Abstract: A device for foaming liquid foods in a container, particularly milk, is provided having a vapor generator for generating vapors, particularly steam, and a vapor lance to be at least partially inserted into the container, with the vapor lance being connected to the vapor generator in a fluid-guiding fashion and including at least one vapor outlet opening such that steam can be discharged from the vapor generator via the vapor lance out of the vapor outlet opening. The device further includes at least one motion element which is connected to the vapor lance and/or a holder for the container such that the vapor lance and the container are movable relative to each other via the motion element.

Abstract: This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis diagnostics and imaging.

Abstract: A container for holding and dispensing a liquid and/or dissolved active substance, for example a pharmaceutical or cosmetic active substance, has at least one dispensing organ (5) for dispensing, preferably in a portioned manner, the one active substance. Provision is also made for at least two holding chambers (9, 11) separated from one another, at least one of which contains the one active substance and at least one of which contains an at least largely active-substance-free liquid and/or a further active substance differing from the one active substance, wherein the dispensing organ is connected to the at least one chamber containing the active substance for dispensing purposes.

Abstract: The disclosure provides a HER3 binding polypeptide, comprising a HER3 binding motif, BM, which motif consists of the amino acid sequence selected from i) EX2X3X4A X6X7EIW X11LPNL X16X17X18QX20 X21AFIX25 X26LX28D, and ii) an N amino acid sequence which has at least 90% identity to the sequence defined in i), wherein the polypeptide binds to the extra-cellular domain of HER3. Also provided is a bispecific ligand having binding affinity for HER3 and for HER2, or for HER3 and for EGFR, and comprising a HER3. binding polypeptide as defined herein and a HER2 binding polypeptide or a EGFR binding polypeptide.

Abstract: This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis diagnostics and imaging.

Abstract: A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, as well as expression vector and host cell for expressing the nucleic acid, are also provided. Also provided is the use of such a polypeptide as a medicament, and as a targeting agent for directing substances conjugated thereto to cells overexpressing HER2. Methods, and kits for performing the methods, are also provided, which methods and kits rely on the binding of the polypeptide to HER2.

Abstract: A device (1, 10) and method for the production of cooled coffee are provided. The device has a brewing unit (4) for the production of coffee, a cooling assembly (11) and a coffee cooler (14) formed as a heat exchanger. The coffee cooler (14) has at least one first and one second flow path that are connected thermally but not in a fluid-conducting manner. A coolant can flow through the first flow path and the second flow path is connected in a fluid-conducting manner with a coffee outlet (5) of the brewing unit (4). The device also has a fresh-water supply (2) and a fresh-water cooler (13) formed as an additional heat exchanger.

Abstract: A device for foaming liquid foods in a container, particularly milk, is provided having a vapor generator for generating vapors, particularly steam, and a vapor lance to be at least partially inserted into the container, with the vapor lance being connected to the vapor generator in a fluid-guiding fashion and including at least one vapor outlet opening such that steam can be discharged from the vapor generator via the vapor lance out of the vapor outlet opening. The device further includes at least one motion element which is connected to the vapor lance and/or a holder for the container such that the vapor lance and the container are movable relative to each other via the motion element.

Abstract: A polypeptide is provided, which has a binding affinity for HER2 and which is related to a domain of staphylococcal protein A (SPA) in that the sequence of the polypeptide corresponds to the sequence of the SPA domain having from 1 to about 20 substitution mutations. Nucleic acid encoding the polypeptide, as well as expression vector and host cell for expressing the nucleic acid, are also provided. Also provided is the use of such a polypeptide as a medicament, and as a targeting agent for directing substances conjugated thereto to cells overexpressing HER2. Methods, and kits for performing the methods, are also provided, which methods and kits rely on the binding of the polypeptide to HER2.

Abstract: This invention relates to polypeptides which bind to EGFR family receptors and to applications of those polypeptides in medicine, veterinary medicine, diagnosis diagnostics and imaging.

Abstract: The present invention provides a method of producing an insulin C-peptide, which comprises expressing in a host cell a multimeric polypeptide comprising multiple copies of a said insulin C-peptide, and cleaving said expressed polypeptide to release single copies of the insulin C-peptide.

Abstract: The present invention relates to flexible facilities for supplying documents where the index to the documents is stored in a central archive but the documents themselves are stored in an external archiving system. The solution according to the invention is based on management of the addresses in the external archiving systems which is undertaken at the central archive. The approach adopted supports the specifying of any desired number of backup servers and, by allowing the configurable supply either of the address relation itself and/or of server address information attached to the list of search results, it provides a facility which supports the full range of document supply capabilities available when a central archive system is being used.

