Patents by Inventor Stephen B. Ruddy

Stephen B. Ruddy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FORMULATIONS FOR THERAPEUTIC AGENTS ABSORBED THROUGH MUCOUS MEMBRANES
    Publication number: 20010006617
    Abstract: Particulate crystalline therapeutic substances are formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the mucosal membranes to provide extended therapeutic effect.
    Type: Application
    Filed: March 11, 1997
    Publication date: July 5, 2001
    Inventors: GARY G. LIVERSIDGE, W. MARK EICKHOFF, KATHLEEN J. ILLIG, PRAMOD SARPOTDAR, STEPHEN B. RUDDY
  • Methods of treating mammals using nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors
    Patent number: 6221400
    Abstract: The present invention describes formulations of nanoparticulate HIV protease inhibitors comprising a cellulosic surface stabilizer. The nanoparticulate formulations have an increased rate of dissolution in vitro, an increased rate of absorption in vivo, a decreased fed/fasted ratio variability, and a decreased variability in absorption. The present invention is also directed to methods of making the novel formulations. In particular, nanoparticulate formulations of HIV type 1 (HIV-1) and type 2 (HIV-2) protease inhibitors are described.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: April 24, 2001
    Assignee: Elan Pharma International Limited
    Inventors: Gary G. Liversidge, David A. Engers, Mary E. Roberts, Stephen B. Ruddy, Sui-Ming Wong, Shuqian Xu
  • Methods of making nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers
    Patent number: 6068858
    Abstract: The present invention describes formulations of nanoparticulate HIV protease inhibitors comprising a cellulosic surface stabilizer. The nanoparticulate formulations have an increased rate of dissolution in vitro, an increased rate of absorption in vivo, a decreased fed/fasted ratio variability, and a decreased variability in absorption. The present invention is also directed to methods of making the novel formulations. In particular, nanoparticulate formulations of HIV type 1 (HIV-1) and type 2 (HV-2) protease inhibitors are described.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: May 30, 2000
    Assignee: Elan Pharma International Limited
    Inventors: Gary G. Liversidge, David A. Engers, Mary E. Roberts, Stephen B. Ruddy, Sui-Ming Wong, Shuqian Xu
  • Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers
    Patent number: 6045829
    Abstract: The present invention describes formulations of nanoparticulate HIV protease inhibitors comprising a cellulosic surface stabilizer. The nanoparticulate formulations have an increased rate of dissolution in vitro, an increase rate of absorption in vivo, a decreased fed/fasted ratio variability, and a decreased variability in absorption. The present invention is also directed to methods of making the novel formulations. In particular, nanoparticulate formulations of HIV type 1 (HIV-1) and type 2 (HIV-2) protease inhibitors are described.
    Type: Grant
    Filed: July 9, 1997
    Date of Patent: April 4, 2000
    Assignee: Elan Pharma International Limited
    Inventors: Gary G. Liversidge, David A. Engers, Mary E. Roberts, Stephen B. Ruddy, Sui-Ming Wong, Shuqian Xu
  • Nanoparticles containing the R(-)enantiomer of ibuprofen
    Patent number: 5718919
    Abstract: There is described a composition comprised of nanoparticles of a therapeutic agent having a surface modifier adsorbed on the surface thereof. The present composition is characterized in that the therapeutic agent is ibuprofen or fenoprofen which is substantially enriched in the R(-) enantiomer.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: February 17, 1998
    Assignee: NanoSystems L.L.C.
    Inventors: Stephen B. Ruddy, Mary E. Roberts
  • Formulations of oral gastrointestinal diagnostic x-ray contrast agents and oral gastrointestinal therapeutic agents
    Patent number: 5628981
    Abstract: Nanoparticulate crystalline x-ray contrast agents are formulated with stabilizers to enhance contact between the crystalline x-ray contrast agents and the gastrointestinal tract.Nanoparticulate crystalline therapeutic substances also formulated with stabilizers to enhance contact between the crystalline therapeutic substances and the gastrointestinal tract and to provide extended therapeutic effect.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: May 13, 1997
    Assignee: Nano Systems L.L.C.
    Inventors: Gary Liversidge, W. Mark Eickhoff, Kathleen J. Illig, Pramod Sarpotdar, Stephen B. Ruddy
  • Barium salt formulations stabilized by non-ionic and anionic stabilizers
    Patent number: 5593657
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising nanoparticles of a barium salt having associated with its surface non-ionic and anionic stabilizers; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: February 9, 1995
    Date of Patent: January 14, 1997
    Assignee: NanoSystems L.L.C.
    Inventors: Stephen B. Ruddy, W. Mark Eickhoff, Gary Liversidge, Mary E. Roberts
  • Formulations of oral gastrointestinal therapeutic agents in combination with pharmaceutically acceptable clays
    Patent number: 5585108
    Abstract: Nanoparticulate crystalline therapeutic substances formulated with stabilizers and pharmaceutically acceptable clays to enhance contact between the crystalline therapeutic substances and the gastrointestinal tract and to provide extended therapeutic effect.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: December 17, 1996
    Assignee: Nanosystems L.L.C.
    Inventors: Stephen B. Ruddy, W. Mark Eickhoff, Gary Liversidge, Eugene R. Cooper
  • Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers
    Patent number: 5580579
    Abstract: Nanoparticulate crystalline therapeutic or diagnostic substances formulated with stabilizers and high molecular weight, linear poly(ethylene oxide) polymers, enhance contact between the crystalline therapeutic or diagnostic substances and the gastrointestinal tract providing site-specific and extended therapeutic or diagnostic effect.
