Abstract: Nucleic acid molecules that include a nucleotide sequence encoding a chimeric antigen receptor (CAR) and a nucleotide sequence encoding a protease sensitive scFv, wherein the chimeric antigen receptor comprises: an scFv targeting a tumor antigen, a spacer, a transmembrane domain, a co-stimulatory domain, and a CD3 ? signaling domain; and the protease-sensitive scFv and the scFv target the same tumor antigen are described.

Abstract: Disclosed herein are methods and systems for rapid detection of antibiotic resistance of a microorganism in a sample. A modified recombinant phage is also disclosed which comprises an indicator gene in the late gene region. The specificity of infectious agents allows a specific microorganism to be targeted, and an indicator signal may be amplified to optimize assay sensitivity.

Abstract: A family of chimeric antigen receptors (CARs) containing a CD123 specific scFv was developed to target different epitopes on CD123. In some embodiments, such a CD123 chimeric antigen receptor (CD123CAR) gene includes an anti-CD123 scFv region fused in frame to a modified IgG4 hinge region comprising an S228P substitution, an L235E substitution, and optionally an N297Q substitution; a costimulatory signaling domain; and a T cell receptor (TCR) zeta chain signaling domain. When expressed in healthy donor T cells (CD4/CD8), the CD123CARs redirect T cell specificity and mediated potent effector activity against CD123+ cell lines as well as primary AML patient samples. Further, T cells obtained from patients with active AML can be modified to express CD123CAR genes and are able to lyse autologous AML blasts in vitro. Finally, a single dose of 5.0×106 CAR123 T cells results in significantly delayed leukemic progression in mice.

Abstract: A system has a device for capturing biological data from a subject, a machine-readable code associated with the device, an image capturing apparatus with internet connectivity, an image processing unit to interpret the captured biological data, and an internet-connected data repository for storing the interpreted biological data.

Abstract: A system and method for presenting assigned content to a user on a user's device after validating an association of the user with a recognized article based on a valid spatial relationship between the user and the recognized article and also after verifying rights to access the assigned content by the user. The user device equipped with at least one camera used to determine if the article is properly presented. The device captures images and the system has the ability to determine from the images and any additional spatial information the orientation and/or position parameters of the article to confirm whether the valid spatial relationship exists between the recognized article and the user device. The assigned content presented to the user can be contextual and can range from items such as images, music, videos, games, virtual content, augmented content, coupons (virtual or physical), promotions, special offers and the like.

Abstract: A docking station for removable connection to an enteral feeding pump enables automated flushing of an administration set loaded in the enteral feeding pump. The docking station may have a valve seat configured to receive a switchable flow valve of the administration set, a flush controller, an actuator connected to the flush controller and configured to releasably mate with the switchable flow valve when the switchable flow valve is received by the valve seat, and data communication means by which data signals sent by the enteral feeding pump are inputted to the flush controller of the docking station when the enteral feeding pump is connected to the docking station. In operation, the flush controller may receive a flush command sent by the enteral feeding pump and transmit a control signal to the actuator for switching the switchable flow valve to a flush position in response to the flush command.

Abstract: A system has a measuring device adapted to provide a readout indicating a physiological condition of a subject, a machine readable optical code on or closely proximate the measuring device, an imaging apparatus associated with a specific subject, the imaging apparatus having an Internet connection, an image recognition module adapted to process image features to identify the measuring device, and to process the readout portion of the image to determine the physiological condition, and an internet-connected server coupled to a data repository, the Internet-connected server executing coded instructions on a processor. The physiological measuring device is engaged, providing the readout of the physiological condition of the subject, an image of the measuring device including the readout and the machine-readable optical code is captured by the imaging apparatus, and the image is transmitted to the Internet connected server.

Abstract: A method for predicting energy consumption of a vehicle using a statistical model. The method includes (i) predicting a set of future input vectors for the vehicle at defined time intervals corresponding to a plurality of future points in time based on a subset of a plurality of reference input vectors previously generated at the defined time intervals at a plurality of previous points in time, (ii) predicting a change in the energy level of the vehicle using a processor and the statistical model, and (iii) providing results corresponding to the predicted change in the energy level to an output unit of the vehicle. Each reference input vector comprises a vehicle input vector and a database input vector associated with each point in time of the plurality of previous points in time. The database input vector for each defined time interval may be based on at least one of a plurality of environmental data and information about a road condition.

Abstract: A system and method for identifying whether an article is properly presented and duly owned by or licensed to a user and releasing assigned content to the user upon confirmation of such verifiably owned or licensed article. A manipulated user device equipped with at least one camera is deployed to determine if the article is properly presented. The device captures images and the system has the ability to determine from the images and any additional spatial information the orientation and/or position parameters of the article to confirm whether a valid spatial relationship exists between the article and the user device. Due ownership or license is verified by relying on tokens (e.g., Non-Fungible Tokens) and blockchain transaction records. The assigned content released to the user can be contextual and can range from items such as images, music, videos, games, virtual content, augmented content, coupons (virtual or physical), promotions, special offers and the like.

Abstract: A system for monitoring injuries comprising a plurality of wearable user input devices and a wireless transceiver. Each of the plurality of wearable user input devices may be configured to detect motion patterns of a user. Each of the plurality of wearable user input devices may be configured as performance equipment. The wireless transceiver may be configured to communicate the motion patterns to a user device. The user device may be configured to (i) develop and store reference patterns related to impacts, (ii) compare the detected motion patterns with the reference patterns, (iii) estimate a location and direction of an impact based on the comparison, (iv) accumulate data from the estimated impact with previously suffered impact data, (v) aggregate results based on the accumulated impact data and context information and (vi) generate feedback for the user based on the aggregated results.

