Patents by Inventor Stephen J. Dunn
Stephen J. Dunn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240071593Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.Type: ApplicationFiled: October 24, 2023Publication date: February 29, 2024Inventors: Anna Leigh DAVIS, Scott M. BELLIVEAU, Naresh C. BHAVARAJU, Leif N. BOWMAN, Rita M. CASTILLO, Alexandra Elena CONSTANTIN, Rian W. DRAEGER, Laura J. DUNN, Gary Brian GABLE, Arturo GARCIA, Thomas HALL, Hari HAMPAPURAM, Christopher Robert HANNEMANN, Anna Claire HARLEY-TROCHIMCZYK, Nathaniel David HEINTZMAN, Andrea Jean JACKSON, Lauren Hruby JEPSON, Apurv Ullas KAMATH, Katherine Yerre KOEHLER, Aditya Sagar MANDAPAKA, Samuel Jere MARSH, Gary A. MORRIS, Subrai Girish PAI, Andrew Attila PAL, Nicholas POLYTARIDIS, Philip Thomas PUPA, Eli REIHMAN, Ashley Anne RINDFLEISCH, Sofie Wells SCHUNK, Peter C. SIMPSON, Daniel S. SMITH, Stephen J. VANSLYKE, Matthew T. VOGEL, Tomas C. WALKER, Benjamin Elrod WEST, Atiim Joseph WILEY
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Publication number: 20040097409Abstract: The present invention relates to nucleic acid molecules involved in HIV infection, proteins encoded by such nucleic acid molecules, and protective compounds including such nucleic acid molecules, proteins and inhibitors of products encoded by such nucleic acid molecules. In addition, the invention also relates to methods for identifying additional genetic suppressor elements, cellular genes corresponding to such GSEs, and methods of using such cellular genes and their encoded products in screening assays for selecting additional inhibitors of HIV.Type: ApplicationFiled: July 21, 2003Publication date: May 20, 2004Applicant: Subsidiary No. 3, Inc.Inventors: Tanya A. Holzmayer, Stephen J. Dunn
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Publication number: 20030229043Abstract: The present invention relates to the identification of a number of human genes as cellular targets for the design of therapeutic agents for suppressing human immunodeficiency virus infection. These genes encode products which appear to be necessary for HIV replication, as evidenced by an inhibition of HIV infection in cells in which the expression of these genes is down-regulated. In addition, the invention also relates to methods for identifying additional cellular genes as therapeutic targets for suppressing HIV infection, and methods of using such cellular genes and their encoded products in screening assays for selecting additional inhibitors of HIV.Type: ApplicationFiled: March 24, 2003Publication date: December 11, 2003Applicant: Subsidiary No. 3, Inc.Inventors: Tanya A. Holzmayer, Stephen J. Dunn, Andrew Dayn
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Patent number: 6613506Abstract: The present invention relates to nucleic acid molecules involved in HIV infection, proteins encoded by such nucleic acid molecules, and protective compounds including such nucleic acid molecules, proteins and inhibitors of products encoded by such nucleic acid molecules. In addition, the invention also relates to methods for identifying additional genetic suppressor elements, cellular genes corresponding to such GSEs, and methods of using such cellular genes and their encoded products in screening assays for selecting additional inhibitors of HIV.Type: GrantFiled: November 28, 2000Date of Patent: September 2, 2003Assignee: Subsidiary No. 3, Inc.Inventors: Tanya A. Holzmayer, Stephen J. Dunn
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Publication number: 20030109477Abstract: The present invention relates to the identification of several human genes as cellular targets for the design of therapeutic agents for suppressing human immunodeficiency virus (HIV) infection. These genes encode intracellular products which appear to be necessary for HIV replication, as evidenced by an inhibition of HIV infection in cells in which the expression of these genes is down-regulated. Therefore, inhibitors of these genes and their encoded products may be used as therapeutic agents for the treatment and/or prevention of HIV infection. In addition, the invention also relates to methods for identifying additional cellular genes as therapeutic targets for suppressing HIV infection, and methods of using such cellular genes and their encoded products in screening assays for selecting additional inhibitors of HIV.Type: ApplicationFiled: August 20, 2002Publication date: June 12, 2003Inventors: Tanya A. Holzmayer, Stephen J. Dunn, Andrew Dayn
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Publication number: 20030108909Abstract: The present invention relates to genetic elements that suppress the activities of the human immunodeficiency virus (HIV). In particular, the invention relates to polynucleotides isolated from the HIV-1 genome, methods for isolating and identifying such polynucleotides, and methods for using them for the protection of human cells against HIV infection and/or replication.Type: ApplicationFiled: July 29, 2002Publication date: June 12, 2003Inventors: Tanya A. Holzmayer, Stephen J. Dunn, Suk W. Park, Andrew Dayn
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Publication number: 20030087273Abstract: The invention provides methods for identifying human cellular genes and their encoded products for use as targets in the design of therapeutic agents for inhibiting or suppressing human immunodeficiency virus (HIV) infection. The invention also provides methods for identifying protective compounds including immunizing agents that inhibit HIV infection. The invention further provides compounds for use in the treatment or prevention of HIV.Type: ApplicationFiled: July 1, 2002Publication date: May 8, 2003Inventors: Tanya A. Holzmayer, Andrew Holzmayer, Stephen J. Dunn
