Patents by Inventor Stefano Fontana
Stefano Fontana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11731946Abstract: The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.Type: GrantFiled: October 19, 2018Date of Patent: August 22, 2023Assignees: The General Hospital Corporation, Aptuit (Verona) SRL, An Evotec CompanyInventors: Laurence Rahme, Francois Lepine, Damien Maura, Carmela Napolitano, Antonio Felici, Michele Negri, Stefano Fontana, Daniele Andreotti
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Patent number: 11220277Abstract: A cable transportation system comprising: a first terminal station; a second terminal station; a plurality of transporting units moved between the terminal stations; at least one supporting cable for supporting the transporting units between the terminal stations; wherein the supporting cable comprises a first end housed inside the first terminal station and a second end housed inside the second terminal station; a first anchor device for anchoring the first end of the supporting cable inside the first terminal station; a second anchor device for anchoring the second end of the supporting cable inside the second terminal station; wherein the anchor devices are configured to selectively block the ends of the supporting cable inside the respective terminal stations and to enable a stepped sliding of the supporting cable between the terminal stations.Type: GrantFiled: July 29, 2019Date of Patent: January 11, 2022Assignee: LEITNER S.P.A.Inventors: Hartmut Wieser, Alexander Pechlaner, Stefano Fontana
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Publication number: 20210130306Abstract: The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.Type: ApplicationFiled: October 19, 2018Publication date: May 6, 2021Inventors: Laurence Rahme, Francois Lepine, Damien Maura, Carmela Napolitano, Antonio Felici, Michele Negri, Stefano Fontana, Daniele Andreotti
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Publication number: 20200163964Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.Type: ApplicationFiled: January 30, 2020Publication date: May 28, 2020Inventors: Giuseppe ALVARO, Anne DECOR, Stefano FONTANA, Dieter HAMPRECHT, Charles LARGE, Agostino MARASCO
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Patent number: 10632118Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.Type: GrantFiled: July 30, 2018Date of Patent: April 28, 2020Assignee: AUTIFONY THERAPEUTICS LIMITEDInventors: Giuseppe Alvaro, Anne Decor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
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Publication number: 20200039537Abstract: A cable transportation system comprising: a first terminal station; a second terminal station; a plurality of transporting units moved between the terminal stations; at least one supporting cable for supporting the transporting units between the terminal stations; wherein the supporting cable comprises a first end housed inside the first terminal station and a second end housed inside the second terminal station; a first anchor device for anchoring the first end of the supporting cable inside the first terminal station; a second anchor device for anchoring the second end of the supporting cable inside the second terminal station; wherein the anchor devices are configured to selectively block the ends of the supporting cable inside the respective terminal stations and to enable a stepped sliding of the supporting cable between the terminal stations.Type: ApplicationFiled: July 29, 2019Publication date: February 6, 2020Inventors: Hartmut Wieser, Alexander Pechlaner, Stefano Fontana
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Publication number: 20180338974Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.Type: ApplicationFiled: July 30, 2018Publication date: November 29, 2018Inventors: Giuseppe ALVARO, Anne Decor, Stefano fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
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Patent number: 10058551Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.Type: GrantFiled: October 2, 2017Date of Patent: August 28, 2018Assignee: Autifony Therapeutics LimitedInventors: Giuseppe Alvaro, Anne Decor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
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Publication number: 20180021336Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.Type: ApplicationFiled: October 2, 2017Publication date: January 25, 2018Inventors: Giuseppe ALVARO, Anne DECOR, Stefano FONTANA, Dieter HAMPRECHT, Charles LARGE, Agostino MARASCO
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Patent number: 9849131Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.Type: GrantFiled: November 10, 2016Date of Patent: December 26, 2017Assignee: AUTIFONY THERAPEUTICS LIMITEDInventors: Giuseppe Alvaro, Anne Decor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
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Publication number: 20170065585Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.Type: ApplicationFiled: November 10, 2016Publication date: March 9, 2017Inventors: Giuseppe ALVARO, Anne DECOR, Stefano FONTANA, Dieter HAMPRECHT, Charles LARGE, Agostino MARASCO
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Publication number: 20160058737Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.Type: ApplicationFiled: November 9, 2015Publication date: March 3, 2016Inventors: Giuseppe ALVARO, Anne DECOR, Stefano FONTANA, Dieter HAMPRECHT, Charles LARGE, Agostino MARASCO
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Patent number: 9216967Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.Type: GrantFiled: March 27, 2014Date of Patent: December 22, 2015Assignee: AUTIFONY THERAPEUTICS LIMITEDInventors: Giuseppe Alvaro, Anne Decor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
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Publication number: 20150018377Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.Type: ApplicationFiled: March 27, 2014Publication date: January 15, 2015Applicant: AUTIFONY THERAPEUTICS LIMITEDInventors: Giuseppe ALVARO, Anne Decor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
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Patent number: 8722695Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.Type: GrantFiled: December 6, 2010Date of Patent: May 13, 2014Assignee: Autifony Therapeutics LimitedInventors: Giuseppe Alvaro, Anne Décor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
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Publication number: 20120289526Abstract: The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.Type: ApplicationFiled: December 6, 2010Publication date: November 15, 2012Inventors: Giuseppe Alvaro, Anne Décor, Stefano Fontana, Dieter Hamprecht, Charles Large, Agostino Marasco
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Patent number: 8217168Abstract: The present invention relates to novel compounds of formula (I) or a salt thereof: wherein G is selected from a group consisting of: phenyl, a 5- or 6-membered monocyclic heteroaryl group, or a 8- to 11-membered heteroaryl bicyclic group; p is an integer ranging from 0 to 5; R1 is halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl and SF5; or corresponds to a group R6; and when p is an integer ranging from 2 to 5, each R1 may be the same or different; R2 is hydrogen or C1-4alkyl; n is 3, 4, 5 or 6; R6 is a moiety selected from the group consisting of: isoxazolyl, —CH2—N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2-pyrrolidinonyl, and such R6 group is optionally substituted by one or two substituents selected from: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl; R4 is selected in the group consisting of: hydrogen, halogen, hydroxy, cyano, C1-4alkyl, C3-7 cycloalkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanType: GrantFiled: October 1, 2008Date of Patent: July 10, 2012Assignee: Glaxo Group LimitedInventors: Barbara Bertani, Susanna Cremonesi, Stefano Fontana, Alessandra Pasquarello
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Publication number: 20100240661Abstract: The present invention relates to novel compounds of formula (I) or a salt thereof: wherein G is selected from a group consisting of: phenyl, a 5- or 6-membered monocyclic heteroaryl group, or a 8- to 11-membered heteroaryl bicyclic group; p is an integer ranging from 0 to 5; R1 is halogen, hydroxy, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanoyl and SF5; or corresponds to a group R6; and when p is an integer ranging from 2 to 5, each R1 may be the same or different; R2 is hydrogen or C1-4alkyl; n is 3, 4, 5 or 6; R6 is a moiety selected from the group consisting of: isoxazolyl, —CH2—N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl, 2-pyrrolidinonyl, and such R6 group is optionally substituted by one or two substituents selected from: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl; R4 is selected in the group consisting of: hydrogen, halogen, hydroxy, cyano, C1-4alkyl, C3-7 cycloalkyl, haloC1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, C1-4alkanType: ApplicationFiled: October 1, 2008Publication date: September 23, 2010Inventors: Barbara Bertani, Susanna Cremonesi, Stefano Fontana, Alessandra Pasquarello