Abstract: The present invention relates to a method for detecting (D)-2-hydroxyglutarate or (D)-2-hydroxyadipic acid in a sample, the method comprising the steps of: a) contacting a sample with a reagent mixture, wherein said reagent mixture comprises: (i) a solvent, (ii) a dye having an oxidized state and a reduced state, wherein the reduced state can be distinguished from the oxidized state and wherein the dye is initially present in the oxidized state, (iii) an electron transfer agent, (iv) a (D)-2-hydroxyglutarate dehydrogenase enzyme, and (v) a cofactor; and b) detecting (D)-2-hydroxyglutarate or (D)-2-hydroxyadipic acid by measuring the production of the reduced state of the dye. The invention further pertains to a method for diagnosing and/or monitoring a (D)-2-hydroxy-glutarate-associated disease in a subject. Encompassed by the invention is also a method for diagnosing a mutation in an isocitrate dehydrogenase (IDH) gene or in a (D)-2-hydroxyglutarate (D2HG) dehydrogenase enzyme gene in a subject.

Abstract: The present invention relates to a method for detecting (D)-2-hydroxyglutarate or (D)-2-hydroxyadipic acid in a sample, the method comprising the steps of: a) contacting a sample with a reagent mixture, wherein said reagent mixture comprises: (i) a solvent, (ii) a dye having an oxidized state and a reduced state, wherein the reduced state can be distinguished from the oxidized state and wherein the dye is initially present in the oxidized state, (iii) an electron transfer agent, (iv) a (D)-2-hydroxyglutarate dehydrogenase enzyme, and (v) a cofactor; and b) detecting (D)-2-hydroxyglutarate or (D)-2-hydroxyadipic acid by measuring the production of the reduced state of the dye. The invention further pertains to a method for diagnosing and/or monitoring a (D)-2-hydroxy-glutarate-associated disease in a subject. Encompassed by the invention is also a method for diagnosing a mutation in an isocitrate dehydrogenase (IDH) gene or in a (D)-2-hydroxyglutarate (D2HG) dehydrogenase enzyme gene in a subject.

Abstract: What is described is a configuration for determining the position of a body along a movement direction, wherein the body is in the form of a magnetized encoder with two magnetic tracks extending, on one surface of the body, along the movement direction, at least essentially in parallel with one another, wherein, at specified intervals along the movement direction, a first of the magnetic tracks exhibits magnetized sections in which the magnetic north poles are aligned so as to be at least largely coincident in a magnetization direction that is essentially at right-angles to the surface of the body, and wherein, at intervals specified to coincide with the above-mentioned intervals along the movement coordinate, the second of the magnetic tracks exhibits magnetized sections in which the magnetic south poles are aligned so as to be at least largely coincident in the said magnetization direction, and wherein, in each case, a magnetized section of one of the magnetic tracks is located at least largely centrally in

Abstract: What is described is a configuration for determining the position of a body along a movement direction, wherein the body is in the form of a magnetized encoder with two magnetic tracks extending, on one surface of the body, along the movement direction, at least essentially in parallel with one another, wherein, at specified intervals along the movement direction, a first of the magnetic tracks exhibits magnetized sections in which the magnetic north poles are aligned so as to be at least largely coincident in a magnetization direction that is essentially at right-angles to the surface of the body, and wherein, at intervals specified to coincide with the above-mentioned intervals along the movement coordinate, the second of the magnetic tracks exhibits magnetized sections in which the magnetic south poles are aligned so as to be at least largely coincident in the said magnetization direction, and wherein, in each case, a magnetized section of one of the magnetic tracks is located at least largely centrally in

Abstract: An arrangement for detecting the angle of rotation of a rotatable element. The arrangement includes a plurality of magnetic field-sensitive sensor elements which are substantially planar and are substantially arranged in one plane, which sensor elements are connected to at least two bridge circuits each supplying a signal assigned to a function of the angle of rotation. A substantially planar coil arranged with its planar extension along the planar arrangement of the sensor elements supplies a magnetic auxiliary field to the sensor arrangement. To allow an unambiguous measurement through a large angular range, preferably up to 360°, with a compact, simple and low-cost arrangement, the sensor elements of each bridge circuit are arranged in a star-shaped configuration, the sensor elements of the different bridge circuits are interleaved in a star-shaped concentric manner, and the substantially planar coil includes a substantially spirally concentric, planar, circular winding along its planar extension.

Abstract: Arrangement for determining a position, an angle and/or a rotational speed by means of a sensor (1), which has at least one sensor full bridge with two half bridges (3, 4), and by means of an encoder (2; 11) with laterally alternating magnet poles, a sinusoidal magnetic field running through the sensor (1) in the event of a relative movement between the sensor (1) and encoder (2; 11) such that the two half bridges (3, 4) of the sensor (1) each supply a sinusoidal sensor signal (V1, V2), and a sum signal (SUM) and a difference signal (DIFF) being obtained from these signals by means of forming sums and differences, respectively, which are evaluated in order to determine a position, an angle and/or a rotational speed.

Abstract: In an arrangement for detecting the angle of rotation of a rotatable element, in which, while evaluating properties of a sensor arrangement which can be magnetically influenced, a first magnetic field generated or influenced by the rotatable element is detectable and can be used for determining the angle of rotation, the sensor arrangement comprises a plurality of magnetic field-sensitive sensor elements which are substantially planar and are substantially arranged in one plane, which sensor elements are connected to at least two bridge circuits each supplying a signal assigned to a function of the angle of rotation. The sensor arrangement is adapted to supply signals which are unambiguously assignable to a direction of the first magnetic field via a first angular range.

Abstract: A sensor arrangement comprising two sensors (1, 2) and processing unit (16) for deriving a measurement signal (M1, M2) from two sensor signals (S1, S2) which are each supplied by one sensor (1, 2). Such a sensor arrangement may comprise for example two angular-position sensors which measure the angular position of a measurement object with respect to the sensor arrangement.