Abstract: The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.

Abstract: The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

Abstract: A method of conserving energy during a heating event wherein a coolant is heated in a cooling system is disclosed. The method includes establishing a first set point temperature for a first point in the cooling system and establishing a second set point temperature lower than the first set point temperature for a second point in the cooling system. Normally, the coolant is maintained at the second set point temperature at the second set point in the cooling system. During the heating event, the second set point temperature is raised to substantially match the first set point temperature to reduce necessary heating of the coolant at the first point.

Abstract: A novel deionization filter for removing ions from a coolant in an electric fuel cell vehicle cooling system is disclosed. The deionization filter includes a filter housing having a coolant inlet port, through which the coolant enters the filter housing; and a coolant outlet port, through which the coolant exits the filter housing. An ion exchange bed having positively-charged and negatively-charged ion exchange resin beads is provided in the filter housing for removing negative and positive ions, respectively, from the coolant. At least one filter assembly is typically provided in the filter housing for filtering particles from the coolant.

Abstract: A method of conserving energy during a heating event wherein a coolant is heated in a cooling system is disclosed. The method includes establishing a first set point temperature for a first point in the cooling system and establishing a second set point temperature lower than the first set point temperature for a second point in the cooling system. Normally, the coolant is maintained at the second set point temperature at the second set point in the cooling system. During the heating event, the second set point temperature is raised to substantially match the first set point temperature to reduce necessary heating of the coolant at the first point.

Abstract: A method of conserving energy during a heating event wherein a coolant is heated in a cooling system is disclosed. The method includes establishing a first set point temperature for a first point in the cooling system and establishing a second set point temperature lower than the first set point temperature for a second point in the cooling system. Normally, the coolant is maintained at the second set point temperature at the second set point in the cooling system. During the heating event, the second set point temperature is raised to substantially match the first set point temperature to reduce necessary heating of the coolant at the first point.

Abstract: A particle filter for a fuel cell coolant is disclosed. The particle filter includes a filter housing having an upstream end for receiving the coolant and a downstream end for discharging the coolant. A filter element is provided in the filter housing. A pressure gauge is operably connected to the upstream end of the filter housing for measuring and indicating a pressure of the coolant corresponding to a degree of blockage of the filter element.

Abstract: A method of conserving energy during a heating event wherein a coolant is heated in a cooling system is disclosed. The method includes establishing a first set point temperature for a first point in the cooling system and establishing a second set point temperature lower than the first set point temperature for a second point in the cooling system. Normally, the coolant is maintained at the second set point temperature at the second set point in the cooling system. During the heating event, the second set point temperature is raised to substantially match the first set point temperature to reduce necessary heating of the coolant at the first point.

Abstract: A particle filter for a fuel cell coolant is disclosed. The particle filter includes a filter housing having an upstream end for receiving the coolant and a downstream end for discharging the coolant. A filter element is provided in the filter housing. A pressure gauge is operably connected to the upstream end of the filter housing for measuring and indicating a pressure of the coolant corresponding to a degree of blockage of the filter element.

Abstract: A novel deionization filter for removing ions from a coolant in an electric fuel cell vehicle cooling system is disclosed. The deionization filter includes a filter housing having a coolant inlet port, through which the coolant enters the filter housing; and a coolant outlet port, through which the coolant exits the filter housing. An ion exchange bed having positively-charged and negatively-charged ion exchange resin beads is provided in the filter housing for removing negative and positive ions, respectively, from the coolant. At least one filter assembly is typically provided in the filter housing for filtering particles from the coolant.