Patents by Inventor Stefan Wohlfeil

Stefan Wohlfeil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyridines and 2-oxo-1,2-dihydropyridines
    Patent number: 5492923
    Abstract: Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: February 20, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Fey, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Thomas Kramer, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Siegfried Zaiss
  • Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives
    Patent number: 5478836
    Abstract: Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.
    Type: Grant
    Filed: March 11, 1994
    Date of Patent: December 26, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich E. Muller, Jurgen Dressel, Peter Fey, Rudolf H. Hanko, Walter Hubsch, Thomas Kramer, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil, Andreas Knorr, Johannes-Peter Stasch, Siegfried Zaiss
  • Sulphonylbenzyl-substituted imidazolypropenoic acid derivatives
    Patent number: 5475016
    Abstract: Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be prepared by reacting sulphonylbenzyl-substituted aldehydes with appropriate CH-acidic compounds and then dehydrating.The sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be used in medicaments, in particular for the treatment of high blood pressure and atherosclerosis.
    Type: Grant
    Filed: February 18, 1993
    Date of Patent: December 12, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Hanko, Jurgen Dressel, Peter Fey, Walter Hubsch, Thomas Kramer, Ulrich E. Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Claudia Hirth-Dietrich, Andreas Knorr, Johannes-Peter Stasch, Stefan Wohlfeil, Ozkan Yalkinoglu
  • Substituted derivatives of deoxymyoinositol, process for their preparation and their use in medicaments
    Patent number: 5463087
    Abstract: A process for the preparation of a compound. That compound is converted to a novel compound of the formula ##STR1## in which R.sup.1, R.sup.2 and R.sup.5 each independently is alkyl of 3 to 14 carbon atoms, which is used to make novel anti-inflammatories.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: October 31, 1995
    Assignee: Bayer Pharma
    Inventors: Erwin Bischoff, Zhan Gao, Stefan Wohlfeil, Gabriele Hecker, Jeannine Cleophax, Didier Dubreuil, Stephane Gero, Alice Olesker, Catherine Verre-Sebrie, Mauro Vieira de Almeida, Georges Vass
  • Imidazolyl-substituted phenylacetic acid prolinamides
    Patent number: 5459156
    Abstract: Imidazolyl-substituted phenylacetic acid prolinamides are prepared by reacting corresponding imidazolyl-substituted phenylacetic acids with prolines. The imidazolyl-substituted phenylacetic acid prolinamides can be used as active compounds in medicaments, preferably for the treatment of hypertension and atherosclerosis.
    Type: Grant
    Filed: January 27, 1994
    Date of Patent: October 17, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Matthias Muller-Gliemann, Jurgen Dressel, Peter Fey, Rudolf H. Hanko, Walter Hubsch, Thomas Kramer, Ulrich E. Muller, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil, Andreas Knorr, Johannes-Peter Stasch, Siegfried Zaiss
  • Imidazolyl-substituted phenylacetamides
    Patent number: 5420149
    Abstract: Imidazolyl-substituted phenylacetic acid derivatives are prepared by first reacting suitably substituted phenylacetic acid with imidazoles and subsequently converting the product into an amide. The compounds can be employed as active compounds in medicaments, in particular for treating hypertension and atherosclerosis.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: May 30, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich E. Muller, Matthias Muller-Gliemann, Jurgen Dressel, Peter Fey, Rudolf Hanko, Walter Husch, Thomas Kramer, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil, Ozkan Yalkinoglu, Andreas Knorr, Johannes-Peter Stasch, Ulrich Niewohner
  • Pyridinylmethyl-substituted pyridines and pyridones
    Patent number: 5414003
    Abstract: Pyridinylmethyl-substituted pyridines and pyridones are prepared by reacting pyridine- or pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substances according to the invention can be used as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: May 9, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Fey, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Thomas Kramer, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Siegfried Zaiss
  • Imidazolyl-substituted phenylpropionic and cinnamic acid derivatives
    Patent number: 5414008