    Type: Grant
    Filed: February 15, 1995
    Date of Patent: December 3, 1996
    Assignee: Nano Systems L.L.C.
    Inventors: Stephen B. Ruddy, W. Mark Eickhoff, Gary Liversidge
  • Compositions of iodophenoxy alkanes and iodophenyl ethers and pharmaceutically acceptable clays for visualization of the gastrointestinal tract
    Patent number: 5531979
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkanes and iodophenyl ethers as the x-ray producing agents in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: May 23, 1994
    Date of Patent: July 2, 1996
    Assignee: Sterling Winthrop Inc.
    Inventors: Stephen B. Ruddy, Mary E. Roberts, Gregory L. McIntire, Eugene R. Cooper, Edward R. Bacon
  • Isolation of ultra small particles
    Patent number: 5503723
    Abstract: The present invention is a method and apparatus for further reducing the size of nanoparticles. Nanoparticles are defined as having an effective average particle size of less than about 400 nm. The present invention separates the nanoparticles further using electric fields.
    Type: Grant
    Filed: February 8, 1995
    Date of Patent: April 2, 1996
    Assignee: Eastman Kodak Company
    Inventors: Stephen B. Ruddy, W. Mark Eickhoff
  • Compositions of iodophenoxy alkylene ethers and pharmaceutically acceptable clays for visualization of the gastrointestinal tract
    Patent number: 5492687
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkylene ethers and pharmaceutically acceptable clays in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: May 3, 1994
    Date of Patent: February 20, 1996
    Assignee: Sterling Winthrop Inc.
    Inventors: Stephen B. Ruddy, Gregory L. McIntire, Mary E. Roberts, Edward R. Bacon
  • Compositions of iodobenzoic acid derivatives and pharmaceutically acceptable clays for visualization of the gastrointestinal tract
    Patent number: 5484585
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodobenzoic acid derivatives as the x-ray producing agents in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: January 16, 1996
    Assignee: Sterling-Winthrop Inc.
    Inventors: Stephen B. Ruddy, Gregory L. McIntire, Mary E. Roberts, Brent D. Douty, Eugene R. Cooper
  • X-ray contrast compositions containing iodophenoxyalkanes and pharmaceutically acceptable clays
    Patent number: 5476646
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a nonionic x-ray producing agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: December 19, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Stephen B. Ruddy, Gregory L. McIntire, Mary E. Roberts, John L. Toner
  • Compositions of iodophenyl esters and iodophenyl sulfonates and pharmaceutically acceptable clays for visualization of the gastrointestinal tract
    Patent number: 5472682
    Abstract: Disclosed are x-ray contrast compositions of the formula ##STR1## wherein X is ##STR2## or --SO.sub.2 --; Z is H, halo, methyl, ethyl, n-propyl, C.sub.4 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R is C.sub.1 -C.sub.25 alkyl, cycloalkyl or aryl each of which may be optionally substituted with halo, fluoro-lower-alkyl, lower-alkoxy, hydroxy, carboxy or lower-alkoxy carbonyl; lower-alkenyl, lower-alkynyl, lower-alkylene or lower-alkoxy-carbonyloxy;n is 1-5;y is 0-4; andw is 1-4;in combination with a pharmaceutically acceptable clay; and method for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: May 26, 1994
    Date of Patent: December 5, 1995
    Assignee: Sterling Winthrop Inc.
    Inventors: Stephen B. Ruddy, Mary E. Roberts, Gregory L. McIntire, Eugene R. Cooper, Kimberly G. Estep
  • Formulations of oral gastrointestinal diagnostic X-ray contrast agents in combination with pharmaceutically acceptable clays
    Patent number: 5466440
    Abstract: Nanoparticulate crystalline substances formulated with stabilizers and pharmaceutically acceptable clays to enhance contact between the crystalline substances and the gastrointestinal tract. These formulations have improved safety profiles, a low potential for absorption, are not viscous and are not contraindicated for GI perforations or intestinal obstructions. The properties of the surfactant stabilizers are independent of the crystalline drug used and largely determine the extent to which the formulation coats the GI tract.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: November 14, 1995
    Assignee: Eastman Kodak Company
    Inventors: Stephen B. Ruddy, W. Mark Eickhoff, Gary Liversidge, Eugene R. Cooper
  • X-ray contrast compositions containing iodoaniline derivatives and pharmaceutically acceptable clays
    Patent number: 5424056
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising an iodoaniline derivative as the x-ray producing agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: June 13, 1995
    Assignee: Sterling Wintrhop Inc.
    Inventors: Stephen B. Ruddy, Gregory L. McIntire, Mary E. Roberts, Thomas J. Caulifield, Eugene R. Cooper
  • X-ray contrast compositions containing an organic crystalline X-ray contrast agent in combination with pharmaceutically acceptable clays
    Patent number: 5360604
    Abstract: Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a crystalline organic constrast agent in combination with a pharmaceutically acceptable clay in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
    Type: Grant
    Filed: May 23, 1994
    Date of Patent: November 1, 1994
    Assignee: Sterling Winthrop Inc.
    Inventors: Stephen B. Ruddy, Mary E. Roberts, Gregory L. McIntire, Eugene R. Cooper, Carl R. Illig