Abstract: An elongate metallic heater element is provided for an aerosol-generating device, the heater element extending between proximal and distal ends, the proximal end configured for mounting to the device for electrical communication with the device, the heater element including either or both of: a plurality of surface notches formed on a surface of the heater element, and a plurality of sub-surface cavities defined beneath the surface of the heater element, at least some of the plurality of surface notches and the sub-surface cavities of the heater element are provided in an inner region of the heater element extending between the proximal end and 33% of a length of the heater element relative to the proximal end, and in which at least 40% by volume of all of the plurality of surface notches and the sub-surface cavities of the heater element are provided in the inner region.

Abstract: The invention relates to a beam analysis device (10) for determining the axial position of the focal point (71) of an energy beam or a sample beam (70) decoupled from an energy beam, comprising a beam-shaping device (12), a detector (40), and an analysis device (45). The beam-shaping device (12) is designed to release two sub-beams (72, 73) from the sample beam (70) on a plane of the sub-beam release process (19). The cross-sections of the two sub-beams (72, 73) are defined by sub-apertures (32, 33) which are delimited from each other and which are arranged at a distance k to each other in a first lateral direction (31). The beam-shaping device (12) is designed to image the two sub-beams (72, 73) in order to form two beam spots (92, 93) on the detector and deflect at least one of the two sub-beams (72, 73) in a second lateral direction (37) which is oriented transversely to the first lateral direction (31) in order to form a distance w in the second lateral direction (37) between the two beam spots (92, 93).

Abstract: The present invention relates to composition at least including (A) at least one epoxy-group terminated polyoxazolidinone, derived from at least one polyisocyanate compound and at least one aliphatic polyepoxide compound, (B) at least one compound having at least one group that is reactive towards terminal epoxy-groups, and (C) at least one solvent. The molar ratio of the epoxy groups of the polyepoxide compound to the isocyanate groups of the polyisocyanate compound is 50:1 to 2.4:1. The at least one epoxy-group terminated polyoxazolidinone is present in an amount of 50 to 95% by weight, in respect of the solid content of the composition. The sum of all components in respect of the solid content of the composition adds up to 100% by weight and where the solid content of the composition is at least 35% by weight.

Abstract: Transporting loads is a fundamental component of intralogistics. Autonomous industrial trucks can be used for this. The autonomous industrial truck claimed according to the invention is able, by means of the implemented navigation, load receiving and load placing methods, to ensure efficient transporting of loads. The invention relates to an autonomous industrial truck having a rearwardly-directed sensor unit for detecting the load and the loading environment and implemented process sequences for approaching the load, receiving the load and placing the load.

Abstract: The invention relates to a method and a device for the analysis of energy beams in systems for the additive manufacture of components (70) by means of layered solidification of a construction material (55) by an energy beam (30). The invention enables a determination of position-related beam data directly with respect to the processing point during the machining process. An additive manufacturing system includes a beam deflecting device (40), a processing plane (45), and a layer applicator (60). The device according to the invention comprises a movable beam barrier (17), a movable beam sampling module (20) and a measuring device (10) with a radiation detector (12).

Abstract: The invention relates to a beam analysis device (10) for determining the axial position of the focal point (71) of an energy beam or a sample beam (70) decoupled from an energy beam, comprising a beam-shaping device (12), a detector (40), and an analysis device (45). The beam-shaping device (12) is designed to modulate an intensity distribution (81) of the energy beam (77) or the decoupled sample beam (70) on a modulation plane (19) using a two-dimensional transmission function in order to form a modulated sample beam (79). The transmission function has at least two contrast stages (32, 33) with a distance a to each other in the form of transitions between at least one blocking region (25) and at least one passage region (21). The beam-shaping device (12) is designed to guide the modulated sample beam (79) onto the detector (40) along a propagation path in order to form the intensity distribution (83) on the detector (40) with at least two contrast features (92, 93) along the first lateral direction (31).

Abstract: The present invention is directed to cell-protective, in particular, cardio- and renal-protective organic compounds, preferably to organic compounds that inhibit substrate phosphorylation by the G-protein-coupled receptor kinase 2 (GRK2, ADRBK1). Preferably, the organic compounds inhibit the GRK2-mediated phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1, ASF-1, SF2) and/or phosducin for treating hypertension, heart diseases, heart dysfunction or failure and heart disease-associated pathologies, e.g. cardiomyocyte necrosis, ischemic cardiac disease and/or ischemic heart damage or ageing. Furthermore, the present invention is directed to a method for the identification of inhibitors of the (GRK2)-mediated phosphorylation of (SRSF1) and/or phosducin.

