Abstract: Disclosed are 2,8-diazaspiro[4.5]decane compounds, including (pyrido[3,4-d]pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane compounds, (2,6-naphthyridin-1-yl)-2,8-diazaspiro[4.5]decane compounds, and (1,7-naphthyridin-4-yl)-2,8-diazaspiro[4.5]decane compounds, that are inhibitors of LATS1/2, compositions containing these compounds, and methods for inhibiting LATS1/2 activity.

Abstract: The present disclosure generally relates to methods for sending event notifications. In some examples, a controller periodically sends messages concerning a status of an event corresponding to the controller. In some examples, at a first time while periodically sending the messages and in accordance with a determination that the status of the event has changed, the controller sends a message concerning data other than the status of the event. In some examples, at the first time while periodically sending the messages and in accordance with a determination that the status of the event has not changed, the controller continues to periodically send the messages without sending the message concerning data other than the status of the event.

Abstract: A detection layer (416) for a radiation detector (400) includes a porous silicon membrane (418). The porous silicon membrane includes silicon (419) with a first side (430) and a second opposing side (432), a plurality of pores (420) extending entirely through the silicon from the first side to the second opposing side, each including shared walls (426), at least one protrusion of silicon (424) protruding out and extending from the first side a distance (504, 604, 704). The porous silicon membrane further includes a plurality of radiation sensitive quantum dots (422) in the pores and a quantum dot layer disposed on the first side and having a surface (434) and a thickness (506, 606, 706), wherein the thickness is greater than the distance.

Abstract: A radiation detector (100) includes a photovoltaic layer (102) with first and second opposing sides. The photovoltaic layer is configured to absorb first radiation at the first side and produce electrical charge. The detector further includes a porous silicon quantum dot layer (104) disposed at the second side of the photovoltaic layer and configured to receive second radiation and convert the received second radiation into an electrical signal indicative of an energy level of the received second radiation. The detector further includes an acquisition and communication layer (106) disposed adjacent to the porous silicon quantum dot layer and configured to receive the electrical signal and transmit the electrical signal to a device remote from the radiation detector.

Abstract: Among other things, we describe techniques for implementing a vehicle response to sensor failure. In general, one innovative aspect of the subject matter described in this specification can be embodied in methods that include receiving information from a plurality of sensors coupled to a vehicle, determining that a level of confidence of the received information from at least one sensor of a first subset of sensors of the plurality of sensors is less than a first threshold, comparing a number of sensors in the first subset of sensors to a second threshold, and adjusting the driving capability of the vehicle to rely on information received from a second subset of sensors of the plurality of sensors, wherein the second subset of sensors excludes the at least one sensor of the first subset of sensors.

Abstract: Among other things, we describe techniques for implementing a vehicle response to sensor failure. In general, one innovative aspect of the subject matter described in this specification can be embodied in methods that include receiving information from a plurality of sensors coupled to a vehicle, determining that a level of confidence of the received information from at least one sensor of a first subset of sensors of the plurality of sensors is less than a first threshold, comparing a number of sensors in the first subset of sensors to a second threshold, and adjusting the driving capability of the vehicle to rely on information received from a second subset of sensors of the plurality of sensors, wherein the second subset of sensors excludes the at least one sensor of the first subset of sensors.

Abstract: An apparatus is provided which includes a processing circuit and a plurality of sensors connected to a vehicle, where at least one of the plurality of sensors is positioned on an undercarriage of the vehicle. The plurality of sensors can detect variations in a road on which the vehicle is traveling. The plurality of sensors can also generate information corresponding to the variations of the road. The plurality of sensors can also transmit the information corresponding to the variations in the road to the processing circuit. The information collected by the plurality of sensors may then be used to augment a driving capability of the vehicle.

Abstract: The present invention provides a method of preparing D-psicose comprising the steps of (i) providing a mixture of D-psicose and D-fructose; and (ii) contacting the mixture of D-psicose and D-fructose with a probiotic microorganism that is capable of metabolizing D-fructose but not D-psicose and capable of converting D-fructose into L-lactic acid and subjecting the microorganism to culture conditions that allow fermentative removal of D-fructose from the mixture of D-psicose and D-fructose with concomitant production of L-lactic acid. Further provided are uses of a probiotic microorganism that is capable of metabolizing D-fructose but not D-psicose and capable of converting D-fructose into L-lactic acid for fermentative removal of D-fructose from a mixture of D-psicose and D-fructose. In particular, the probiotic microorganism is Lactobacillus rhamnosus GG or Saccharomyces boulardii.

Abstract: A detection layer (416) for a radiation detector (400) includes a porous silicon membrane (418). The porous silicon membrane includes silicon (419) with a first side (430) and a second opposing side (432), a plurality of pores (420) extending entirely through the silicon from the first side to the second opposing side, each including shared walls (426), at least one protrusion of silicon (424) protruding out and extending from the first side a distance (504, 604, 704). The porous silicon membrane further includes a plurality of radiation sensitive quantum dots (422) in the pores and a quantum dot layer disposed on the first side and having a surface (434) and a thickness (506, 606, 706), wherein the thickness is greater than the distance.

