Patents by Inventor Stephen E. Lincoln
Stephen E. Lincoln has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7585466Abstract: Genotypes of a subject may be determined by analyzing a biological sample. Measurements of the intensity of allele specific signals may be obtained and used to generate reaction values. These reaction values may be compared to probability distributions in order to obtain conditional probabilities of genotypes of interest. The genotype of the subject may be determined based on the measures of these conditional probabilities.Type: GrantFiled: July 18, 2000Date of Patent: September 8, 2009Assignee: Beckman Coulter, Inc.Inventors: Stephen E. Lincoln, Michael R. Knapp
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Publication number: 20040166500Abstract: The present invention provides purified secretory polynucleotides (sptm). Also encompassed are the polypeptides (SPTM) encoded by sptm. The invention also provides for the use of sptm, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing sptm for the expression of SPTM. The invention additionally provides for the use of isolated and purified SPTM to induce antibodies and to screen libraries of compounds and the use of anti-SPTM antibodies in diagnostic assays. Also provided are microarrays containing sptm and methods of use.Type: ApplicationFiled: July 15, 2003Publication date: August 26, 2004Inventors: Scott R Panzer, Stephen E Lincoln, Christina M Altus, Gerard E Dufour, Jennifer L Jackson, Anissa L Jones, Tam C Dam, Tommy F Liu, Bernard Harris, Vincent Z Flores, Abel Daffo, Rakesh Marwaha, Alice J Chen, Simon C Chang, Edward H Gerstin Jr, Careyna H Peralta, Marie H David, Samantha A Lewis
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Publication number: 20040142331Abstract: The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce antibodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.Type: ApplicationFiled: August 11, 2003Publication date: July 22, 2004Inventors: Stuart E Jackson, Stephen E Lincoln, Christina M Altus, Gerard E Dufour, Michael S Chalup, Jennier L Jackson, Anissa L Jones, Jimmy Y Yu, Rachel J Wright, Darryl Gietzen, Tommy F Liu, Pierre E Yap, Christopher R Dahl, Monika G Momiyama, Diana L Bradley, Sameer D Rohatgi, Bernard Harris, Ann M Roseberry Lincoln, Edward H Gerstin, Careyna H Peralta, Marie H David, Scott R Panzer, Vincent Z Flores, Abel Daffo, Rakesh Marwaha, Alice J Chen, Simon C Chang, Alan P Au, Rebekah R Inman
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Publication number: 20040115629Abstract: The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also en-compassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing dithp for the expression of DITHP. The invention additionally provides for the use of isolated and purified DITHP to induce antibodies and to screen libraries of compounds and the use of anti-DITHP antibodies in diagnostic assays. Also provided are microarrays containing dithp and methods of use.Type: ApplicationFiled: July 9, 2003Publication date: June 17, 2004Inventors: Scott R Panzer, Stephen E Lincoln, Christina M Altus, Gerard E Dufour, Jennifer L Jackson, Anissa L Jones, Tam C Dam, Tommy Liu, Bernard Harris, Vincent Z Flores, Abel Daffo, Rakesh Marwaha, Alice J Chen, Simon C Chang, Edward H Gerstin, Careyna H Peralta, Marie H David, Samantha A Lewis
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Publication number: 20040058365Abstract: The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce antibodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.Type: ApplicationFiled: July 11, 2003Publication date: March 25, 2004Inventors: Scott R Panzer, Stephen E Lincoln, Christina M Altus, Gerard E Dufour, Jennifer L Jackson, Anissa L Jones, Tam C Dam, Tommy F Liu, Bernard Harris, Vincent Z Flores, Abel Daffo, Rakesh Marwaha, Alice J Chen, Simon C Chang, Edward H Gerstin Jr, Careyna H Peralta, Marie H David, Samantha A Lewis
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Publication number: 20040048253Abstract: The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also encompassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing dithp for the expression of DITHP. The invention additionally provides for the use of isolated and purified DITHP to induce antibodies and to screen libraries of compounds and the use of anti-DITHP antibodies in diagnostic assays. Also provided are microarrays containing dithp and methods of use.Type: ApplicationFiled: June 5, 2003Publication date: March 11, 2004Inventors: Scott R. Panzer, Peter A. Spiro, Steven C. Banville, Purvi Shah, Michael S. Chalup, Simon C Chang, Alice J. Chen, Steven A. D'Sa, Stefan Amshey, Christopher E. Dahl, Tam C. Dam, Susan E. Daniels, Gerard E. Dufour, Vincent Flores, Willy T. Fong, Lila B. Greenawalt, Jennifer L. Jackson, Anissa L. Jones, Tommy F. Liu, Ann M. Roseberry Lincoln, Bruce H. Rosen, Frank D. Russo, Theresa K. Stockdreher, Abel Daffo, Rachel J. Wright, Pierre E. Yap, Jimmy Y. Yu, Diana L. Bradley, Shawn R. Bratcher, Wensheng Chen, Howard J. Cohen, David M. Hodgson, Stephen E. Lincoln, Stuart E. Jackson
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Publication number: 20040024535Abstract: The present invention provides relational database systems for storing biomolecular sequence information together with biological annotations detailing the source of the sequence information, and associated reagent information. The acquisition, storage and access of reagent information associated with databased biomolecular sequence information is a particular advantage of the present invention. Such reagent information identifies genetic information and materials which may be made available to a user of the relational database system of the present invention for further application in research, therapeutic pharmaceutical development or other fields. The reagent information aspect of the present invention is preferably used in conjunction with a biomolecular sequence relational database system.Type: ApplicationFiled: February 4, 2003Publication date: February 5, 2004Applicant: Incyte Pharmaceuticals, Inc.Inventors: Stephen E. Lincoln, Tod M. Klingler, Landes C. Wong, Scott R. Panzer, David M. Hodgson, Laura Y. Ito, Andrew D. Ament, Richard Cathcart, Helen E. Jolley, Ingrid E. Akerblom, Brian M. McKelligon, Mayank K. Thanawala