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Patent number: 6537972Abstract: The present invention relates to the identification of a number of human genes as cellular targets for the design of therapeutic agents for suppressing human immunodeficiency virus infection. These genes encode products which appear to be necessary for HIV replication, as evidenced by an inhibition of HIV infection in cells in which the expression of these genes is down-regulated. In addition, the invention also relates to methods for identifying additional cellular genes as therapeutic targets for suppressing HIV infection, and methods of using such cellular genes and their encoded products in screening assays for selecting additional inhibitors of HIV.Type: GrantFiled: May 29, 1998Date of Patent: March 25, 2003Assignee: Subsidiary No. 3., Inc.Inventors: Tanya A. Holzmayer, Stephen J. Dunn, Andrew Dayn
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Patent number: 6436634Abstract: The present invention relates to the identification of several human genes as cellular targets for the design of therapeutic agents for suppressing human immunodeficiency virus (HIV) infection. These genes encode intracellular products which appear to be necessary for HIV replication, as evidenced by an inhibition of HIV infection in cells in which the expression of these genes is down-regulated. Therefore, inhibitors of these genes and their encoded products may be used as therapeutic agents for the treatment and/or prevention of HIV infection. In addition, the invention also relates to methods for identifying additional cellular genes as therapeutic targets for suppressing HIV infection, and methods of using such cellular genes and their encoded products in screening assays for selecting additional inhibitors of HIV.Type: GrantFiled: June 5, 2000Date of Patent: August 20, 2002Assignee: Subsidiary No. 3, Inc.Inventors: Tanya A. Holzmayer, Stephen J. Dunn, Andrew Dayn
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Patent number: 6426412Abstract: The development of general approaches for the isolation of efficient antivirals is becoming increasingly important. The genetic suppressor element (GSE) technology is an approach based on the functional expression and selection of efficient genetic inhibitors from random fragment libraries derived from a gene or genome of interest. We have applied this technology to isolate potent genetic inhibitors against the human immunodeficiency virus type 1 (HIV-1) The strategy employed involved the following steps: 1) fragmenting the HIV-1 genome into 100-700 base pair (bp) fragments; 2) inserting the fragments into expression vectors to form an expression library; 3) transferring the expression library into a population of cells (e.g., OM10.1) containing an inducible latent HIV-1 provirus; 4) selecting a subpopulation of cells which contain a subset of the expression library enriched for HIV-1 GSE by monitoring the expression of a cellular (e.g., CD4) or viral (e.g.Type: GrantFiled: December 18, 1996Date of Patent: July 30, 2002Assignee: Subsidiary No. 3, Inc.Inventors: Tanya A. Holzmayer, Stephen J. Dunn, Suk W. Park, Andrew Dayn
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Patent number: 6326152Abstract: The present invention relates to the identification of several human genes as cellular targets for the design of therapeutic agents for suppressing human immunodeficiency virus (HIV) infection. These genes encode intracellular products which appear to be necessary for HIV replication, as evidenced by an inhibition of HIV infection in cells in which the expression of these genes is down-regulated. Therefore, inhibitors of these genes and their encoded products may be used as therapeutic agents for the treatment and/or prevention of HIV infection. In addition, the invention also relates to methods for identifying additional cellular genes as therapeutic targets for suppressing HIV infection, and methods of using such cellular genes and their encoded products in screening assays for selecting additional inhibitors of HIV.Type: GrantFiled: June 5, 2000Date of Patent: December 4, 2001Assignee: Subsidiary No. 3, Inc.Inventors: Tanya A. Holzmayer, Stephen J. Dunn, Andrew Dayn
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Patent number: 6316210Abstract: The present invention relates to genetic elements that suppress the activities of the human immunodeficiency virus (HIV). In particular, the invention relates to polynucleotides isolated from the HIV-1 genome, methods for isolating, identifying and designing such polynucleotides, and methods for using them for the protection of human cells against HIV infection and/or replication. The present invention also relates to polynucleotides that prevent tumor cell formation and the use of such polynucleotides to prevent tumorigenesis.Type: GrantFiled: September 1, 1999Date of Patent: November 13, 2001Assignee: Subsidiary No. 3, Inc.Inventors: Tanya A. Holzmayer, Stephen J. Dunn
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Patent number: 6071743Abstract: The present invention relates to the identification of several human genes as cellular targets for the design of therapeutic agents for suppressing human immunodeficiency virus (HIV) infection. These genes encode intracellular products which appear to be necessary for HIV replication, as evidenced by an inhibition of HIV infection in cells in which the expression of these genes is down-regulated. Therefore, inhibitors of these genes and their encoded products may be used as therapeutic agents for the treatment and/or prevention of HIV infection. In addition, the invention also relates to methods for identifying additional cellular genes as therapeutic targets for suppressing HIV infection, and methods of using such cellular genes and their encoded products in screening assays for selecting additional inhibitors of HIV.Type: GrantFiled: June 2, 1997Date of Patent: June 6, 2000Assignee: Subsidiary No. 3, Inc.Inventors: Tanya A. Holzmayer, Stephen J. Dunn, Andrew Dayn
