Abstract: Methods for treating breast cancer, specifically cancers resistant to treatment with one or more known breast cancer treatment drugs, and related patient selection strategies for predicting patient response to drug therapy, such strategies including detecting the presence or absence in a patient of one or more of PIK3CA gene amplification, a mutation in PIK3CA, and a decrease in PTEN protein expression, and treating a patient positive for the presence of one or more of same by administering to the subject a pan-ErbB tyrosine kinase inhibitor.

Abstract: An active vibration control system for an aircraft includes a gearbox operably coupling a power source and a component rotatable about an axis. The gearbox includes a flexible region which allows flexure between a first stage and a second stage. At least one active vibration control actuator is arranged in vibrational communication with the flexible region to counteract vibrations transmitted between the power source and the rotatable component.

Abstract: In certain embodiments, the present invention provides methods and compositions to measure unbiasedly the immune health status of an individual or population. A number of measures, including Shannon's entropy, can provide a measure of the diversity and disorder in the population of antibodies in a subject. The measure can be established by reacting the population of antibodies in a subject's blood with a complex surface, such as a peptide array.

Abstract: The present invention provides methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.

Abstract: A rotor hub assembly includes an open rotor hub assembly with an open rotor hub and a mounting plate. The open rotor hub includes an annular base portion with periphery and a plurality of rotary member portions arranged about the annular base portion that each define an aperture for receiving a rotor blade. The mounting plate spans the annular base portion and is coupled to the annular base portion by a resilient member to accommodate radially expansion and contraction of the annular base portion according to loads exerted on the rotor hub by rotor blades seated in the apertures of the rotary member portions.

Abstract: Provided herein are compounds and compositions having antibiotic activity against methicillin resistant Staphylococcus aureus (MRSA). In particular, provided herein is a synbody that bactericidal against multiple strains of MRSA and that can be used in conjugation with currently approved ?-lactam antibiotics to treat MRSA strains having resistance to ?-lactam treatment. Also provided are methods of using the compounds and compositions for treating, preventing or reducing MRSA infections.

Abstract: Methods for diagnosing and characterizing lymphoma, as well as evaluating the disease-free interval following treatment, utilizing patient antibodies bound to peptide microarrays in comparison to an immunosignature characteristic of a lymphoma state or a non-lymphoma state. Characterization includes subtyping of lymphoma utilizing an immunosignature characteristic of a B-cell or T-cell lymphoma.

Abstract: Provided herein are methods for processing biopolymeric arrays, where conditions suitable for forming complexes of immobilized biopolymers (e.g., peptides) and target molecules of a sample can be varied independently of conditions suitable for detecting such complexes using a secondary detection reagent.

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.

Abstract: Composition of synbodies that bind influenza. The synbodies are composed of two peptides joined on a scaffold.

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.

Abstract: Methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.

Abstract: Synbodies specific for Norovirus and coupled with a substrate provide Norovirus binding and detection platforms (FIG. 1). A Norovirus capturing platform, comprising one or more synbodies selected from the group consisting of synbodies 6-6, 92-92, 93-93, and 94-94 coupled to a substrate, has been found to found to bind with either GII.4 Minerva or both GII.4 Minerva and GII.4 Sydney# strains of norovirus.

Abstract: Improved peptide compositions and synbody compositions are disclosed that show improved stability and antibiotic activity. The new antibacterial peptides for S. aureus have particular D-amino acid substitutions in order to increase protease stability while also preserving marked antibiotic activity. Thus, compositions and methods for treating infections related to S. aureus also are disclosed.

Abstract: Provided herein are compounds and compositions having antibiotic activity against methicillin resistant Staphylococcus aureus (MRSA). In particular, provided herein is a synbody that bactericidal against multiple strains of MRSA and that can be used in conjugation with currently approved ?-lactam antibiotics to treat MRSA strains having resistance to ?-lactam treatment. Also provided are methods of using the compounds and compositions for treating, preventing or reducing MRSA infections.

Abstract: The systems, methods, devices, and non-transitory media of the various embodiments provide query independent data identification. In various embodiments, query independent data identification may be used to facilitate data reuse. Query independent data identification may be accomplished using an algebraic expression hash (AEH) function to identify data in a graph or table for reuse based on its origin and what has been done to the data. Use of an AEH function may support a top down approach for identification of data reuse and may also facilitate faster searches using an AEH value. For example, a hash-based search of a universe of data sets may facilitate a top down approach to locate the maximal reuse first (as opposed to the last) and may be less sensitive to the size of the universe.

Abstract: Systems, methods, devices, and non-transitory media of the various embodiments enable the query execution graph for insertions, deletions, and streaming queries to be manipulated to maximize a portion of the query execution that is independent of data changes.

Abstract: Modular or temporary healthcare building units are provided that interconnect with a patient's home. In one embodiment, one of the modular or temporary units includes a fully-equipped ADA-compliant bathroom. In another embodiment, the modular or temporary unit is referred to as a flex unit and typically accommodates a hospital bed and other associated support structures and features for housing and accommodating a patient that is in a stage of recovery or rehabilitation or, in some cases, the flex unit is used for end-of-life care.