Abstract: Computer implemented methods (600) based on artificial neural networks for determining the datacube are also disclosed.

Abstract: A spectrally shearing optical relay system, said relay system being comprised of two halves disposed symmetrically about an aperture stop S, wherein each half comprises a plurality of rotationally symmetric optical elements forming an objective and a com-pound prism comprised of a plurality of dispersing prisms. The compound prisms are located between the objectives and the aperture stop. An imaging device with such an optical relay system is also proposed.

Abstract: The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications. In particular, the present disclosure provides materials and methods for expressing concatenated epitopes using a cell-free protein synthesis platform for high throughput, large scale, and unbiased epitope screening and the generation of multi-epitope vaccines.

Abstract: The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications. In particular, the present disclosure provides materials and methods for expressing concatenated epitopes using a cell-free protein synthesis platform for high throughput, large scale, and unbiased epitope screening and the generation of multi-epitope vaccines.

Abstract: A spectrally shearing optical relay system, said relay system being comprised of two halves disposed symmetrically about an aperture stop S, wherein each half comprises a plurality of rotationally symmetric optical elements forming an objective and a com-pound prism comprised of a plurality of dispersing prisms. The compound prisms are located between the objectives and the aperture stop. An imaging device with such an optical relay system is also proposed.

Abstract: The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications. In particular, the present disclosure provides materials and methods for expressing concatenated epitopes using a cell-free protein synthesis platform for high throughput, large scale, and unbiased epitope screening and the generation of multi-epitope vaccines.

Abstract: Systems and methods are provided to specify a location of a planned event via a selection of a listing that has location information. For example, in response to a search request a listing may show a business entity at a geographic location; and the user may select the listing as a way to specify the location of a new event or an existing event. In some embodiments, one event can have multiple listings specifying multiple locations.

Abstract: Systems and methods are provided to specify a location of a planned event via a selection of a listing that has location information. For example, in response to a search request a listing may show a business entity at a geographic location; and the user may select the listing as a way to specify the location of a new event or an existing event. In some embodiments, one event can have multiple listings specifying multiple locations.

Abstract: Systems and methods are provided to specify a location, of a planned event via a selection of a listing that: has location information. For example, in response to a search request a listing may show a business entity at a geographic location; and the user may select the listing as a way to specify the location of a new event or an existing event. In some embodiments, one event can have multiple listings specifying multiple locations.

Abstract: Systems and methods are provided to specify a location of a planned event via a selection of a listing that has location information. For example, in response to a search request a listing may show a business entity at a geographic location; and the user may select the listing as a way to specify the location of a new event or an existing event. In some embodiments, one event can have multiple listings specifying multiple locations.

Abstract: Systems and methods are provided to specify a location of a planned event via a selection of a listing that has location information. For example, in response to a search request a listing may show a business entity at a geographic location; and the user may select the listing as a way to specify the location of a new event or an existing event. In some embodiments, one event can have multiple listings specifying multiple locations.

Abstract: Systems and methods are provided to specify a location of a planned event via a selection of a listing that has location information. For example, in response to a search request a listing may show a business entity at a geographic location; and the user may select the listing as a way to specify the location of a new event or an existing event. In some embodiments, one event can have multiple listings specifying multiple locations.

Abstract: Described herein are rules to modify natural mRNAs or to engineer synthetic mRNAs to increase their translation efficiencies. These rules describe modifications to mRNA coding and 3? UTR sequences intended to enhance protein synthesis by: 1) decreasing ribosomal diversion via AUG or non-canonical initiation codons in coding sequences, and/or 2) by evading miRNA-mediated down-regulation by eliminating one or more miRNA binding sites in coding sequences.

Abstract: Described herein are rules to modify natural mRNAs or to engineer synthetic mRNAs to increase their translation efficiencies. These rules describe modifications to mRNA coding and 3? UTR sequences intended to enhance protein synthesis by: 1) decreasing ribosomal diversion via AUG or non-canonical initiation codons in coding sequences, and/or 2) by evading miRNA-mediated down-regulation by eliminating one or more miRNA binding sites in coding sequences.

Abstract: Systems and methods are provided to deliver business information to users through users' online address books. Data aggregation servers associate individual businesses with one or more unique identifiers. The data aggregation servers collect, store and periodically update business information relating to individual businesses from a variety of sources, such as the businesses themselves and third party sources, such as online publications and message boards. The data aggregation servers store the information in association with the unique identifier. Electronic address book applications hosted on user devices store address book entries for individual businesses in local address book databases. The entries for each business include the unique identifier, and the online address book applications use the unique identifier to retrieve business information relating to individual businesses from the data aggregation servers.

Abstract: Systems and methods are provided to facilitate the presentation of listings according to levels of user interest in the listings. For example, statistics generated from tracking user interactions with the listings and/or other parameters can be used to measure or estimate a level of current user interest in a listing. Listings in search results can be presented in an order according to the levels of current user interest in the listings.

Abstract: Systems and methods sort location dependent information based on selecting multiple groups of information according to location, ordering the groups based on location, and ordering the information within the groups based on at least one or more other criteria. The size(s) of the areas used to select the groups may be predetermined, or dynamically determined (e.g., based on clustering of information along distance to a location of interest).

Abstract: Systems and methods sort location dependent information based on selecting multiple groups of information according to location, ordering the groups based on location, and ordering the information within the groups based on at least one or more other criteria. The size(s) of the areas used to select the groups may be predetermined, or dynamically determined (e.g., based on clustering of information along distance to a location of interest).

Abstract: Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed “STEAP” (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a “serpentine” manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.

Abstract: Described herein are rules to modify natural mRNAs or to engineer synthetic mRNAs to increase their translation efficiencies. These rules describe modifications to mRNA coding and 3? UTR sequences intended to enhance protein synthesis by: 1) decreasing ribosomal diversion via AUG or non-canonical initiation codons in coding sequences, and/or 2) by evading miRNA-mediated down-regulation by eliminating one or more miRNA binding sites in coding sequences.