Abstract: Provided herein is a device for altering a tissue in an individual comprising an applicator, a means to drive the applicator, and an abrasive material. The devices can further comprise a control means to monitor a physical property of the tissue. Also, provided herein is a device for ablating skin in an individual. Additionally, methods to use these devices are provided.

Abstract: The present invention provides methods of introducing a substance into a living body by forming a plurality of areas on the stratum corneum of the skin such that each area has an enhanced permeability through to the capillary layer. A single laser beam is generated to irradiate the areas on the skin with subablative laser energy to perforate the skin to specific depths without substantially ablating the skin. The substance is introduced into the body by bringing the substance in contact with the areas of enhanced permeability. The present invention further provides lasers comprising a crystal with a partial matte surface-mirror element in combination with a beam splitter to generate a plurality of laser beams substantially concurrently from the single laser beam or with an acousto-optical modulator to sequentially deflect the single laser beam at a plurality of angles.

Abstract: Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.

Abstract: The present invention provides various methods/systems of optical imaging of subsurface anatomical structures and biomolecules utilizing red and infrared radiant energy. Also provided are various applications of such methods/systems in medical diagnosis and treatment.

Abstract: The present invention provides an improved method of removing fluids, gases or other biomolecules, or delivering a pharmaceutical composition, through the skin of a patient without the use of a sharp or needle. The method includes the step of irradiating the stratum corneum, an applied pharmaceutical or an absorbing material, using a laser. By selection of parameters, the laser irradiates the selected material or tissue to create pressure gradients, plasma, cavitation bubbles, or other forms of tissue ablation or alteration. These methods increase the diffusion of pharmaceuticals into, or fluids, gases or other biomolecules out of, the body. For this invention, a pharmaceutical composition can be applied to the skin before or after laser irradiation.