Abstract: A valve for an aerosol canister for containing medicaments is disclosed. The valve comprises a valve assembly, a ferrule for holding the valve assembly and a gasket for insertion into the ferrule. The ferrule has at least one ferrule interference surface and the gasket has at least one gasket interference surface, and the contact zone between the ferrule interference surface and the gasket interference surface comprises a plurality of relief portions. Preferably, the ferrule interference surface comprises a plurality of ferrule relief pockets and the gasket interference surface comprises a plurality of gasket relief pockets. Also disclosed is a method of manufacturing a valve for an aerosol canister.

Abstract: A valve for an aerosol canister for containing medicaments is disclosed. The valve comprises a valve assembly, a ferrule for holding the valve assembly and a gasket for insertion into the ferrule. The ferrule has at least one ferrule interference surface and the gasket has at least one gasket interference surface, and the contact zone between the ferrule interference surface and the gasket interference surface comprises a plurality of relief portions. Preferably, the ferrule interference surface comprises a plurality of ferrule relief pockets and the gasket interference surface comprises a plurality of gasket relief pockets. Also disclosed is a method of manufacturing a valve for an aerosol canister.

Abstract: An aerosol metering valve comprising: (a) a valve stem movable between a rest position and a firing position comprising: a body portion comprising a circumferential sealing surface (b) a valve body comprising: a body wall, and an internal chamber defined at least in part by the body wall; and (c) a metering gasket having an inner periphery defining an aperture, being disposed near the most interior end of the internal chamber and being configured to be able to form a transient, substantially fluid-tight face seal against the circumferential sealing surface of the valve stem, where at the rest position of the valve stem, the body portion of the valve stem is located within the internal chamber and as the valve stem is moved from its rest position towards its firing position the circumferential sealing surface of the valve stem contacts the metering gasket to form a face seal thereby closing a metering chamber and thereafter further movement of the valve stem towards its firing position causes the metering gask

Abstract: An aerosol metering valve comprising: (a) a valve stem movable between a rest position and a firing position comprising: a body portion comprising a circumferential sealing surface (b) a valve body comprising: a body wall, and an internal chamber defined at least in part by the body wall; and (c) a metering gasket having an inner periphery defining an aperture, being disposed near the most interior end of the internal chamber and being configured to be able to form a transient, substantially fluid-tight face seal against the circumferential sealing surface of the valve stem, where at the rest position of the valve stem, the body portion of the valve stem is located within the internal chamber and as the valve stem is moved from its rest position towards its firing position the circumferential sealing surface of the valve stem contacts the metering gasket to form a face seal thereby closing a metering chamber and thereafter further movement of the valve stem towards its firing position causes the metering gask

Abstract: A metered dose inhaler containing a medicinal formulation of medicament, HFA 134a and/or HFA227, and being substantially free of ethanol and surfactant, with a metering valve comprising a helical spring, a seal, a seal support and a sliding valve stem, wherein the valve is configured and arranged such that a region of compressive contact is defined where a surface applying force to the seal is substantially flat and extends in an arc through an angle in the range from about 180 to about 360 degrees.