Patents by Inventor Steffen Guenther
Steffen Guenther has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240174683Abstract: The present invention relates to Map4K1 inhibitors of formula (I) (I), wherein A, E, G, Q, R1, R2 and R4 have the same meaning as defined in the description, to pharmaceutical compositions and combinations comprising the compounds according to the invention, and to the prophylactic and therapeutic use of the inventive compounds, respectively to the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for neoplastic disorders, respectively cancer or conditions with dysregulated immune responses or other disorders associated with aberrant MAP4K1 signaling, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: February 4, 2022Publication date: May 30, 2024Applicants: Bayer Aktiengesellschaft, Deutsches KrebsforschungszentrumInventors: Ulrich LÜCKING, Jeffrey Stuart MOWAT, Ludwig ZORN, Lars WORTMANN, Steffen MÜLLER, Gabriele LEDER, Sandra BERNDT, Judith GÜNTHER, Lara KUHNKE, Antje Margret WENGNER, Rafael CARRETERO, Gerd WOHLFAHRT, Anders FRIBERG, Ulf BÖMER, Roland NEUHAUS, Maren OSMERS, Hideki Miyatake ONDOZABAL, Martina SCHÄFER, Louise EAGLING, Julien LEFRANC, Katrin NOWAK-REPPEL, Rienk OFFRINGA, Peng CHEN, Xuewei WANG, Yuanyuan YAN, Kai THEDE, Nikolay SITNIKOV, Berndt BUCHMANN, Dirk KOSEMUND, Detlef STOECKIGT
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Publication number: 20240094319Abstract: There is provided a method of determining a scan sequence for magnetic resonance imaging—MRI. The method comprises: receiving an indication of one or more selected imaging parameters for the MRI; and based on the selected imaging parameters, determining the scan sequence usable by an MRI apparatus to perform the MRI, wherein determining the scan sequence comprises configuring the scan sequence to modulate gradient noise arising from the MRI apparatus during the MRI to deliver a first audible signal to the patient, wherein the first audible signal is configured to perform auditory stimulation of slow wave activity in the patient.Type: ApplicationFiled: January 18, 2022Publication date: March 21, 2024Inventors: Mark Thomas Johnson, Steffen Weiss, Marieke Van Dooren, Jan Hendrik Wuelbern, Christoph Günther Leussler, Rajendra Singh Sisodia
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Patent number: 10907249Abstract: Methods and apparatuses for coating a flexible substrate are provided. The flexible substrate is guided over a process roller. The flexible substrate has a first protective film, which is removed from the flexible substrate before the flexible substrate reaches a coating zone of a coating device located opposite the process roller. The first protective film is removed from the flexible substrate after the flexible substrate has formed a mechanical contact with the surface of the process roller. A second protective film is applied to the coated side of the flexible substrate after the flexible substrate has left the coating zone of the coating device and before the mechanical contact between the process roller and the flexible substrate is ended.Type: GrantFiled: June 8, 2017Date of Patent: February 2, 2021Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Matthias Fahland, Uwe Meyer, Tobias Vogt, Steffen Günther, John Fahlteich, Nicole Prager
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Patent number: 10557196Abstract: A method for reducing the adhesion of dirt to a substrate is provided, where a thin, incompletely closed layer of a material is deposited on at least one surface area of the substrate by means of a vacuum deposition process, and then said surface area is acted upon by accelerated ions.Type: GrantFiled: September 10, 2015Date of Patent: February 11, 2020Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Steffen Günther, Cindy Steiner, Jörg Kubusch
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Publication number: 20190256971Abstract: Methods and apparatuses for coating a flexible substrate are provided. The flexible substrate is guided over a process roller. The flexible substrate has a first protective film, which is removed from the flexible substrate before the flexible substrate reaches a coating zone of a coating device located opposite the process roller. The first protective film is removed from the flexible substrate after the flexible substrate has formed a mechanical contact with the surface of the process roller. A second protective film is applied to the coated side of the flexible substrate after the flexible substrate has left the coating zone of the coating device and before the mechanical contact between the process roller and the flexible substrate is ended.Type: ApplicationFiled: June 8, 2017Publication date: August 22, 2019Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Matthias FAHLAND, Uwe MEYER, Tobias VOGT, Steffen GÜNTHER, John FAHLTEICH, Nicole PRAGER
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Publication number: 20180321424Abstract: A method for the production of nanoscopic and/or microscopic surface structures on a flat substrate is provided, wherein the surface structure of the substrate is changed through the use of an ion etching process. First, a coating that features a boundary surface-active substance with a concentration of 0.01 to 5 percent by weight is applied to the substrate. The coating applied to the substrate is subsequently transformed into a solid form, and the ion etching process is then performed.Type: ApplicationFiled: May 1, 2018Publication date: November 8, 2018Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Cindy Steiner, Juliane Fichtner, Steffen Günther, Volker Kirchhoff
