Philip LIENAU, Florian PUEHLER, Daniel BASTING, Dirk SCHNEIDER, Manfred MÖWES, Anja RICHTER, Ludwig ZORN, Ningshu LIU, Ursula MÖNNING, Franziska SIEGEL
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Publication number: 20150247131Abstract: The invention relates to the nucleotide and amino acid sequences, and to the activity and use, of the luciferases LuAL, Lu164, Lu16, Lu39, Lu45, Lu52 and Lu22.Type: ApplicationFiled: May 15, 2015Publication date: September 3, 2015Inventors: Stefan GOLZ, Bernd KALTHOF, Svetlana MARKOVA, Ludmila FRANK, Eugene VYSOTSKI
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Patent number: 9040691Abstract: This invention relates to novel 5-[(hydroxymethyl)aryl]-substituted pyrrolo[2,1-f][1,2,4]triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.Type: GrantFiled: June 26, 2012Date of Patent: May 26, 2015Assignee: BAYER INTELLECTUAL PROPERTY GMBHInventors: Jürgen Klar, Verena Vöhringer, Joachim Telser, Mario Lobell, Frank Süβmeier, Volkhart Min-Jian Li, Michael Böttger, Stefan Golz, Dieter Lang, Karl-Heinz Schlemmer, Thomas Schlange, Andreas Schall, Wenlang Fu