Patents by Inventor Stefan Willmann
Stefan Willmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220193085Abstract: Methods of thromboprophylaxis using rivaroxaban is provided for children with congenital heart disease post-Fontan procedure.Type: ApplicationFiled: December 16, 2021Publication date: June 23, 2022Applicants: JANSSEN PHARMACEUTICALS, INC., BAYER PHARMA ATKIENGESELLSCHAFTInventors: CHRISTOPHER NESSEL, Stefan Willmann, Dagmar Kubitza, Roger M. Mills, Catherine Vanden Boom, Elliot Barnathan, Liza Miriam Pina
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Patent number: 10285958Abstract: The invention relates to a combination of two or more pharmaceutically active substances, of which at least one is a metabolic product (“metabolite”) of the other (“parent substance”), wherein in particular the dosages thereof are selected such that genotypically or phenotypically related variability in the conversion of the parent substance to the metabolite in particular individuals is compensated for.Type: GrantFiled: May 27, 2013Date of Patent: May 14, 2019Assignee: BAYER AKTIENGESELLSCHAFTInventors: Stefan Willmann, Thomas Eiβing, Kristin Dickschen
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Publication number: 20170326080Abstract: The invention relates to a combination of two or more pharmaceutically active substances, of which at least one is a metabolic product (“metabolite”) of the other (“parent substance”), wherein in particular the dosages thereof are selected such that genotypically or phenotypically related variability in the conversion of the parent substance to the metabolite in particular individuals is compensated for.Type: ApplicationFiled: January 31, 2017Publication date: November 16, 2017Applicant: BAYER AKTIENGESELLSCHAFTInventors: Stefan WILLMANN, Thomas ElßING, Kristin DICKSCHEN
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Publication number: 20170326081Abstract: The invention relates to a combination of two or more pharmaceutically active substances, of which at least one is a metabolic product (“metabolite”) of the other (“parent substance”), wherein in particular the dosages thereof are selected such that genotypically or phenotypically related variability in the conversion of the parent substance to the metabolite in particular individuals is compensated for.Type: ApplicationFiled: June 16, 2017Publication date: November 16, 2017Inventors: Stefan Willmann, Thomas Eissing, Kristin Dickschen
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Patent number: 9095653Abstract: The invention relates to a method for the controlled dosage of a medicament as a function of time by means of a method for the determination of a corresponding dosage profile and corresponding control of a dosage instrument.Type: GrantFiled: February 19, 2005Date of Patent: August 4, 2015Assignee: BAYER INTELLECTUAL PROPERTY GMBHInventors: Stefan Willmann, Walter Schmitt, Jörg Lippert, Ingmar Dorn
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Publication number: 20150174082Abstract: The invention relates to a combination of two or more pharmaceutically active substances, of which at least one is a metabolic product (“metabolite”) of the other (“parent substance”), wherein in particular the dosages thereof are selected such that genotypically or phenotypically related variability in the conversion of the parent substance to the metabolite in particular individuals is compensated for.Type: ApplicationFiled: May 27, 2013Publication date: June 25, 2015Applicant: BAYER TECHNOLOGY SERVICES GmbHInventors: Stefan Willmann, Thomas Eissing, Kristin Dickschen
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Patent number: 8038645Abstract: The invention relates to a device for the time-controlled intravenous administering of the anesthetic propofol by means of a method used for determining an adequate dosage profile and adequately controlling an infusion pump as a metering apparatus.Type: GrantFiled: June 3, 2006Date of Patent: October 18, 2011Assignee: Bayer Technology Services GmbHInventors: Andrea Nicole Edginton, Stefan Willmann, Walter Schmitt
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Patent number: 7765092Abstract: A computer system and a method for calculating an ADME properties of a substance on the basis of molecular properties of the substance by using a biophysical model, into which the molecular properties are entered as input quantities. The biophysical model establishes a relationship between the molecular properties and the ADME properties.Type: GrantFiled: November 25, 2002Date of Patent: July 27, 2010Assignee: Bayer Technology Services GmbHInventors: Walter Schmitt, Jörg Keldenich, Jannis Batoulis, Michael Beck, Roger-Michael Brunne, Thorsten Bürger, Thorsten Pötter, Felix Reichel, Stefan Willmann
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Publication number: 20100094202Abstract: The invention relates to a device for the time-controlled intravenous administering of the anesthetic propofol by means of a method used for determining an adequate dosage profile and adequately controlling an infusion pump as a metering apparatus.Type: ApplicationFiled: June 3, 2006Publication date: April 15, 2010Applicant: BAYER TECHNOLOGY SERVICES GMBHInventors: Andrea Nicole Edginton, Stefan Willmann, Walter Schmitt
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Publication number: 20090306944Abstract: The invention relates to a device for use in the clinical/therapeutical field for the patient-individual optimization of the dosage and/or the dosage scheme of a drug based on rational, mathematical models which take into consideration possible physiological variations that are due to the illness or other particularities of the patient and the interaction with co-drugs that are administered at times close to each other. The invention also relates to the supply of said drug dose by means of a dosage device.Type: ApplicationFiled: June 16, 2007Publication date: December 10, 2009Applicant: BAYER TECHNOLOGY SERVICES GMBHInventors: Stefan Willmann, Karsten Höhn, Andreas Edginton, Walter Schmitt
