Patents by Inventor Stella Defiore

Stella Defiore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline and amorphous forms of Olaparib
    Patent number: 9981951
    Abstract: Disclosed are a novel crystalline form and an amorphous form of Olaparib, and the process for their preparation.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: May 29, 2018
    Assignee: OLON S.P.A.
    Inventors: Barbara Novo, Jacopo Bonanomi, Stella Defiore, Francesco Calogero
  • Efficient method for the preparation of tofacitinib citrate
    Patent number: 9828380
    Abstract: Disclosed is a novel process for the synthesis of tofacitinib citrate on an industrial scale with high yields and purity starting with cis-(1-benzyl-4-methyl-piperidin-3-yl)methylamine bis-hydrochloride racemate (intermediate VIII), which comprises: 1. Condensation between intermediates VII and VIII to give intermediate VI 2. Hydrogenation of intermediate VI to give intermediate V 3. Resolution of intermediate V to give intermediate IV with enantiomeric purity >99% 4. Release of intermediate IV in a basic medium to give intermediate III 5. N-acylation reaction of intermediate III to give II (tofacitinib) 6.
    Type: Grant
    Filed: April 7, 2016
    Date of Patent: November 28, 2017
    Assignee: OLON S.P.A.
    Inventors: Jacopo Bonanomi, Stella Defiore, Barbara Novo
  • CRYSTALLINE AND AMORPHOUS FORMS OF OLAPARIB
    Publication number: 20170174662
    Abstract: Disclosed are a novel crystalline form and an amorphous form of Olaparib, and the process for their preparation.
    Type: Application
    Filed: December 19, 2016
    Publication date: June 22, 2017
    Inventors: Barbara Novo, Jacopo Bonanomi, Stella Defiore, Francesco Calogero
  • EFFICIENT METHOD FOR THE PREPARATION OF TOFACITINIB CITRATE
    Publication number: 20160297825
    Abstract: Disclosed is a novel process for the synthesis of tofacitinib citrate on an industrial scale with high yields and purity starting with cis-(1-benzyl-4-methyl-piperidin-3-yl)methylamine bis-hydrochloride racemate (intermediate VIII), which comprises: 1. Condensation between intermediates VII and VIII to give intermediate VI 2. Hydrogenation of intermediate VI to give intermediate V 3. Resolution of intermediate V to give intermediate IV with enantiomeric purity >99% 4. Release of intermediate IV in a basic medium to give intermediate III 5. N-acylation reaction of intermediate III to give II (tofacitinib) 6.
    Type: Application
    Filed: April 7, 2016
    Publication date: October 13, 2016
    Inventors: Jacopo Bonanomi, Stella Defiore, Barbara Novo