Patents by Inventor Stephen Albert Johnston

Stephen Albert Johnston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Linear and circular expression elements
    Patent number: 7018833
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: March 28, 2006
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Method of screening for a biological response using linear and circular expression elements
    Patent number: 6900018
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: May 31, 2005
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Open reading frame detection compositions and methods
    Publication number: 20030166266
    Abstract: The present invention relates to a series of plasmid-based expression vectors and methods for systematically screening entire genomes for gene-coding fragments. The compositions and methods described herein facilitate the detection of open reading frames within a DNA sequence. In this manner, the ORF selection vectors of the invention may be utilized in the isolation of genetic vaccine candidates for expression library immunization.
    Type: Application
    Filed: December 1, 2000
    Publication date: September 4, 2003
    Inventors: Irene Teresa Rombel, Kathryn F. Sykes, Stephen Albert Johnston
  • Linear and circular expression elements
    Publication number: 20030138784
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Application
    Filed: February 15, 2002
    Publication date: July 24, 2003
    Applicant: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Inducible vaccines
    Publication number: 20030039657
    Abstract: The present invention relates to methods of immunization by introducing DNA expression systems into a vertebrate species. Such DNA expression systems preferably include DNA sequences encoding polypeptides of pathogens and antigens and an additional DNA sequence encoding a regulatory moiety which can bind with an administered activating agent to induce expression of an immune response. The present invention also relates to methods of administration of DNA expression systems into the species. The methods of this invention are useful for prophylactic vaccination or therapeutic immunization against infectious disease causing pathogens and other tumor/cancer antigens.
    Type: Application
    Filed: April 14, 2000
    Publication date: February 27, 2003
    Inventors: Stephen Albert Johnston, Baoxi Qu
  • Linear and circular expression elements
    Publication number: 20020160402
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Application
    Filed: February 15, 2002
    Publication date: October 31, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Linear and circular expression elements
    Publication number: 20020155508
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Application
    Filed: February 15, 2002
    Publication date: October 24, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Linear and circular expression elements
    Publication number: 20020150940
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Application
    Filed: February 15, 2002
    Publication date: October 17, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Linear and circular expression elements
    Publication number: 20020146733
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Application
    Filed: February 15, 2002
    Publication date: October 10, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston
  • Methods of screening open reading frames to determine whether they encode polypeptides with an ability to generate an immune response
    Patent number: 6410241
    Abstract: The present invention relates to linear expression elements (LEEs) and circular expression elements (CEEs), which are useful in a variety of molecular biology protocols. Specifically, the invention relates to the use of LEEs and CEEs to screen for gene function, biological effects of gene function, antigens, and promoter function. The invention also provides methods of producing proteins, antibodies, antigens, and vaccines. Also, the invention relates to methods of making LEEs and CEEs, and LEEs and CEEs produced by such methods.
    Type: Grant
    Filed: March 24, 2000
    Date of Patent: June 25, 2002
    Assignee: Board of Regents, The University of Texas System
    Inventors: Kathryn F. Sykes, Stephen Albert Johnston