Patent number: 9322000
Abstract: The present invention relates to a nucleic acid molecule, which encodes a polypeptide having alcohol dehydrogenase activity, in particular methanol dehydrogenase activity, comprising having a nucleotide sequence selected from the group consisting of: (i) a nucleotide sequence as set forth in any one of SEQ ID NOs: 1 (mdh2-MGA3), 3 (mdh3-MGA3), or 5 (mdh2-PB1); (ii) a nucleotide sequence having at least 90% sequence identity, more particularly at least 91, 92, 93, 94, 95, 96, 97, 98 or 99% sequence identity, with a nucleotide sequence as set forth in any one of SEQ ID NOs: 1, 3 or 5; (iii) a nucleotide sequence which is degenerate with any one of the nucleotide sequences of SEQ ID NOs: 1, 3 or 5; (iv) a nucleotide sequence which is a part of the nucleotide sequence of any one of SEQ ID NOs: 1, 3 or 5, or of a nucleotide sequence which is degenerate with a sequence of SEQ ID NOs: 1, 3 or 5; (v) a nucleotide sequence encoding all or part of a polypeptide whose amino acid sequence is set forth in any one of SEQ I
Type:
Grant
Filed:
January 25, 2013
Date of Patent:
April 26, 2016
Assignees:
SINTEF TTO AS, ETH ZURICH, RIJKSUNIVERSITEIT GRONINGEN
Inventors:
Trygve Brautaset, Tonje Marita Bjerkan Heggeset, Anne Krog, Wilhelmus Johannes Quax, Mark Jan Jacobus Bernhard Sibbald, Julia Vorholt, Jonas Müller, Patrick Kiefer, Eva Potthoff, Volker F Wendisch, Lennart Lessmeier, Stéphanie Heux, Jean-Charles Portais
Publication number: 20150267177
Abstract: The present invention relates to a nucleic acid molecule, which encodes a polypeptide having alcohol dehydrogenase activity, in particular methanol dehydrogenase activity, comprising having a nucleotide sequence selected from the group consisting of: (i) a nucleotide sequence as set forth in any one of SEQ ID NOs: 1 (mdh2-MGA3), 3 (mdh3-MGA3), or 5 (mdh2-PB1); (ii) a nucleotide sequence having at least 90% sequence identity, more particularly at least 91, 92, 93, 94, 95, 96, 97, 98 or 99% sequence identity, with a nucleotide sequence as set forth in any one of SEQ ID NOs: 1, 3 or 5; (iii) a nucleotide sequence which is degenerate with any one of the nucleotide sequences of SEQ ID NOs: 1, 3 or 5; (iv) a nucleotide sequence which is a part of the nucleotide sequence of any one of SEQ ID NOs: 1, 3 or 5, or of a nucleotide sequence which is degenerate with a sequence of SEQ ID NOs: 1, 3 or 5; (v) a nucleotide sequence encoding all or part of a polypeptide whose amino acid sequence is set forth in any one of SEQ I
Type:
Application
Filed:
January 25, 2013
Publication date:
September 24, 2015
Inventors:
Trygve Brautaset, Tonje Marita Bjerkan Heggeset, Anne Krog, Wilhelmus Johannes Quax, Mark Jan Jacobus Bernhard Sibbald, Julia Vorholt, Jonas Mueller, Patrick Kiefer, Eva Potthoff, Volker F. Wendisch, Lennart Lessmeier, Stéphanie Heux, Jean-Charles Portais