    Abstract: Imidazolyl-substituted phenylpropionic and cinnamic acid derivatives are prepared by reacting appropriate benzyl compounds with imidazoles and optionally varying the substituents. The imidazolyl-substituted phenylpropionic and cinnamic acid derivatives can be used as active compounds in medicaments, in particular in the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: June 21, 1993
    Date of Patent: May 9, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich E. Muller, Jurgen Dressel, Peter Fey, Rudolf H. Hanko, Walter Hubsch, Thomas Kramer, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Andreas Knorr, Johannes-Peter Stasch, Stefan Wohlfeil
  • Biphenylmethyl-substituted pyridones
    Patent number: 5407942
    Abstract: Biphenylmethyl-substituted pyridones are prepared by reaction of pyridones with appropriate biphenylmethyl compounds.The biphenylmethyl-substituted pyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: May 5, 1993
    Date of Patent: April 18, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Dressel, Peter Fey, Rudolf H. Hanko, Walter Hubsch, Thomas Kramer, Ulrich E. Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil, Andreas Knorr, Johannes-Peter Stasch
  • Substituted derivatives of deoxymyoinositol, process for their preparation and their use in medicaments
    Patent number: 5407923
    Abstract: Substituted derivatives of deoxymyoinositol of general formula (I): ##STR1## in which R.sup.1, R.sup.2 and R.sup.5 are identical or different and represent a linear or branched alkyl group of 3 to 14 carbon atoms.R.sup.3 and R.sup.4 are identical or different and represent a hydrogen atom, a protecting group of the hydroxyl groups or the residue of formula --CO--(CH.sub.2).sub.n --CH.sub.3in whichn represents the number 12, 13, 14, 15, 16 or 17, and their salts, process for preparing them and their use in medicaments.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: April 18, 1995
    Assignee: Bayer Pharma
    Inventors: Erwin Bischoff, Zhan Gao, Stefan Wohlfeil, Gabriele Hecker, Jeannine Cleophax, Didier Dubreuil, Stephane Gero, Alice Olesker, Catherine Verre-Sebrie, Mauro V. de Almeida, Georges Vass
  • Substituted mono- and bipyridylmethylpyridones
    Patent number: 5407948
    Abstract: Substituted mono- and bipyridylmethylpyridones are prepared either by reaction of pyridones with mono- or bipyridylmethylhalogen compounds or by reaction of pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substituted mono- and bipyridylmethylpyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: May 6, 1994
    Date of Patent: April 18, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Fey, Walter Hubsch, Jurgen Dressel, Rudolf Hanko, Thomas Kramer, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Siegfried Zaiss
  • Heterocyclically substituted phenyl-cyclohexane-carboxylic acid derivatives
    Patent number: 5395840
    Abstract: Heterocyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting appropriate heterocyclic compounds with cyclohexanebenzyl halides.The compounds can be employed as active compounds in medicaments for the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: February 8, 1994
    Date of Patent: March 7, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich E. Muller, Jurgen Dressel, Peter Fey, Rudolf H. Hanko, Walter Hubsch, Thomas Kramer, Matthias Muller-Gliemann, Martin Beuck, Stanisiav Kazda, Stefan Wohlfeil, Andreas Knorr, Johannes-Peter Stasch, Siegfried Zaiss
  • Propenoyl-imidazole derivatives
    Patent number: 5376671
    Abstract: Propenoyl-imidazole derivatives are prepared by reaction of appropriate imidazoylaldehydes with CH-acidic compounds and subsequent dehydration of the intermediates. The propenoyl-imidazole derivatives can be employed as active compounds in medicaments for the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: April 6, 1993
    Date of Patent: December 27, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Matthias Muller-Gliemann, Jurgen Dressel, Peter Fey, Rudolf Hanko, Walter Hubsch, Thomas Kramer, Ulrich Muller, Martin Beuck, Stanislav Kazda, Andreas Knorr, Johannes-Peter Stasch, Stefan Wohlfeil
  • Sulphonylbenzyl-substituted imidazopyridines
    Patent number: 5364942
    Abstract: Sulphonylbenzyl-substituted imidazopyridines can be prepared by reacting correspondingly substituted imidazopyridines with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted imidazopyridines can be employed as active compounds in medicaments, in particular for the treatment of hypertension and atherosclerosis.