Abstract: The present disclosure relates to a beam analysis device for determining a light beam state, e.g., determining the focal position of a light beam, where the device has a partial beam imaging device having at least one first selection device for forming a first partial beam from a first partial aperture region of the first measurement beam, and an imaging device for imaging the first partial beam for generating a first beam spot onto a detector unit having a spatially-resolving detector. The beam analysis device also can have an evaluation unit for processing the signals of the detector unit, for determining a lateral position (a1) of the first beam spot, and for determining changes in the lateral position (a1, a1?) of the first beam spot over time. An optical system for focal position control with a laser optics and with a beam analysis device.

Abstract: An X-shaped spring device for a transportation vehicle wheel suspension having for each wheel side a first leaf spring and a second leaf spring made of fiber-reinforced plastics material and arranged one above the other. The first leaf spring is supported at the wheel side with one end and the second leaf spring is supported at the vehicle structure side with one end, and a first securing device on which the first leaf spring and the second leaf spring are joined and clamped, and which has a bearing for pivotable bearing at the vehicle structure side. The first securing devices of both wheel sides are connected to each other to provide a stabilizer action by using a spring.

Abstract: The invention relates to a method and an apparatus for the direct and precise measurement of the power and/or energy of a laser beam, which make a measurement possible even in areas close to the focus of a laser beam, A device is proposed for this purpose that contains a radiation sensor, an expansion device, and a support mount. The radiation sensor has a receiving surface and is configured for the generation of an electrical signal, which is dependent on the power of the laser beam or the energy of the laser beam. The expansion device and the radiation sensor are positioned on the support mount at a distance from one another. The expansion device is configured in such a way as to increase the angle range of the laser beam. The laser beam propagates to the radiation sensor with an increased angle range. A diameter of the laser beam propagated on the receiving surface is greater than a diameter of the laser beam in the area of the expansion device.

Abstract: An X-shaped spring device for a transportation vehicle wheel suspension having for each wheel side a first leaf spring and a second leaf spring made of fiber-reinforced plastics material and arranged one above the other. The first leaf spring is supported at the wheel side with one end and the second leaf spring is supported at the vehicle structure side with one end, and a first securing device on which the first leaf spring and the second leaf spring are joined and clamped, and which has a bearing for pivotable bearing at the vehicle structure side. The first securing devices of both wheel sides are connected to each other to provide a stabilizer action by using a spring.

Abstract: The invention relates to a method and an apparatus for the direct determination of spatial dimensions of a light beam with high precision and short measuring period, which are also suitable for the measuring of laser beams with high power in the range of the beam focus. For this purpose, an apparatus is proposed that includes a beam scanner, at least one light sensor, a movement device for the execution of a relative movement between the light beam and the beam scanner, and a device for the signal recording of a temporally variable signal of the light sensor. The beam scanner comprises at least one scanning body with at least three sampling areas, which extends along sampling lines. The sampling areas are configured for the extraction of linear or strip-shaped light samples from a cross-section of the light beam. Several scanning surfaces are defined by the sampling lines of the sampling areas, each spanned by a movement vector of the relative movement.

Abstract: A pellet column is formed in a metering duct. The lowermost pellet is located in a connection point where an outlet duct is connected to the metering duct and leads transversely away therefrom. A first duct, which opens into the metering duct via a first duct mouth above the connection point, is impinged with negative pressure, wherein a pellet is suctioned onto the first duct mouth and is fixed thereto. This pellet acts as a block for the pellets thereabove. A second duct, which opens into the connection point via a second duct mouth, is impinged with positive pressure, wherein the pellet at the connection point is pneumatically ejected via the outlet duct and supplied to a container. After the ejection of the lowermost pellet, the negative pressure in the first duct is switched off such that the pellet held at the first duct mouth advances toward the connection point.

