Abstract: The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns: a) a first part, G1, comprising from about 5 to about 70% w/w of the total dose of acarbose, b) a second part, G2A, comprising from about 30 to about 95% w/w of the total dose of acarbose, c) a third part, G2B, comprising from about 10 to about 90% w/w of the total dose of orlistat, and d) a fourth part, G3, comprising from about 10 to about 80% w/w of the total dose of orlistat, and the total concentration of acarbose and orlistat, respectively, in the composition is 100% w/w.

Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for CD69 and provides a CD69-binding polypeptide comprising the sequence EX2X3X4AX6X7EIX10 X11LPNLX16X17X18QK X21AFKX25X26LKD. The present disclosure also relates to the use of such a CD69-binding polypeptide as a therapeutic, prognostic and/or diagnostic agent.

Abstract: A network node (120) and method therein for performing multi-channel access procedures in a License-Assisted Access, LAA, cell in a wireless communication network are disclosed. The network node selects one carrier as a master carrier and starts a Listen Before Talk, LBT, channel sensing for all carriers at a same or different point in time. The network node further stores LBT channel sensing results for all carriers for at least the last two slot durations of a subframe and checks if the LBT channel sensing on the master carrier is successful based on its LBT channel sensing result. When the LBT channel sensing on the master carrier is successful, the network node checks the LBT channel sensing results for all other carriers, and transmits on the master carrier and the carriers where the LBT channel sensing is successful at the subframe boundary or earlier than the subframe boundary.

Abstract: A network node (110) and method therein for evaluating a channel in a License Assisted Access, LAA, cell in a wireless communication network (100) are disclosed. The network node starts a Listen Before Talk, LBT, procedure for data transmission when a Discovery Reference Signal, DRS, is to be transmitted; and start an LBT procedure for DRS transmission in parallel with the LBT procedure for data transmission when a time of the LBT procedure for data transmission reaches a predefined value or the LBT procedure for data transmission fails.

Abstract: A rotatable tool for producing a circular groove through metal cutting in a metal work piece and a method of forming the circular groove with the rotatable tool is disclosed. The rotatable tool includes a front end and a second end. The front end includes a first radially outer cutting edge and a second radially inner cutting edge, where the first radially outer cutting edge is located at a larger radial distance from the tool center axis than any other cutting edge of the rotatable tool, and where the second radially inner cutting edge is located at a smaller radial distance from the tool center axis than any other cutting edge of the rotatable tool.

Abstract: A network node (110) and method therein for evaluating a channel in a License Assisted Access, LAA, cell in a wireless communication network (100) are disclosed. The network node starts a Listen Before Talk, LBT, procedure for data transmission when a Discovery Reference Signal, DRS, is to be transmitted; and start an LBT procedure for DRS transmission in parallel with the LBT procedure for data transmission when a time of the LBT procedure for data transmission reaches a predefined value or the LBT procedure for data transmission fails.

Abstract: A network node (120) and method therein for performing multi-channel access procedures in a License-Assisted Access, LAA, cell in a wireless communication network are disclosed. The network node selects one carrier as a master carrier and starts a Listen Before Talk, LBT, channel sensing for all carriers at a same or different point in time. The network node further stores LBT channel sensing results for all carriers for at least the last two slot durations of a subframe and checks if the LBT channel sensing on the master carrier is successful based on its LBT channel sensing result. When the LBT channel sensing on the master carrier is successful, the network node checks the LBT channel sensing results for all other carriers, and transmits on the master carrier and the carriers where the LBT channel sensing is successful at the subframe boundary or earlier than the subframe boundary.

Abstract: A rotatable tool for producing a circular groove through metal cutting in a metal work piece and a method of forming the circular groove with the rotatable tool is disclosed. The rotatable tool includes a front end and a second end. The front end includes a first radially outer cutting edge and a second radially inner cutting edge, where the first radially outer cutting edge is located at a larger radial distance from the tool center axis than any other cutting edge of the rotatable tool, and where the second radially inner cutting edge is located at a smaller radial distance from the tool center axis than any other cutting edge of the rotatable tool.

Abstract: The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns: a) a first part, G1, comprising from about 5 to about 70% w/w of the total dose of acarbose, b) a second part, G2A, comprising from about 30 to about 95% w/w of the total dose of acarbose, c) a third part, G2B, comprising from about 10 to about 90% w/w of the total dose of orlistat, and d) a fourth part, G3, comprising from about 10 to about 80% w/w of the total dose of orlistat, and the total concentration of acarbose and orlistat, respectively, in the composition is 100% w/w.

Abstract: The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns: a) a first part, G1, comprising from about 5 to about 70% w/w of the total dose of acarbose, b) a second part, G2A, comprising from about 30 to about 95% w/w of the total dose of acarbose, c) a third part, G2B, comprising from about 10 to about 90% w/w of the total dose of orlistat, and d) a fourth part, G3, comprising from about 10 to about 80% w/w of the total dose of orlistat, and the total concentration of acarbose and orlistat, respectively, in the composition is 100% w/w.