    Type: Grant
    Filed: February 18, 1993
    Date of Patent: November 15, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Hanko, Jurgen Dressel, Peter Fey, Walter Hubsch, Thomas Kramer, Ulrich E. Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Claudia Hirth-Dietrich, Andreas Knorr, Johannes-Peter Stasch, Stefan Wohlfeil, Ozkan Yalkinoglu
  • Substituted biphenylpyridones
    Patent number: 5356911
    Abstract: Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.
    Type: Grant
    Filed: November 2, 1992
    Date of Patent: October 18, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Stefan Wohlfeil, Walter Hubsch, Jurgen Dressel, Peter Fey, Rudolf Hanko, Thomas Kramer, Ulrich Muller, Siegfried Zaiss
  • Sulfonylbenzyl-substituted benzo- and pyridopyridones
    Patent number: 5354749
    Abstract: Sulfonylbenzyl-substituted benzo- and pyridopyridones are prepared by reacting corresponding benzo- and pyridopyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted benzo- and pyridopyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hyper tension and atherosclerosis.
    Type: Grant
    Filed: May 5, 1993
    Date of Patent: October 11, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Jurgen Dressel, Peter Fey, Rudolf H. Hanko, Walter Hubsch, Thomas Kramer, Ulrich E. Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil, Andreas Knorr, Johannes-Peter Stasch
  • Substituted phenylacetamides
    Patent number: 5352687
    Abstract: Substituted phenylacetamides can be prepared by reaction of appropriately substituted phenylacetic acids with imidazoles and subsequent amidation. The substituted phenylacetic acid derivatives can be employed in medicaments for the treatment of high blood pressure and atherosclerosis.
    Type: Grant
    Filed: March 3, 1993
    Date of Patent: October 4, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich E. Muller, Matthias Muller-Gliemann, Jurgen Dressel, Peter Fey, Rudolf Hanko, Walter Hubsch, Thomas Kramer, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil, Ozkan Yalkinoglu, Andreas Knorr, Johannes-Peter Stasch
  • Sulphonylbenzyl-substituted imidazoles
    Patent number: 5318980
    Abstract: Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary manner.The sulphonylbenzyl-substituted imidazoles can be used as active compounds in medicaments.
    Type: Grant
    Filed: February 18, 1993
    Date of Patent: June 7, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Hanko, Jurgen Dressel, Peter Fey, Walter Hubsch, Thomas Kramer, Ulrich E. Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Claudia Hirth-Dietrich, Andreas Knorr, Johannes-Peter Stasch, Stefan Wohlfeil, Ozkan Yalkinoglu
  • Imidazolyl-propenoic acid derivatives
    Patent number: 5294633
    Abstract: Imidazolyl-propenoic acid derivatives can be prepared by reaction of aldehydes with phosphonoacetic acid esters. The imidazolyl-propenoic acid derivatives are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.
    Type: Grant
    Filed: September 21, 1992
    Date of Patent: March 15, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Kramer, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Stefan Wohlfeil
  • Sulphonylbenzyl-substituted pyridones which are angiotension II receptor antagonists
    Patent number: 5254543
    Abstract: Sulphonylbenzyl-substituted pyridones can be prepared by reacting pyridones with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted pyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
    Type: Grant
    Filed: February 18, 1993
    Date of Patent: October 19, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rudolf Hanko, Walter Hubsch, Jurgen Dressel, Peter Fey, Thomas Kramer, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Claudia Hirth-Dietrich, Andreas Knorr, Johannes-Peter Stasch, Stefan Wohlfeil, Ozkan Yalkinoglu