Abstract: The present disclosure relates to a detection system for detecting a failure in a fluid path of a fluid system, the detection system including: at least one pipe comprising a pipe wall which defines a fluid path for the transfer of fluid and at least one electrically conductive element extending along the at least one pipe and which forms an electrical signal path for a first electrical signal which indicates a state of the at least one pipe; and, an electrical terminal electrically connected to the at least one electrically conductive element so that the first electrical signal is transmitted to the electrical terminal via the electrical signal path.

Abstract: The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide SLLQHLIGL (SEQ ID NO: 1) derived from the germline cancer antigen PRAME. Said TCRs may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native PRAME TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.

Abstract: The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide SLLQHLIGL (SEQ ID NO: 1) derived from the germline cancer antigen PRAME. Said TCRs may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native PRAME TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.

Abstract: The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide SLLQHLIGL (SEQ ID NO: 1) derived from the germline cancer antigen PRAME. Said TCRs may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native PRAME TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.

Abstract: A light system configured for reserving and/or dynamically moving/arranging spaces for participants in a class may include a plurality of cells disposed on a surface, each cell having one or more lights disposed therein. Each light is in communication with a controller configured to control at least one of a color, a pattern, and a brightness of each light. The light system may be configured to allow a participant of the class to reserve a space prior to the class and have the space emit light indicating the space is reserved proximate a start time of the class.

Abstract: The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide SLLQHLIGL (SEQ ID NO: 1) derived from the germline cancer antigen PRAME. Said TCRs may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native PRAME TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.

Abstract: A specific binding molecule which binds to CD3 and comprises a polypeptide having an immunoglobulin VL domain and an immunoglobulin VH domain in which the VL domain comprises Complementarity Determining Regions (CDRs) VLCDR1, VLCDR2 and VLCDR3, and in which the VH domain comprises Complementarity Determining Regions (CDRs) VHCDR1, VHCDR2, VHCDR3, each having a respective amino acid sequence as follows in which (SEQ?ID?NO:?1) VLCDR1?is?QDIRNY VLCDR2?is?YTS (SEQ?ID?NO:?2) VLCDR3?is?QQGNTLPWT (SEQ?ID?NO:?3) VHCDR1?is?GYSFTGYA (SEQ?ID?NO:?4) VHCDR2?is?INPYKGVS (SEQ?ID?NO:?5) VHCDR3?is?ARSGYYGDSDWYFDV or an amino acid sequence at least 70% identical thereto.

Abstract: The present invention relates to T cell receptors (TCRs) that bind the HLA-A*02 restricted peptide SLLQHLIGL (SEQ ID NO: 1) derived from the germline cancer antigen PRAME. Said TCRs may comprise non-natural mutations within the alpha and/or beta variable domains relative to a native PRAME TCR. The TCRs of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.

Abstract: A light system configured for reserving and/or dynamically moving/arranging spaces for participants in a class may include a plurality of cells disposed on a surface, each cell having one or more lights disposed therein. Each light is in communication with a controller configured to control at least one of a color, a pattern, and a brightness of each light. The light system may be configured to allow a participant of the class to reserve a space prior to the class and have the space emit light indicating the space is reserved proximate a start time of the class.

Abstract: A light system configured for reserving and/or dynamically moving/arranging spaces for participants in a class may include a plurality of cells disposed on a surface, each cell having one or more lights disposed therein. Each light is in communication with a controller configured to control at least one of a color, a pattern, and a brightness of each light. The light system may be configured to allow a participant of the class to reserve a space prior to the class and have the space emit light indicating the space is reserved proximate a start time of the class.

Abstract: Systems, methods, and devices for heat management of heating implements for a water pipe.

Abstract: A light system configured for reserving and/or dynamically moving/arranging spaces for participants in a class may include a plurality of cells disposed on a surface, each cell having one or more lights disposed therein. Each light is in communication with a controller configured to control at least one of a color, a pattern, and a brightness of each light. The light system may be configured to allow a participant of the class to reserve a space prior to the class and have the space emit light indicating the space is reserved proximate a start time of the class.

Abstract: Systems, methods, and devices for heat management of heating implements for a water pipe.

Abstract: A multi-chambered water pipe comprising an inner chamber and exterior chamber.

Abstract: A multi-chambered water pipe comprising an inner chamber and exterior chamber.

Abstract: A multi-chambered water pipe comprising an inner chamber and exterior chamber.

Abstract: A multi-chambered water pipe comprising an inner chamber and exterior chamber.

Abstract: A sealed thermal cycle heat transferring device having areas of gross surface modification enabling efficiency enhancement through increased working fluid capacity and reduced conduction resistance while still retaining the net surface footprint. Certain embodiments of the present invention facilitate surface enhancement affecting condensing portions as well as evaporating portions. Thermal transfer performance remains adjustable well beyond conventional heat pipe apparatus by allowance of careful selection of surface enhancing parameters including diameter, depth, shape, amount, area and location of surface enhancement. Additional advantages may include the enhancement of mounting, attachment and enablement of thermally generating, dissipating or regulating components, devices, assemblies and any uses where the present invention may benefit thermal addition, subtraction, regulation and transfer.

Abstract: A method for managing unprotected and protected content in a private network, the method including the steps of: receiving content; retrieving metadata associated with the received content; determining whether the received content is unprotected or protected based on the associated metadata; for unprotected content, allowing the unprotected content to be selectively stored, managed and distributed in the private network based on the associated metadata; for protected content, identifying a content protection system associated with the protected content based on the associated metadata, and performing at least one of: displaying information to a user of the private network facilitating retrieval of one or more hardware/software components required by the associated content protection system; retrieving the one or more required hardware/software components; verifying that the one or more required hardware/software components are present in the private network, before allowing the protected content to be selecti

Abstract: An illuminated safety/work glasses device (202) utilizing light emitting diodes embedded into a one-piece flexible array (101) mounted to the left and right side of the lens (102). The light emitting diodes are positioned to the left and right, and above and below the wearer's eyes and may be powered through use of rechargeable powered earpieces (103 and 111) or remote battery pack (207).