Abstract: The present invention is directed to an enriched preparation of multipotent mesenchymal cells obtained from human hair follicle stem cells, preferably adult human hair follicle cells. These cells can be differentiated into adipogenic, chondrogenic and osteogenic cells as well as smooth muscle cells. The present invention is also directed to a method of producing a tissue-engineered vascular vessel containing the preparation of isolated smooth muscle cells or progenitors thereof. The resulting tissue-engineered vascular vessel and a method of producing a tissue-engineered vascular vessel for a particular patient are also disclosed.

Abstract: A method of producing a tissue-engineered vascular vessel by providing a vessel-forming mixture of fibrinogen, thrombin, and cells, molding the vessel-forming mixture into a fibrin gel having a tubular shape, and incubating the fibrin gel in a medium suitable for growth of the cells. The resulting tissue-engineered vascular vessel and a method of producing a tissue-engineered vascular vessel for a particular patient are also disclosed.