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Publication number: 20040014087Abstract: The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also encompassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing dithp for the expression of DITHP. The invention additionally provides for the use of isolated and purified DITHP to induce antibodies and to screen libraries of compounds and the use of anti-DITHP antibodies in diagnostic assays. Also provided are microarrays containing dithp and methods of use.Type: ApplicationFiled: February 28, 2003Publication date: January 22, 2004Applicant: Incyte CorporationInventors: David M. Hodgson, Stephen E. Lincoln, Frank D. Russo, Peter A. Albany, Steve C. Banville, Shawn R. Bratcher, Gerard E. Dufour, Howard J. Cohen, Bruce H. Rosen, Michael S. Chalup, Jennifer L. Jackson, Anissa L. Jones, Jimmy Y. Yu, Lila B. Greenawalt, Scott R. Panzer, Ann M. Roseberry Lincoln, Rachel J. Wright, Susan E. Daniels
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Publication number: 20030124569Abstract: The present invention provides purified secretory polynucleotides (sptm). Also encompassed are the polypeptides (SPTM) encoded by sptm. The invention also provides for the use of sptm, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing sptm for the expression of SPTM. The invention additionally provides for the use of isolated and purified SPTM to induce antibodies and to screen libraries of compounds and the use of anti-SPTM antibodies in diagnostic assays. Also provided are microarrays containing sptm and methods of use.Type: ApplicationFiled: August 21, 2002Publication date: July 3, 2003Inventors: Scott R. Panzer, Peter A. Spiro, Steven C. Banville, Purvi Shah, Michael S. Chalup, Simon C. Chang, Alice Chen, Steven D'sa, Stefan Amshey, Christopher R. Dahl, Tam C. Dam, Susan E. Daniels, Gerard E. Dufour, Vincent Flores, Willy T. Fong, Lila B. Greenawalt, Jennifer L. Hillman, Anissa L. Jones, Tommy F. Liu, Ann M. Roseberry, Bruce H. Rosen, Frank D. Russo, Theresa K. Stockdreher, Abel Daffo, Rachel J. Wright, Pierre E. Yap, Jimmy Y. Yu, Diana L. Bradley, Shawn R. Bratcher, Wensheng Chen, Howard J. Cohen, David M. Hodgson, Stephen E. Lincoln
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Patent number: 6553317Abstract: The present invention provides relational database systems for storing biomolecular sequence information together with biological annotations detailing the source of the sequence information, and associated reagent information. The acquisition, storage and access of reagent information associated with databased biomolecular sequence information is a particular advantage of the present invention. Such reagent information identifies genetic information and materials which may be made available to a user of the relational database system of the present invention for further application in research, therapeutic pharmaceutical development or other fields. The reagent information aspect of the present invention is preferably used in conjunction with a biomolecular sequence relational database system.Type: GrantFiled: March 4, 1998Date of Patent: April 22, 2003Assignee: Incyte Pharmaceuticals, Inc.Inventors: Stephen E. Lincoln, Tod M. Klingler, Landes C. Wong, Scott R. Panzer, David M. Hodgson, Laura Y. Ito, Andrew D. Ament, Richard Cathcart, Helen E. Jolley, Ingrid E. Akerblom, Brian M. McKelligon, Mayank K. Thanawala
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Publication number: 20020064792Abstract: The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.Type: ApplicationFiled: September 19, 2001Publication date: May 30, 2002Inventors: Stephen E. Lincoln, Tod M. Klingler, Janice Au-Young, Y. Tom Tang, Richard D. Goold, Ingrid E. Akerblom, Jeffrey J. Seilhamer, Phillip R. Hawkins, Lynn E. Murry, Angelo M. Delegeane, Wendy B. Levine, Jennifer L. Hillman, Surya K. Goli, Christina M. Altus, Olga Bandman, Samuel T. LaBrie, Purvi Shah
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Patent number: 5762876Abstract: A device determines the genotype at selected loci within genetic material obtained from a biological sample. One or more data sets are formed and a set of probability distributions including at least one distribution is established. These distributions associate hypothetical reaction values with corresponding probabilities for each genotype of interest at the same locus or at different loci. The genotype is then determined based on these measures.Type: GrantFiled: December 22, 1994Date of Patent: June 9, 1998Assignee: Molecular Tool, Inc.Inventors: Stephen E. Lincoln, Michael R. Knapp
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Patent number: 4790323Abstract: Estimates of the average velocity and turbulence of blood flow are determined by weighting the instantaneous frequencies of a returning Doppler signal. The weighting can be chosen so that the estimates are optimized. The weighting can be chosen so as to duplicate the algorithm of other ultrasound flow imaging systems.Type: GrantFiled: November 3, 1986Date of Patent: December 13, 1988Assignee: Hewlett-Packard CompanyInventors: Steven C. Leavitt, David Lipschutz, Stephen E. Lincoln, Karl Thiele, Paul A. Magnin