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Publication number: 20180216230Abstract: A method for depositing a graphene-based layer on a substrate by means of chemical vapor deposition is provided in which at least one hydrocarbon is introduced into a vacuum chamber as a starting material for a chemical reaction and, concurrently, a plasma is formed inside the vacuum chamber. In this case, at least one magnetron is used to generate the plasma, where the magnetron comprises at least one target of a material comprising at least one catalytically active metal selected from the group of chemical elements having the atomic numbers 21 to 30, 39 to 48, 57, 72 to 80 and 89; and where the sputtering of the target is set in such a way that the fraction of target particles, embedded in the graphene-based layer, is less than 1 at %.Type: ApplicationFiled: July 13, 2016Publication date: August 2, 2018Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Katrin WALD, Matthias FAHLAND, Steffen GÜNTHER, Nicolas SCHILLER
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Patent number: 9771650Abstract: Methods are provided for modifying a transparent and electrically conductive metal-oxide coating deposited on a plastic substrate. At least one surface region of the metal oxide coating is impinged by a pulse-driven electron beam. The impingement of the surface region of the metal oxide coating by the pulse-driven electron beam occurs inside a vacuum chamber into which hydrogen, argon, nitrogen, or oxygen, or a gas mixture of at least two of the above-mentioned gasses has been introduced.Type: GrantFiled: August 25, 2016Date of Patent: September 26, 2017Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Vincent Fischer, Benjamin Graffel, Falk Winckler, Björn Meyer, Matthias Fahland, Steffen Günther
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Publication number: 20170218504Abstract: A method for reducing the adhesion of dirt to a substrate is provided, where a thin, incompletely closed layer of a material is deposited on at least one surface area of the substrate by means of a vacuum deposition process, and then said surface area is acted upon by accelerated ions.Type: ApplicationFiled: September 10, 2015Publication date: August 3, 2017Inventors: Steffen Günther, Cindy Steiner, Jörg Kubusch
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Publication number: 20170067148Abstract: Methods are provided for modifying a transparent and electrically conductive metal-oxide coating deposited on a plastic substrate. At least one surface region of the metal oxide coating is impinged by a pulse-driven electron beam. The impingement of the surface region of the metal oxide coating by the pulse-driven electron beam occurs inside a vacuum chamber into which hydrogen, argon, nitrogen, or oxygen, or a gas mixture of at least two of the above-mentioned gasses has been introduced.Type: ApplicationFiled: August 25, 2016Publication date: March 9, 2017Inventors: Vincent Fischer, Benjamin Graffel, Falk Winckler, Björn Meyer, Matthias Fahland, Steffen Günther
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Publication number: 20150184278Abstract: The present invention provides a coated plastics film with a zinc tin oxide coating which has improved absorption property, in particular in the blue spectral range from 380 to 430 nm, the zinc tin oxide coating itself and a process for the production thereof, and an electronic device comprising a corresponding coated plastics film.Type: ApplicationFiled: May 28, 2013Publication date: July 2, 2015Applicant: Bayer MaterialScience AGInventors: Peter Reichert, Steffen Günther, Tobias Vogt
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Publication number: 20140374241Abstract: A method for depositing a LiPON coating on a substrate is provided, wherein the vaporization material, which is located in a vessel and which includes at least the chemical elements lithium, phosphorus and oxygen, is vaporized within a vacuum chamber. Here the vaporization material is heated by means of a thermal vaporization apparatus, and simultaneously either a nitrogen-containing component is introduced into the vacuum chamber or a nitrogen-containing material is co-vaporized, and wherein the vapor particle mist rising from the vessel is permeated by a plasma before the deposition on the substrate.Type: ApplicationFiled: January 16, 2013Publication date: December 25, 2014Inventors: Steffen Günther, Matthias Fahland, Henry Morgner, Steffen Straach, Björn Meyer
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Patent number: 8625201Abstract: An optical element for distributing light has a predefined spectral energy distribution in a predetermined working wavelength range. The optical element encompasses a transparent body into which the light enters, and a beam splitter layer embodied inside the transparent body, which layer has in the working wavelength range a predefined wavelength-dependent reflectance with which it reflects the light entering the transparent body in order to generate a reflected exit light bundle, and a wavelength-dependent transmittance with which it transmits the light entering the transparent body to generate a transmitted exit light bundle. The optical element encompasses a compensation layer arrangement, embodied on the transparent body separately from the beam splitter layer, whose transmittance with regard to the light passing through the compensation layer arrangement is defined as a function of the reflectance and transmittance of the beam splitter layer.Type: GrantFiled: November 15, 2011Date of Patent: January 7, 2014Assignee: Leica Microsystems CMS GmbHInventors: Frank Eisenkraemer, Steffen Guenther, Hans-Martin Heuck
