Patents by Inventor Stephanie Barbosa

Stephanie Barbosa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of kinases
    Patent number: 7820814
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: October 26, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Rajeev S. Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa, Louis Lombardo, Jeffrey Robl
  • NOVEL INHIBITORS OF KINASES
    Publication number: 20090170853
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: March 6, 2009
    Publication date: July 2, 2009
    Inventors: Rajeev S. Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa, Louis Lombardo, Jeffrey Robl
  • Inhibitors of kinases
    Patent number: 7521450
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: April 21, 2009
    Assignee: Bristol-Myers Squibb Company
    Inventors: Rajeev S. Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa, Louis Lombardo, Jeffrey Robl
  • Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
    Patent number: 7432373
    Abstract: The present invention is directed to intermediates that are useful for preparing pyrrolotriazines, and processes for preparing such intermediates.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: October 7, 2008
    Assignee: Bristol-Meyers Squibb Company
    Inventors: Gerard Crispino, Stephanie Barbosa, Junying Fan, Zhen-wei Cai
  • NOVEL INHIBITORS OF KINASES
    Publication number: 20070299075
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: August 2, 2007
    Publication date: December 27, 2007
    Inventors: Rajeev Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa, Louis Lombardo, Jeffrey Robl
  • Inhibitors of kinases
    Patent number: 7265113
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: January 13, 2005
    Date of Patent: September 4, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Rajeev S. Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa, Louis Lombardo, Jeffrey Robl
  • Pyrrolotriazine kinase inhibitors
    Patent number: 7102002
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: September 5, 2006
    Assignee: Bristol-Myers Squibb Company
    Inventors: Zhen-wei Cai, Louis J. Lombardo, Rajeev S. Bhide, Ligang Qian, Donna D. Wei, Stephanie Barbosa
  • Pyrrolotriazine kinase inhibitors
    Publication number: 20060009454
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: June 14, 2005
    Publication date: January 12, 2006
    Inventors: Zhen-wei Cai, Louis Lombardo, Rajeev Bhide, Ligang Qian, Donna Wei, Stephanie Barbosa
  • Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
    Publication number: 20050288289
    Abstract: The present invention is directed to intermediates that are useful for preparing pyrrolotriazines, and processes for preparing such intermediates.
    Type: Application
    Filed: June 24, 2005
    Publication date: December 29, 2005
    Inventors: Gerard Crispino, Stephanie Barbosa, Junying Fan, Zhen-wei Cai
  • Process for preparing certain pyrrolotriazine compounds
    Patent number: 6933386
    Abstract: The present invention relates to a process for preparing certain pyrrolotriazine compounds of the formula and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: August 23, 2005
    Assignee: Bristol Myers Squibb Company
    Inventors: Rajeev S. Bhide, Junying Fan, Luca Parlanti, Stephanie Barbosa, Ligang Qian, Zhen-Wei Cai, Francis S. Gibson
  • Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
    Publication number: 20050159420
    Abstract: Disclosed are pyrrolopyridazine compounds, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and other disorders.
    Type: Application
    Filed: January 5, 2005
    Publication date: July 21, 2005
    Inventors: Mark Salvati, Stephanie Barbosa, Zhong Chen, John Hunt
  • Novel inhibitors of kinases
    Publication number: 20050124621
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: January 13, 2005
    Publication date: June 9, 2005
    Inventors: Rajeev Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa, Louis Lombardo, Jeffrey Robl
  • Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
    Patent number: 6900208
    Abstract: Disclosed are pyrrolopyridazine compounds of the formula, wherein the substituents are defined herein, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and other disorders.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: May 31, 2005
    Assignee: Bristol Myers Squibb Company
    Inventors: Mark Salvati, Stephanie A. Barbosa, Zhong Chen, John T. Hunt
  • Pyrrolo[2,1-f][1,2,4]triazine inhibitors of kinases
    Patent number: 6869952
    Abstract: The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: July 18, 2003
    Date of Patent: March 22, 2005
    Assignee: Bristol Myers Squibb Company
    Inventors: Rajeev S. Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa
  • Process for preparing certain pyrrolotriazine compounds
    Publication number: 20040077858
    Abstract: The present invention relates to a process for preparing certain pyrrolotriazine compounds of the formula 1
    Type: Application
    Filed: July 18, 2003
    Publication date: April 22, 2004
    Inventors: Rajeev S. Bhide, Junying Fan, Luca Parlanti, Stephanie Barbosa, Ligang Qian, Zhen-Wei Cai, Francis S. Gibson
  • Novel inhibitors of kinases
    Publication number: 20040072832
    Abstract: The present invention provides compounds of formula I, 1
    Type: Application
    Filed: July 18, 2003
    Publication date: April 15, 2004
    Inventors: Rajeev S. Bhide, Zhen-Wei Cai, Ligang Qian, Stephanie Barbosa
  • Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
    Publication number: 20040063712
    Abstract: Disclosed are pyrrolopyridazine compounds, methods of preparing such compounds, and their use for the treatment of proliferative, inflammatory, and other disorders.
    Type: Application
    Filed: March 25, 2003
    Publication date: April 1, 2004
    Inventors: Mark Salvati, Stephanie A. Barbosa, Zhong Chen, John T. Hunt