Abstract: A laparoscopic surgical instrument configured to be ergonomic and anthropometrically correct, the laparoscopic surgical instrument comprising: (a) an ergonomic handle configured to orient a hand of a surgeon in a functional position, the handle comprising a handle grip; (b) an actuating mechanism actuatable by a finger and supported by the handle, the actuating mechanism comprising an actuator shaft and a gearing assembly operable to displace the actuator shaft with a mechanical advantage upon actuation of a trigger by the surgeon; (c) a locking mechanism configured to lock the actuating mechanism in one of a plurality of positions, the locking mechanism comprising a release located in an anthropometrically correct position; and (d) a working shaft having a proximal end coupled to and operable with the actuator shaft, the working shaft having an elongate configuration and a distal working end configured to couple a surgical tool to be manipulated by the surgeon via the handle and the actuating mechanism to pe

Abstract: A laparoscopic surgical instrument configured to be ergonomic and anthropometrically correct, comprising: a) an ergonomic handle configured to orient a hand of a surgeon in a functional position, the handle comprising a wall structure defining an interior portion, and adapted to contain at least a portion of one or more working mechanisms; b) an actuating mechanism actuatable by the surgeon and supported within the interior portion of the handle; c) a working shaft having a proximal end coupled to and operable with the actuating mechanism, the working shaft having an elongate configuration and a distal working end configured to couple a surgical tool to be manipulated by the surgeon; and d) means for accessing the interior portion of the handle to expose an inner side of the wall structure and at least a portion of each of the working mechanisms for cleaning, sterilization and maintenance purposes.

Abstract: Compositions for topical application of erythromycin and derivatives or erythromycin comprising ethanol, isopropyl myristate, glycerol monooleate and the erythromycin compounds are especially useful as a treatment for acne.