Abstract: An imaging module (114) of an imaging system comprises a porous silicon membrane (116) with a first side (208), a contact side (210) opposite the first side, columns of silicon (212) configured to extend from the first side to the contact side, and columnar holes (214, 502) interlaced with the columns of silicon and configured to extend from the first side to the contact side. The imaging module further includes quantum dots (118) in the columnar holes. The imaging module further includes a metal pad (120) electrically coupled to the columns of silicon of the porous silicon membrane. The quantum dots in the columnar holes are electrically insulated from the metal pad. The imaging module further includes a substrate (122) with an electrically conductive pad (204) in electrical communication with the metal pad that defines a pixel.

Abstract: An apparatus is provided which includes a processing circuit and a plurality of sensors connected to a vehicle, where at least one of the plurality of sensors is positioned on an undercarriage of the vehicle. The plurality of sensors can detect variations in a road on which the vehicle is traveling. The plurality of sensors can also generate information corresponding to the variations of the road. The plurality of sensors can also transmit the information corresponding to the variations in the road to the processing circuit. The information collected by the plurality of sensors may then be used to augment a driving capability of the vehicle.

Abstract: A method for shaping keratin fibres comprising: providing a crosslinking composition, wherein the crosslinking composition comprises: an active agent, wherein the active agent is selected from the group consisting of: oxoethanoic acid, 2,2-dihydroxyethanoic acid, 2,2?-oxybis(2-hydroxy)-ethanoic acid, a derivative thereof, and mixtures thereof; and wherein the active agent has a molecular weight of 500 g/mol or less; a photocatalyst; a cosmetically acceptable carrier; and applying the crosslinking composition to keratin fibres, mechanically shaping the keratin fibres with an appliance or implement, and exposing the composition to electromagnetic radiation having a wavelength of from about 300 nm to about 750 nm. Also a related composition, use, kit and process.

Abstract: The present invention provides a method of preparing D-psicose comprising the steps of (i) providing a mixture of D-psicose and D-fructose; and (ii) contacting the mixture of D-psicose and D-fructose with a probiotic microorganism that is capable of metabolizing D-fructose but not D-psicose and capable of converting D-fructose into L-lactic acid and subjecting the microorganism to culture conditions that allow fermentative removal of D-fructose from the mixture of D-psicose and D-fructose with concomitant production of L-lactic acid. Further provided are uses of a probiotic microorganism that is capable of metabolizing D-fructose but not D-psicose and capable of converting D-fructose into L-lactic acid for fermentative removal of D-fructose from a mixture of D-psicose and D-fructose. In particular, the probiotic microorganism is Lactobacillus rhamnosus GG or Saccharomyces boulardii.

Abstract: A radiation detector (100) includes a photovoltaic layer (102) with first and second opposing sides. The photovoltaic layer is configured to absorb first radiation at the first side and produce electrical charge. The detector further includes a porous silicon quantum dot layer (104) disposed at the second side of the photovoltaic layer and configured to receive second radiation and convert the received second radiation into an electrical signal indicative of an energy level of the received second radiation. The detector further includes an acquisition and communication layer (106) disposed adjacent to the porous silicon quantum dot layer and configured to receive the electrical signal and transmit the electrical signal to a device remote from the radiation detector.

Abstract: An imaging module (114) of an imaging system comprises a porous silicon membrane (116) with a first side (208), a contact side (210) opposite the first side, columns of silicon (212) configured to extend from the first side to the contact side, and columnar holes (214, 502) interlaced with the columns of silicon and configured to extend from the first side to the contact side. The imaging module further includes quantum dots (118) in the columnar holes. The imaging module further includes a metal pad (120) electrically coupled to the columns of silicon of the porous silicon membrane. The quantum dots in the columnar holes are electrically insulated from the metal pad. The imaging module further includes a substrate (122) with an electrically conductive pad (204) in electrical communication with the metal pad that defines a pixel.

Abstract: Embodiments of the invention include methods for producing polymer gels useful in the fabrication of organic cells. The method includes mixing poly(3-hexylthiophene) with phenyl-C61 butyric acid methyl ester and solvent to form a first solution, where the poly(3-hexylthiophene) includes at least some regioregular poly(3-hexylthiophene). The first solution is then cooled to a specified temperature to induce gelation to form an at least partially gelled solution that can be deposited onto a surface to form a coated surface. At least one or more steps of the method can occur as an extrusion process carried out in a twin-screw or single-screw extruder.

Abstract: Among other things, we describe techniques for implementing a vehicle response to sensor failure. In general, one innovative aspect of the subject matter described in this specification can be embodied in methods that include receiving information from a plurality of sensors coupled to a vehicle, determining that a level of confidence of the received information from at least one sensor of a first subset of sensors of the plurality of sensors is less than a first threshold, comparing a number of sensors in the first subset of sensors to a second threshold, and adjusting the driving capability of the vehicle to rely on information received from a second subset of sensors of the plurality of sensors, wherein the second subset of sensors excludes the at least one sensor of the first subset of sensors.