Abstract: A power management system includes a sensor interface that receives sensor data samples during operation of a vehicle. A storage device stores the sensor data samples for multiple points in time along a route segment traveled by the vehicle. One or more processors analyze the sensor data samples to detect a historical pattern of the vehicle. The one or more processors determine time efficient operational parameters for the vehicle in response to a destination and an estimated travel time to the destination. The estimated travel time may be based on predicted conditions of the vehicle indicated by the historical pattern. The time efficient operational parameters may be selected to decrease the estimated travel time. At least one of the sensor data samples may include telemetry data.

Abstract: A system has a measuring device adapted to provide a readout indicating a physiological condition of a subject, a machine readable optical code on or closely proximate the measuring device, an imaging apparatus associated with a specific subject, the imaging apparatus having an Internet connection, an image recognition module adapted to process image features to identify the measuring device, and to process the readout portion of the image to determine the physiological condition, and an internet-connected server coupled to a data repository, the Internet-connected server executing coded instructions on a processor. The physiological measuring device is engaged, providing the readout of the physiological condition of the subject, an image of the measuring device including the readout and the machine-readable optical code is captured by the imaging apparatus, and the image is transmitted to the Internet connected server.

Abstract: An apparatus comprising a power source, one or more sensors, a transceiver, and a memory. The power source may be configured to store energy to power the apparatus. The one or more sensors may be configured to receive captured data from one of a plurality of sources. The transceiver may be configured to send and receive data to and from a wireless network. The processor may be configured to execute computer readable instructions. The memory may be configured to store a set of instructions executable by the processor. The instructions may be configured to (A) evaluate an expected power usage budget calculated using a predictive model of future energy consumption and (B) (i) store the captured data in the memory in a first mode and (ii) transmit the captured data to a remote storage device in a second mode. The first mode or the second mode is selected based on characteristics of the captured data received from the sensors.

Abstract: A docking station for removable connection to an enteral feeding pump enables automated flushing of an administration set loaded in the enteral feeding pump. The docking station may have a valve seat configured to receive a switchable flow valve of the administration set, a flush controller, an actuator connected to the flush controller and configured to releasably mate with the switchable flow valve when the switchable flow valve is received by the valve seat, and data communication means by which data signals sent by the enteral feeding pump are inputted to the flush controller of the docking station when the enteral feeding pump is connected to the docking station. In operation, the flush controller may receive a flush command sent by the enteral feeding pump and transmit a control signal to the actuator for switching the switchable flow valve to a flush position in response to the flush command.

Abstract: A system has a measuring device providing a readout of a physiological condition, an imaging apparatus with an Internet connection, an image recognition module executing on the imaging apparatus, the image recognition module adapted to compare images to a library of options, and to process the readout by optical character recognition (OCR), and an internet-connected server coupled to a data repository, the Internet-connected server executing coded instructions on a processor.

Abstract: A system comprising a plurality of self-powered devices and at least one remote device. The plurality of self-powered devices may be configured to perform instructions. The plurality of self-powered devices may be configured to select one of a plurality of modes of operation. The remote device may be configured to store scheduling data. The remote device may be configured to communicate with the self-powered devices. The self-powered devices may select one of the plurality of modes of operation based on the scheduling data.

Abstract: A method of vehicle operation includes, using one or more processors, receiving one or more inputs, from one or more sensors of a first vehicle and/or one or more sources communicatively coupled with the one or more processors, while the vehicle is traveling on a vehicle route. In implementations the one or more inputs are used to determine a distance between the first vehicle and a second vehicle and this distance is used as an input to a power management system to increase an energy efficiency of the first vehicle while traveling on the vehicle route. In implementations the one or more inputs and data regarding regenerative braking of the first vehicle are used to calculate one or more speeds and a power management system applies the one or more calculated speeds to the first vehicle. In implementations a reliability estimate is calculated for the one or more calculated speeds.

Abstract: A method of vehicle operation includes, using one or more processors, receiving one or more inputs from one of one or more sensors of a first vehicle and one or more external sources communicatively coupled with the one or more processors. The one or more processors determine a plurality of optional routes existing between a first location of the first vehicle and a future destination of the first vehicle. Using the one or more inputs, the one or more processors predict a vehicle route by predicting which of the optional routes the first vehicle will take to get from the first location to the future destination.

Abstract: Systems and methods are disclosed for providing context-aware selection and recommendation of applications and services on a mobile device. The selection of the preferred applications is based on the context of the user and the context of the applications. A comparison engine related to a recommendation module performs a similarity computation between context attribute vectors of the user and the applications. Based on the similarity computation, a rank-order is produced that determines in what order the application icons should be presented to the user. A digital wallet is also disclosed that maintains the reward points awarded to the user as crypto/virtual tokens based on the instant principles. Unlike prevailing techniques, the reward points are awarded in a context-aware manner after reconciling the conflicting or contradictory usage habits of the user.

Abstract: An apparatus comprising an interface, a memory and a processor. The interface may be configured to receive sensor data samples during operation of a vehicle. The memory may be configured to store the sensor data samples over a number of points in time. The processor may be configured to analyze the sensor data samples stored in the memory to detect a pattern. The processor may be configured to manage an application of brakes of the vehicle in response to the pattern.