Abstract: The present invention provides methods for utilizing blended compositions of acetonitrile and toluene as organic wash solvents in the production of a synthetic oligonucleotide, the blended compositions producing higher synthetic oligonucleotide yields than a pure acetonitrile wash solvent. The method also provides a process for removing one or more impurities from the acetonitrile and toluene containing wash solvent received as a waste stream from the oligonucleotide synthesis process. The process includes adding at least one of an iodine reactive compound, a sulfur reactive compound and/or an acidic reactive compound to the waste stream, and fractionating the waste stream. The fractionation produces an overhead fraction and a bottom fraction where the overhead fraction includes the acetonitrile and the toluene, and the bottom fraction includes the one or more impurities.

Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: A method and device are provided for marking electrical devices which can be arranged in a row on a support rail, with the aid of a laser head, wherein the support rail is pivotable about its longitudinal axis and the laser head is guided such that it can be moved at least along the longitudinal axis of the support rail. A number of marking instructions, each including a marking content and a position and an orientation of the surface to which the marking content is to be applied are specified. An image of at least a section of the support rail and of at least one electrical device are created from an image capture device and at least one of the positions at which one of the marking contents is to be applied is corrected based on an evaluation of the image. The marking instructions are grouped into marking levels in such a way that all marking instructions of one marking level can be applied by the laser head without a movement of the laser head or the support rail.

Abstract: The present invention generally relates to antibodies that bind to GPRC5D, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: The invention relates to a lighting strip system (1) comprising a support rail system (10) and luminaires (200) and further components (300) connected thereto, wherein electrical lines (120) are arranged inside the support rail (100), and wherein the electrical lines (120) comprise both a main power supply line (130) and other lines (180). The support rail system furthermore comprises a data transceiver (20) for modulating further data signals D onto at least one of the other lines (180). A method for data communication within the lighting strip system (1) is also specified.

Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: A housing for a luminaire or an operating device for the luminaire, wherein the housing is configured to accommodate at least one electronic component and/or a light source, and comprising a conductive housing component (2). The housing includes at least one line (1, 1?, 1?, 1??, 1??) for transmitting electric high frequency signals or for transmitting and/or receiving radio waves. The transmission line is formed by arranging a dielectric layer (4, 4a, 4b, 9) and a conductor (3, 3 . . . 3c, 7) on the housing component (2) such that the conductive housing component (2) serves as a reference plane, and the conductive housing component (2) and the conductor (3, 3 . . . 3c, 7) sandwich the dielectric layer (4, 4a, 4b, 9).

Abstract: The present invention generally relates to antibodies that bind to GPRC5D, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: A method and device are provided for marking electrical devices which can be arranged in a row on a support rail, with the aid of a laser head, wherein the support rail is pivotable about its longitudinal axis and the laser head is guided such that it can be moved at least along the longitudinal axis of the support rail. A number of marking instructions, each including a marking content and a position and an orientation of the surface to which the marking content is to be applied are specified. An image of at least a section of the support rail and of at least one electrical device are created from an image capture device and at least one of the positions at which one of the marking contents is to be applied is corrected based on an evaluation of the image. The marking instructions are grouped into marking levels in such a way that all marking instructions of one marking level can be applied by the laser head without a movement of the laser head or the support rail.

Abstract: The present invention generally relates to antibodies that bind to GPRC5D, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: The present invention generally relates to antibodies that bind to GPRC5D, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: An apparatus for marking electric devices which can be arranged next to one another and mounted on a support rail includes a receptacle for the support rail and a laser head for applying a marking to the electric devices. The receptacle is mounted for pivotal movement about its longitudinal axis and the laser head is guided for movement in at least one longitudinal direction parallel to the longitudinal axis of the receptacle.

Abstract: Optoelectronic radiation device, in particular for generating and emitting health-promoting and regenerative radiation, comprising: at least one or more optoelectronic radiation sources configured to generate infrared radiation, and at least one optoelectronic radiation source for generating white light, wherein the infrared radiation is in an infrared spectral range between 600 nm and 900 nm.

Abstract: Herein is reported a method for the production of a polypeptide that is biologically active as n-mer comprising a nucleic acid encoding a fusion polypeptide according to the following formula (Bn-CSo-Is-CSp-FC-CSq-It-CSr-Bm)u, wherein B denotes a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region, FC denotes a heavy chain Fc-region polypeptide, CS denotes a cleavage site, and I denotes an intervening amino acid sequence, wherein FC does not substantially bind to an Fc-receptor, recovering the fusion polypeptide from the cell or the cultivation medium, optionally cleaving the fusion polypeptide with a protease, and thereby producing a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region.

Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: The invention relates to a lighting assembly which comprises a lighting device for emitting blue light, and a controller for operating the lighting device, the controller being designed to adjust the melanopic effect factor of the blue light.

Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: In at least one embodiment of the method for controlling an illumination of an object, the object is illuminated by a first radiation source during the method. A second radiation source is provided, the latter being configured to illuminate the object in addition to the first radiation source. The method comprises a step A), in which a first measurement signal is captured, wherein a change in the first measurement signal is representative for a change in a first radiation property of radiation striking the object. In a step B), the second radiation source is controlled, on the basis of a detected change in the first measurement signal, in such a way that the second radiation source illuminates the object and the change in the first radiation property of the radiation striking the object is counteracted.

Abstract: A deposition apparatus for coating a flexible substrate is described. The deposition apparatus comprises a first spool chamber housing a storage spool for providing the flexible substrate, a deposition chamber arranged downstream from the first spool chamber, and a second spool chamber arranged downstream from the deposition chamber and housing a wind-up spool for winding the flexible substrate thereon after deposition. The deposition chamber comprises a coating drum for guiding the flexible substrate past a plurality of deposition units including at least one deposition unit having a graphite target. The coating drum is connected to a device for applying an electrical potential to the coating drum.

Abstract: The present invention generally relates to antibodies that bind to GPRC5D, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.