Abstract: The present invention relates to a modified-release composition comprising orlistat and acarbose, comprising individually distinct parts with different release patterns: a) a first part, G1, comprising from about 5 to about 70% w/w of the total dose of acarbose, b) a second part, G2A, comprising from about 30 to about 95% w/w of the total dose of acarbose, c) a third part, G2B, comprising from about 10 to about 90% w/w of the total dose of orlistat, and d) a fourth part, G3, comprising from about 10 to about 80% w/w of the total dose of orlistat, and the total concentration of acarbose and orlistat, respectively, in the composition is 100% w/w.

Abstract: A rotatable tool for producing a circular groove through metal cutting in a metal work piece and a method of forming the circular groove with the rotatable tool is disclosed. The rotatable tool includes a front end and a second end. The front end includes a first radially outer cutting edge and a second radially inner cutting edge, where the first radially outer cutting edge is located at a larger radial distance from the tool center axis than any other cutting edge of the rotatable tool, and where the second radially inner cutting edge is located at a smaller radial distance from the tool center axis than any other cutting edge of the rotatable tool.

Abstract: A method and computer-readable media for managing software object handles in a dual threaded or multi-threaded environment are provided. In a first version a software driven computational process drives a first thread, while a garbage collector process drives a second active computational thread within a host computer. The software driven computational process generates persistent software objects that are temporarily stored in a memory of the host. Each handle may include an object identifier of the handle itself, an open/closed flag and a pointer to a unique persistent object. The open/closed flag indicates whether the persistent object associated with a handle shall remain open and accessible for processing or may be selected for closure by the garbage collector process. A plurality of handle wrappers are each associated in a one-to-one correspondence with a unique handle.

Abstract: A system, computer-readable media and method for backup one or more databases and restoring one or more databases using incremental backups are provided. Persistent collection objects are generated in the process of performing a database backup. A collection objects may order records, e.g., objects, in relation to and within pluralities of records. These pluralities of records may be referred to, or organized as, pages or containers of pages, comprising software objects. The persistent database backup collection object may include a time and date of a generation of an incremental backup database by a distinguishable and specific database archiving process (“backup event”), an event number of an incremental backup generation, one or more database identifiers, one or more container identifiers, and/or identifiers of individual records, e.g., object identifiers.

Abstract: The invention provides methods and materials related to vaccines against self polypeptides. For example, the invention provides compositions containing chimeric IgE polypeptides and adjuvants.

Abstract: A method and computer-readable media for managing software object handles in a dual threaded or multi-threaded environment are provided. In a first version a software driven computational process drives a first thread, while a garbage collector process drives a second active computational thread within a host computer. The software driven computational process generates persistent software objects that are temporarily stored in a memory of the host. Each handle may include an object identifier of the handle itself, an open/closed flag and a pointer to a unique persistent object. The open/closed flag indicates whether the persistent object associated with a handle shall remain open and accessible for processing or may be selected for closure by the garbage collector process. A plurality of handle wrappers are each associated in a one-to-one correspondence with a unique handle.

Abstract: Materials and methods for inducing an IgG anti-IgE response in a human. The methods can include administering to a human subject a polypeptide comprising a human CH3 domain of IgE located between an opossum CH2 domain of IgE and an opossum CH4 domain of IgE, wherein the polypeptide is administered at a dose from about 30 ?g to about 600 ?g.

Abstract: An arrangement for pressurizing an inflatable sleeve (2) that can be applied, for instance, to the arm of a patient for measuring the patient's blood pressure, or that can be applied to an infusion bag for forced infusion of said infusion to a patient, wherein the device further includes a sleeve-connected pressure gauge (3), a hand pump (30) which is connected to the sleeve (2) via line (54,2) and which includes an air inlet (31) that has a check valve (32), wherein the device also comprises a manually actuable air release valve (55) for controlled release of gas from the sleeve interior, wherein a box (5) is connected in the line (52,4) between the sleeve (2) and the air release valve (53); wherein the box (5) is connectable to a pressurized gas source (20) by means of a hose (8), wherein the hose (8) connects with the interior of the box (5) via a check valve (7) and a manually controllable valve (6) for the input of gas from the pressure gas source to the sleeve (2) via the box (5).

Abstract: A method of producing a tool insert which comprises a central metal portion having edge regions of superabrasive material bonded thereto and presenting cutting edges or points for the tool insert is disclosed. A body (50) having major surfaces on each of opposite sides thereof, each having spaced strips (64) of superabrasive material, typically abrasive compact such as PCBN or PCD, for example, separated by a metal region or regions, such as cemented carbide, is provided. Each superabrasive strip of one major surface is arranged in register with a superabrasive strip of the opposite major surface. Alternatively, each superabrasive strip extends from one major surface to the opposite major surface. The body is severed from one major surface to the opposite major surface along at least two sets of planes intersecting at or in the respective superabrasive strips to produce the tool insert.

Abstract: A method of producing a tool insert having superabrasive cutting points or edges is disclosed. A body (10) of a hard metal having major surfaces (12, 14) on each of opposite sides thereof, such as a cemented carbide disc, is provided. Each major surface of the body has an array of pockets (12) filled with a superabrasive material, typically an abrasive compact such as PCBN or PCD, for example. A pocket of one major surface is arranged to be in register with a pocket of the opposite major surface. The body is severed from one major surface to the opposite major surface along at least two sets of planes intersecting at or in respective superabrasive filled pockets to produce the tool insert. The severing of the body is carried out in such a manner as to expose the superabrasive material to form a cutting tip or edge in the tool insert.