Patents by Inventor Stefan Pruehs

Stefan Pruehs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 5-fluorotryptophol
    Patent number: 10323040
    Abstract: The present invention relates to a process for the preparation of 5-fluorotryptophol as well as a process for the preparation of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano-[3,4b]-indol]-4-amine using the 5-fluorotryptophol obtained by said first process. The process according to the invention provides 5-fluorotryptophol in improved yield and purity without the need for chromatographic purification of the product.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: June 18, 2019
    Assignee: GRUENENTHAL GMBH
    Inventors: Stefan Pruehs, Olaf Schaefer
  • Process for the Preparation of 5-Fluorotryptophol
    Publication number: 20160362417
    Abstract: The present invention relates to a process for the preparation of 5-fluorotryptophol as well as a process for the preparation of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano-[3,4b]-indol]-4-amine using the 5-fluorotryptophol obtained by said first process. The process according to the invention provides 5-fluorotryptophol in improved yield and purity without the need for chromatographic purification of the product.
    Type: Application
    Filed: August 26, 2016
    Publication date: December 15, 2016
    Inventors: Stefan PRUEHS, Olaf SCHAEFER
  • Solid forms of (1r,4r)-6?-fluoro-(N, N-dimethyl)-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano-[3,4,b]indol]-4-amine and sulfuric acid
    Patent number: 8912343
    Abstract: Solid forms of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4b]indol]-4-amine and sulfuric acid such as (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4b]indol]-4-amine sulfate or hemi-sulfate, particularly crystalline forms and/or amorphous forms thereof, pharmaceutical compositions and medicaments containing these solid forms, the use of these solid forms, and a process for obtaining such solid forms.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: December 16, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Michael Gruss, Stefan Kluge, Stefan Pruehs
  • Process for the preparation of (1r,4r)-6?-fluoro-(N,N-dimethyl- and N-methyl)-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano-[3,4,b]indol]-4-amine
    Patent number: 8779160
    Abstract: A process for the preparation of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4b]indol]-4-amine and (1r,4r)-6?-fluoro-N-methyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4b]-indol]-4-amine or physiologically acceptable acid addition salts thereof.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: July 15, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Stefan Pruehs, Carsten Griebel, Wolfgang Hell
  • Method for synthesizing substituted aminocyclohexanone compounds
    Patent number: 8658827
    Abstract: A method of synthesizing a substituted aminocyclohexanone compound comprising reacting a compound of formula (II) with an organolithium compound to form a compound of formula (III)
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: February 25, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Stefan Pruehs, Carsten Griebel, Marita Mueller
  • Crystalline (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
    Patent number: 8618156
    Abstract: Crystalline forms of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4,b]indol]-4-amine, pharmaceutical compositions and medicaments comprising these crystalline modifications, the use of these modifications as well as a process for the enrichment of such crystalline modifications.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: December 31, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Michael Gruss, Stefan Kluge, Stefan Pruehs
  • Crystalline (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4,b]indol]-4-amine
    Patent number: 8614245
    Abstract: Crystalline forms of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4,b]indol]-4-amine, pharmaceutical compositions and medicaments comprising these crystalline modifications, the use of these modifications as well as a process for the enrichment of such crystalline modifications.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: December 24, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Michael Gruss, Stefan Kluge, Stefan Pruehs
  • CRYSTALLINE (1R,4R)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO[3,4,B]INDOL]-4-AMINE
    Publication number: 20130012563
    Abstract: Crystalline forms of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4,b]indol]-4-amine, pharmaceutical compositions and medicaments comprising these crystalline modifications, the use of these modifications as well as a process for the enrichment of such crystalline modifications.
    Type: Application
    Filed: July 6, 2012
    Publication date: January 10, 2013
    Applicant: Gruenenthal GmbH
    Inventors: Michael Gruss, Stefan Kluge, Stefan Pruehs
  • Method for Synthesizing Substituted Aminocyclohexanone Compounds
    Publication number: 20120149914
    Abstract: A method of synthesizing a substituted aminocyclohexanone compound comprising reacting a compound of formula (II) with an organolithium compound to form a compound of formula (III)
    Type: Application
    Filed: December 7, 2011
    Publication date: June 14, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Stefan PRUEHS, Carsten GRIEBEL, Marita MUELLER
  • Progesterone receptor antagonists
    Patent number: 8053426
    Abstract: The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: November 8, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Ulrike Fuhrmann, Anja Schmidt, Arwed Cleve, Orlin Petrov, Gunnar Garke, Stefan Pruehs, Margarete Brudny-Kloeppel, Antje Rottmann, Rainer Hasselmann, Marcus Schultze-Mosgau, Carsten Moeller
  • Progesterone receptor antagonists
    Patent number: 7951790
    Abstract: The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: May 31, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Ulrike Fuhrmann, Anja Schmidt, Arwed Cleve, Orlin Petrov, Gunnar Garke, Stefan Pruehs, Margarete Brudny-Kloeppel, Antje Rottmann, Rainer Hasselmann, Marcus Schultze-Mosgau, Carsten Moeller
  • Progesterone receptor antagonists
    Patent number: 7902178
    Abstract: The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: March 8, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Ulrike Fuhrmann, Anja Schmidt, Arwed Cleve, Orlin Petrov, Gunnar Garke, Stefan Pruehs, Margarete Brudny-Kloeppel, Antje Rottmann, Rainer Hasselmann, Marcus Schultze-Mosgau, Carsten Moeller
  • Progesterone receptor antagonists
    Publication number: 20080200440
    Abstract: The present invention relates to progesterone receptor antagonists of general formula I: in which R1 can be a hydrogen atom and R2 a hydroxyl group or R1 and R2 together can be an oxo group.
    Type: Application
    Filed: November 15, 2007
    Publication date: August 21, 2008
    Inventors: Ulrike Fuhrmann, Anja Schmidt, Arwed Cleve, Orlin Petrov, Gunnar Garke, Stefan Pruehs, Margarete Brudny-Kloeppel, Antje Rottmann, Rainer Hasselmann, Marcus Schultze-Mosgau, Carsten Moeller