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Publication number: 20130302536Abstract: The invention relates to a method for producing a transparent bather layer system, wherein in a vacuum chamber at least two transparent barrier layers and a transparent intermediate layer disposed between the two barrier layers are deposited on a transparent plastic film, wherein for deposition of the barrier layers aluminium is vaporised and simultaneously at least one first reactive gas is introduced into the vacuum chamber and wherein for deposition of the intermediate layer aluminium is vaporised and simultaneously at least one second reactive gas and a gaseous or vaporous organic component are introduced into the vacuum chamber.Type: ApplicationFiled: February 15, 2012Publication date: November 14, 2013Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Steffen Guenther, Bjoern Meyer, Steffen Straach, Thomas Kuehnel, Sebastian Bunk, Nicolas Schiller
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Publication number: 20130287969Abstract: The invention relates to a method for producing a transparent barrier layer system, wherein in a vacuum chamber at least two transparent barrier layers and a transparent intermediate layer disposed between the two barrier layers are deposited on a transparent plastic film, wherein for deposition of the barrier layers aluminium is vaporised and simultaneously at least one first reactive gas is introduced into the vacuum chamber and wherein for deposition of the intermediate layer aluminium is vaporised and simultaneously at least one second reactive gas is introduced into the vacuum chamber, and a silicon-containing layer is deposited as intermediate layer by means of a PECVD process.Type: ApplicationFiled: February 15, 2012Publication date: October 31, 2013Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Steffen Guenther, Bjoern Meyer, Steffen Straach, Thomas Kuehnel, Sebastian Bunk, Nicolas Schiller
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Patent number: 8535810Abstract: A transparent plastic film for screening electromagnetic waves includes a transparent film substrate and a layer system comprising at least one silver layer and two niobium oxide layers. The silver layer is embedded between the two niobium oxide layers.Type: GrantFiled: October 16, 2008Date of Patent: September 17, 2013Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.Inventors: Matthias Fahland, Tobias Vogt, Nicolas Schiller, Waldemar Schoenberger, Steffen Guenther, John Fahlteich
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Publication number: 20130149445Abstract: The invention relates to a method for producing a firm bond between a polymer substrate and an inorganic layer, wherein the substrate surface is exposed to a precursor before the deposition of the inorganic layer which is to be produced by means of a PVD process.Type: ApplicationFiled: June 14, 2011Publication date: June 13, 2013Inventors: Steffen Guenther, Bjoern Meyer
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Publication number: 20120120500Abstract: An optical element (10, 50, 60) encompasses a transparent body (12) and a beam splitter layer (18) embodied inside the transparent body (12), which layer has in a working wavelength range a predefined wavelength-dependent reflectance with which it reflects the light entering the transparent body (12), and a wavelength-dependent transmittance with which it transmits the light entering the transparent body (12). The optical element (10, 50, 60) further encompasses a compensation layer arrangement (28, 30, 52, 54), whose transmittance with regard to the light passing through the compensation layer arrangement (28, 30, 52, 54) is defined in such a way that the reflected exit light bundle and the transmitted exit light bundle have matching spectral energy distributions.Type: ApplicationFiled: November 15, 2011Publication date: May 17, 2012Applicant: LEICA MICROSYSTEMS CMS GMBHInventors: Frank Eisenkraemer, Steffen Guenther, Hans-Martin Heuck
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Publication number: 20110091662Abstract: The invention relates to a method and a device for the plasma-enhanced deposition of a layer on a substrate (12) by means of a chemical reaction inside a vacuum chamber (11), wherein at least one starting material of the chemical reaction is guided into the vacuum chamber (11) through an inlet (13), and wherein the inlet (13) is connected as an electrode of a gas discharge at least in the region of the inlet opening (18). A magnetron can also be used in the reactive sputtering method.Type: ApplicationFiled: May 15, 2009Publication date: April 21, 2011Inventors: Matthias Fahland, Tobias Vogt, Steffen Guenther, John Fahlteich, Waldemar Schoenberger, Alexander Schoenberger
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Publication number: 20100307812Abstract: The invention relates to a transparent plastic film for screening electromagnetic waves, comprising a transparent film substrate and a layer system that has at least one silver layer, as well as a method for producing a plastic film of this type, wherein the silver layer is embedded between two niobium oxide layers.Type: ApplicationFiled: October 16, 2008Publication date: December 9, 2010Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANInventors: Matthias Fahland, Tobias Vogt, Nicolas Schiller, Waldemar Schoenberger, Steffen Guenther, John Fahlteich