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Patent number: 5567274Abstract: A method and apparatus supply ozone containing gas under superatmospheric pressure to an ozone delignification device. The speed of a water ring compressor is controlled so that it compresses as much ozone gas per unit time at desired superatmospheric pressure as the ozone delignification unit utilizes, with essentially no excess. The ozone containing gas is fed from the water ring compressor through a separator buffer tank which levels out pressure pulses and separates cooling water from compressed ozone gas prior to the gas entering the ozone delignification unit. The gas passes through a control valve controlled by a mass flowmeter which senses the amount of cellulose pulp fed to the ozone delignification unit. The speed control of the compressor may be provided by a differential pressure controller connected across the control valve.Type: GrantFiled: July 15, 1994Date of Patent: October 22, 1996Assignee: Ahlstrom Machinery Inc.Inventors: Erwin D. Funk, Kaj Henricson, Stephen J. Dunn
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Patent number: 5364505Abstract: A method and apparatus supply ozone containing gas under superatmospheric pressure to an ozone delignification device. The speed of a water ring compressor is controlled so that it compresses as much ozone gas per unit time at desired superatmospheric pressure as the ozone delignification unit utilizes, with essentially no excess. The ozone containing gas is fed from the water ring compressor through a separator buffer tank which levels out pressure pulses and separates cooling water from compressed ozone gas prior to the gas entering the ozone delignification unit. The gas passes through a control valve controlled by a mass flowmeter which senses the amount of cellulose pulp fed to the ozone delignification unit. The speed control of the compressor may be provided by a differential pressure controller connected across the control valve.Type: GrantFiled: December 7, 1992Date of Patent: November 15, 1994Assignee: Kamyr, Inc.Inventors: Erwin D. Funk, Kaj Henricson, Stephen J. Dunn
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Patent number: 5258100Abstract: A method and mixer are provided for mixing chemical (such as a gas like chlorine or oxygen) with a slurry (such as paper pulp having a consistency of about 1-16%) in such a way that separation of gas from the slurry at the discharge from the mixer is avoided. Where the mixer housing has a radial discharge, the leading and trailing walls of the discharge (in the direction of circular and tangential movement of slurry within the main body housing of the mixer) present curved configurations to transition the slurry from circular/tangential movement to radial movement. The curvature of the configurations (which may be provided by inserts) does not exceed an angle of about 10 degrees at any point along them until radial flow is established.Type: GrantFiled: February 28, 1992Date of Patent: November 2, 1993Assignee: Kamyr, Inc.Inventors: Toivo Niskanen, Brian F. Greenwood, Kari Peltonen, Stephen J. Dunn, Mika P. Makela
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Patent number: 4548127Abstract: A piston for an internal combustion engine comprising a piston body (1) and a crown portion (3) that are connected by anchoring means comprising elongate members (7,23,26,79,80) that extend from the crown portion (3) into the piston body (1) so as to transmit tensile and compressive loads from the crown to a portion of the piston body in a region spaced axially away from the crown portion at a temperature which, at maximum operating temperatures, is low enough to prevent loosening of the anchoring means, characterized in that co-operating surfaces of said anchoring means (7,9,16) and piston body (1) are pre-loaded into contact with one another by virtue of mechanically applied strain energy stored in the anchoring means and piston body (1) and which acts axially to prevent parting of said co-operating surfaces by said tensile and compressive loads without being dependent on any reaction forces between the adjacent faces of the crown portion and piston body.Type: GrantFiled: August 3, 1983Date of Patent: October 22, 1985Inventors: Stephen J. Dunn, Alan W. Sparrow
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Patent number: 4140096Abstract: A piston for an internal combustion engine, having a combustion chamber with an overhanging lip formed by resistant metal insert anchored in the piston by means of members extending from the insert and embedded in the piston material. A portion of the free end of each member is located in a cool portion of the piston and mechanically keyed therein and is preferably also metallurgically bonded to the piston material in order to prevent the insert being loosened during service.Type: GrantFiled: March 30, 1977Date of Patent: February 20, 1979Assignee: Perkins Engines LimitedInventors: Stephen J. Dunn, Glyn H. Youdan
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Patent number: 4137887Abstract: A method of manufacturing a piston for an internal combustion engine in which a cast-in insert comprising a combustion chamber lip and a piston ring carrier joined by radial limbs is secured against loosening in service by spraying metal or cermet into a peripheral groove partially in the ring carrier and partially in the piston body a band firmly bonded to the carrier and the body. The carrier may be castellated to interlock with the piston material.Type: GrantFiled: June 6, 1977Date of Patent: February 6, 1979Assignee: Perkins Engines LimitedInventor: Stephen J. Dunn