Abstract: The invention relates to a method and an apparatus for the direct determination of spatial dimensions of a light beam with high precision and short measuring period, which are also suitable for the measuring of laser beams with high power in the range of the beam focus. For this purpose, an apparatus is proposed that includes a beam scanner (20), at least one light sensor (60), a movement device (50) for the execution of a relative movement between the light beam (10) and the beam scanner (20), and a device (64) for the signal recording of a temporally variable signal of the light sensor (60). The beam scanner (20) comprises at least one scanning body (21) with at least three sampling areas (22), which extends along sampling lines. The sampling areas (22) are configured for the extraction of linear or strip-shaped light samples from a cross-section (14) of the light beam (10).

Abstract: The invention relates to a method and an apparatus for the direct and precise measurement of the power and/or energy of a laser beam, which make a measurement possible even in areas close to the focus of a laser beam, A device is proposed for this purpose that contains a radiation sensor, an expansion device, and a support mount. The radiation sensor has a receiving surface and is configured for the generation of an electrical signal, which is dependent on the power of the laser beam or the energy of the laser beam, The expansion device and the radiation sensor are positioned on the support mount at a distance from one another. The expansion device is configured in such a way as to increase the angle range of the laser beam. The laser beam propagates to the radiation sensor with an increased angle range. A diameter of the laser beam propagated on the receiving surface is greater than a diameter of the laser beam in the area of the expansion device.

Abstract: The invention relates to a measuring probe for scanning light beams (10) or laser beams. The measuring probe is suitable for scanning laser beams with very high power and for determining geometric parameters of a light beam (10) with high spatial resolution. For this purpose, a device is proposed which comprises a body (20), a probe area (30) and a detector (40). The body (20) is made of an optically transparent material and has a light beam entry surface (22), a light beam exit surface (23) and a detection light exit surface (25). The light beam entry surface (22) and the light beam exit surface (23) are for the most part smooth and polished. The body (20) includes the probe area (30) having light-deflecting structuring. The detector (40) is designed to detect at least part of the beam portion (15) deflected from the light beam (10) by the probe area (30).

Abstract: The present invention is directed to cell-protective, in particular, cardio- and renal-protective organic compounds, preferably to organic compounds that inhibit substrate phosphorylation by the G-protein-coupled receptor kinase 2 (GRK2, ADRBK1). Preferably, the organic compounds inhibit the GRK2-mediated phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1, ASF-1, SF2) and/or phosducin for treating hypertension, heart diseases, heart dysfunction or failure and heart disease-associated pathologies, e.g. cardiomyocyte necrosis, ischemic cardiac disease and/or ischemic heart damage or ageing. Furthermore, the present invention is directed to a method for the identification of inhibitors of the (GRK2)-mediated phosphorylation of (SRSF1) and/or phosducin.

Abstract: The invention relates to a method and a device for the analysis of energy beams in systems for the additive manufacture of components (70) by means of layered solidification of a construction material (55) by an energy beam (30). The invention enables a determination of position-related beam data directly with respect to the processing point during the machining process. An additive manufacturing system includes a beam deflecting device (40), a processing plane (45), and a layer applicator (60). The device according to the invention comprises a movable beam barrier (17), a movable beam sampling module (20) and a measuring device (10) with a radiation detector (12). The method includes the following procedure steps. The beam barrier (17) and the beam sampling module (20) are positioned in the beam path between the beam deflecting device (40) and at least one selected processing coordinate (44) in the processing plane (45).

Abstract: A method and device for attaching a bone plate to a bone includes the steps of placing a first surface of a wire insertion device against the bone, inserting a reference wire through an opening of the wire insertion device extending therethrough from the first surface of the wire insertion device to a second surface of the wire insertion device, removing the wire insertion device from the reference wire and positioning a bone plate on the bone by moving the bone plate in a transverse direction relative to a longitudinal axis of the reference wire so that the reference wire is received within a slot of the bone plate, the bone plate including a first surface facing toward the bone and a second surface opposing the first surface, the slot open to a lateral side surface connecting edges of the first and second surfaces.

Abstract: Apparatus for determining geometrical parameters of a laser beam includes an optical system, a device for output coupling radiation, a beam diagnostic device, and a reflector element. The optical system focuses the laser beam into a processing region. The device for output coupling radiation couples out radiation that runs through the optical system in a direction opposite to a direction of the laser beam. The reflector element has a first surface which is partially reflecting and curved, where the curvature is equal to a mean curvature of a wave front of the laser beam in a positioning region of the reflector element.