Abstract: The present invention provides a method of producing an insulin C-peptide, which comprises expressing in a host cell a multimeric polypeptide comprising multiple copies of the insulin C-peptide, and cleaving the expressed polypeptide to release single copies of the insulin C-peptide. Also provided are nucleic acid molecules, expression vectors and host cells, for use in such a method and the multimeric insulin C-peptide polypeptide expressed and cleaved in such a method.

Abstract: A complex of an immunogen and a support molecule, characterized in that the immunogen is coupled covalently to a support molecule, wherein the support molecule is a polypeptide fragment which is able to bind specifically to mammalian serum albumin is disclosed. The invention also relates to the use of such complexes to treat RSV infection, as well as vaccines derived from such complexes.

Abstract: The present invention relates to a process for improving the immunogenicity of an immunogen, an antigen or a hapten, when it is administered to a host, independently of the mode of administration, characterized in that the said antigen or hapten is coupled covalently to a support molecule in order to form a complex, and in that this support molecule is a polypeptide fragment which is able to bind specifically to mammalian serum albumin. The invention also relates to the use, as a medicament, of the product which can be obtained in this way.

Abstract: A method for obtaining a Staphylococcus carnosus bacterium expressing at its membrane surface a recombinant polypeptide derived from RSV protein G, said polypeptide having a sequence which is a modification of SEQ ID No. 1 and SEQ ID No. 2 (sequence encompassed between residues 130 and 230 of RSV A and RSV B protein G respectively) wherein at least one of position 44 and 57 is serine is disclosed.

Abstract: Preparation of 5-cyanovalerates (I) by the carbonylation of a 1-cyanobutene with carbon monoxide and an alkanol (II) corresponding to the ester radical at an elevated temperature and under superatmospheric pressure in the presence of a cobalt catalyst as well as in the presence of an activating solvent, in which the activating solvent used is an effective amount of a urea of the formula IIIcR.sub.2 N--CO--NR.sub.2 (IIIc)where R is, C.sub.1 -C.sub.6 -alkyl, C.sub.5 -C.sub.7 -cycloalkyl or where 2R groups together form 5-membered to 7-membered rings. The end products I serve as intermediates, chiefly for the preparation of .epsilon.-caprolactam.

Abstract: Preparation of 5-cyanovalerates (I) by the carbonylation of a 1-cyanobutene with carbon monoxide and an alkanol (II) corresponding to the ester radical at an elevated temperature and under superatmospheric pressure in the presence of a cobalt catalyst as well as in the presence of an activating solvent, in which the activating solvent used is an effective amount of a carbonic diester, a carbamate, or a urea of the general formula IIIa, IIIb, or IIIcR--O--CO--O--R (IIIa)R.sub.2 N--CO--O--R (IIIb)R.sub.2 N--CO--NR.sub.2 (IIIc)or a mixture of these compounds (R's same or different, C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.7 cycloalkyl groups or together form 5-membered to 7-membered rings).The end products I serve as intermediates, chiefly for the preparation of .epsilon.-caprolactam.

Abstract: A process for preparing isoxazole-3,4-dicarboxylic acid derivatives of the formula I ##STR1## where R.sup.1 is hydrogen, alkyl, cycloalkyl or phenyl, or a 5- to 6-membered heterocyclic radical, and the organic radicals can have substituents which are inert under the reaction conditions;R.sup.2 is hydrogen, alkyl, cycloalkyl, benzyl or C.sub.3 -C.sub.6 -alkenyl;A is NR.sup.3 R.sup.4 where R.sup.3 is hydrogen or an aliphatic or cycloaliphatic radical and R.sup.4 is an aliphatic or cycloaliphatic radical or unsubstituted or substituted phenyl, or R.sup.3 forms together with R.sup.4 a 4- to 7-membered alkylene chain which can be interrupted by oxygen, sulfur or N-methyl, or is OR.sup.5 where R.sup.5 is alkyl, cycloalkyl, benzyl or alkenyl;by deprotonation of a CH-acid compound of the formula II ##STR2## using a base and reacting with hydroximyl chlorides of the formula III ##STR3## wherein a magnesium alcoholate of the formula IVMg(OR.sup.6 ).sub.2 IVwhere R.sup.