Patents by Inventor Stephen Grimes

Stephen Grimes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunogens against gonadotropin releasing hormone
    Patent number: 5688506
    Abstract: Immunogenic compositions capable of generating an immune response in mammals against GnRH are disclosed. The immunogenic compositions are effective in methods of treating gonadotropin and gonadal steroid hormone dependent diseases and immunological contraception of mammals.
    Type: Grant
    Filed: January 27, 1994
    Date of Patent: November 18, 1997
    Assignee: Aphton Corp.
    Inventors: Stephen Grimes, Robert Scibienski
  • Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
    Patent number: 5622702
    Abstract: Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: April 22, 1997
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg
  • Methods for the preparation of immunogens against gastrin
    Patent number: 5609870
    Abstract: Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: March 11, 1997
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Immunogenic compositions against gastrin peptides
    Patent number: 5607676
    Abstract: Immunogenic compositions useful for the treatment of ulcers or tumors whose growth is dependent on or stimulated by gastrin hormones are disclosed. The immunogenic compositions induce antibodies in a subject which selectively neutralize the specific hormones. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are disclosed. A method of reversing the inventive treatments by neutralizing the antibodies induced in vivo is also disclosed.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: March 4, 1997
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Stephen Grimes, Richard L. Littenberg
  • Immunogenic compositions against human gastrin 17
    Patent number: 5468494
    Abstract: An improved immunogenic composition against human gastrin 17 comprising the peptide pGlu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Ser-Ser-Pro-Pro-Pro-Pro-Cys (SEQ ID NO.: 1) coupled to an immunogenic carrier and pharmaceutical compositions containing the same.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: November 21, 1995
    Assignee: Aphton Corp.
    Inventors: Philip C. Gevas, Stephen Grimes, Stephen L. Karr, Dov Michaeli, Robert Scibienski
  • Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
    Patent number: 5023077
    Abstract: Immunogenic compositions useful for the treatment or prevention of gastric or duodenal ulcer disease are disclosed. The immunogenic compositions effectively operate by inducing antibodies in a subject which selectively neutralize specific peptide gastric hormones and inhibit the binding of the hormones to physiological receptors thus limiting the secretion of stomach acid. Pharmaceutical compositions comprising effective amounts of the immunogenic compositions and methods of treatment using the compositions are also disclosed.
    Type: Grant
    Filed: January 24, 1989
    Date of Patent: June 11, 1991
    Assignee: Aphton Corporation
    Inventors: Philip C. Gevas, Stephen L. Karr, Jr., Stephen Grimes, Richard L. Littenberg
  • Method for immunization against and treatment of infection by ectoparasites and endoparasites
    Patent number: 4891219
    Abstract: This invention relates to a method for the active or passive immunization of a vertebrate against ectoparasites and endoparasites, and a method of treating a vertebrate host infected by ectoparasites or endoparasites, comprising administering to the vertebrate an immunogen comprising one or more endocrine products of ectoparasites and endoparasites, coupled with an immunogenic carrier, or administering to the vertebrate, monoclonal antibodies capable of binding to the native form of the endocrine product.
    Type: Grant
    Filed: September 14, 1987
    Date of Patent: January 2, 1990
    Assignee: Aphton Corporation
    Inventors: Stephen L. Karr, Jr., Elizer Benjamini, Robert J. Scibienski, Stephen Grimes
  • Method for contraception by immunization against the zona pellucida
    Patent number: 4795634
    Abstract: This invention relates to a method for contraception comprising the active immunization of a female mammal against zona pellucida using a composition comprising an effective amount of anti-idiotypic antibodies formed against anti-zona pellucida antibodies, which anti-idiotypic antibodies express internal images of zona pellucida antigenic determinants capable of eliciting a contraceptive response.
    Type: Grant
    Filed: March 14, 1986
    Date of Patent: January 3, 1989
    Assignee: Aphton Corporation
    Inventors: Stephen Grimes, Elizer Benjamini, Philip Gevas