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Patent number: 7539607Abstract: Computer system for calculating a pharmacokinetic behavior of a chemical substance in insects, comprising: a physiologically based pharmacokinetic simulation model (102) of an insect for predicting concentration/time profiles of the chemical substance in compartments of the insect, the simulation model having at least one parameter which is dependent on the substance, and a prediction module (110) for predicting the at least one parameter on the basis of a physicochemical property of the substance.Type: GrantFiled: November 14, 2003Date of Patent: May 26, 2009Assignee: Bayer Technology Services GmbHInventors: Stefan Willmann, Walter Schmitt
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Publication number: 20070273867Abstract: A process and an are described, which enable the analysis of very small amounts of sample (2) by infrared spectroscopy method. The invention relates in particular to a method which includes the following steps: aspirating the liquid sample (2) into a metering apparatus (1), metering the sample (2) onto the optical element (4) of an ATR apparatus, drying the sample (6), carrying out an ATR-IR spectroscopy measurement, forecasting the concentration of the analytes to be detected using a model-based calibration procedure.Type: ApplicationFiled: June 23, 2004Publication date: November 29, 2007Inventors: Edgar Diessel, Stefan Willmann, Peter Kamphaus, Frank Lison
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Publication number: 20070253903Abstract: The invention relates to a method for dosing specific doses and timed dosage profiles of medicaments (in animals and humans) as well as agrochemicals (for the treatment of plants).Type: ApplicationFiled: May 14, 2005Publication date: November 1, 2007Applicant: BAYER TECHNOLOGY SERVICES GMBHInventors: Bernhard Knab, Jorg Lippert, Roland Loosen, Andreas Schuppert, Michael Sevestre, Juri Solodenko, Stefan Willmann
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Publication number: 20070196479Abstract: The invention relates to a method for the controlled dosage of a medicament as a function of time by means of a method for the determination of a corresponding dosage profile and corresponding control of a dosage instrument.Type: ApplicationFiled: February 19, 2005Publication date: August 23, 2007Inventors: Stefan Willmann, Walter Schmitt, Jorg Lippert, Ingmar Dorn
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Publication number: 20050137807Abstract: A method is described for selecting chemical compounds and visualizing their ADME properties using an indication-specific target profile. In one embodiment, the method comprises determining and/or selecting molecular properties of one or more compounds in a computer database. This information is used to generate one or more ADME maps describing the compounds' behaviour in a biophysical model. An indication-specific target profile of the desired ADME properties is defined and compared with the compounds' actual ADME profile or map to make an optimized selection of compounds.Type: ApplicationFiled: October 22, 2004Publication date: June 23, 2005Applicant: Bayer Technology Services GmbHInventors: Jorg Lippert, Michael Sevestre, Walter Schmitt, Stefan Willmann
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Publication number: 20050119832Abstract: The invention relates to a computer system and a method for calculating an ADME property of a substance, which comprises the following steps: a. input of molecular properties of said substance into a biophysical model, whereby said biophysical model describes a correlation between the molecular properties and the ADME property and b. output of the ADME property.Type: ApplicationFiled: November 25, 2002Publication date: June 2, 2005Inventors: Walter Schmitt, Jorg Keldenich, Jannis Batoulis, Michael Beck, Roger-Michael Brunne, Thorsten Burger, Thorsten Potter, Felix Reichel, Stefan Willmann
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Publication number: 20050075274Abstract: A method for determining the interaction of one or more chemical active compounds with organisms. The method comprises selecting at least one compound and analyzing its physiko-chemical and/or biochemical characteristics including its pharmacokinetic properties in various anatomical and physiological compartments of the organism in question. The relevant physiological compartments are characterized with respect to the compound's various pharmacokinetic properties that may vary with the mode of administering the compound. A combined system of coupled differential equations is then used to simulate a concentration-time curve of the active compound in selected compartments.Type: ApplicationFiled: September 8, 2004Publication date: April 7, 2005Applicant: Bayer Technology Services GmbHInventors: Stefan Willmann, Walter Schmitt, Franco Fois
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Publication number: 20050074803Abstract: Method for determining the dose of at least one active agent based on a genetic analysis. The method comprises analyzing specific genes for their nucleotide sequence or their expression levels of gene-specific proteins and/or RNA molecules. The gene-specific data is assigned one or more relevant physiological functions of the human or animal body, in particular those which have an influence on the metabolism, absorption, excretion or distribution of the active agent in the body. The gene-specific data and the assigned physiological functions are then integrated into a physiology-based pharmacokinetic model (PBPK model). The PBPK model integrates pharmacokinetic data relating to one or more active agents. The PBPK model may also receive and evaluate patient-specific data directly inputted and combined with data from a knowledge database comprising known values of pharmacokinetic parameters. The PBPK's integration of these data provide a calculation of the individual dose of the active agent.Type: ApplicationFiled: September 23, 2004Publication date: April 7, 2005Applicant: Bayer Technology Services GmbHInventors: Walter Schmitt, Stefan Willmann, Edgar Diessel, Ingmar Dorn, Jens Burmeister
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Publication number: 20040172230Abstract: Computer system for calculating a pharmacokinetic behavior of a chemical substance in insects, comprising:Type: ApplicationFiled: November 14, 2003Publication date: September 2, 2004Applicant: Bayer AktiengesellschaftInventors: Stefan Willmann, Walter Schmitt