Abstract: Transport Layer Security (TLS) connection establishment between a client and a server for a new session is enabled using an ephemeral (temporary) key pair. In response to a request, the server generates a temporary certificate by signing an ephemeral public key using the server's private key. A certificate chain comprising at least the temporary certificate that includes the ephemeral public key, together with a server certificate, is output to the client by the server, which acts as a subordinate Certificate Authority. The client validates the certificates, generates a session key and outputs the session key wrapped by the ephemeral public key. To complete the connection establishment, the server applies the ephemeral private key to recover the session key derived at the client for the new session. The client and server thereafter use the session key to encrypt and decrypt data over the link. The ephemeral key pair is not reused.

Abstract: A wearable infusion pump assembly includes a reservoir for receiving an infusible fluid, and an external infusion set configured to deliver the infusible fluid to a user. A fluid delivery system is configured to deliver the infusible fluid from the reservoir to the external infusion set. The fluid delivery system includes a volume sensor assembly, and a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the volume sensor assembly. The volume sensor assembly is configured to determine the volume of at least a portion of the quantity of fluid. The fluid delivery system further includes at least one optical sensor assembly configured to sense the movement of the pump assembly, a first valve assembly configured to selectively isolate the pump assembly from the reservoir, and a second valve assembly configured to selectively isolate the volume sensor assembly from the external infusion set.

Abstract: An optical stack for sensing a presence of an analyte is provided. The optical stack includes a sensor material. The sensor material includes a first optical response including a first optical property having a second value in response to an excitation signal including the first optical property having a first value different from the second value. The first optical response includes a second optical property sensitive to the presence of the analyte. The optical stack includes a first optical film disposed proximate the sensor material and includes a third optical property having respective third and fourth values in response to the respective first and second values of the first optical property. The third value is different from the fourth value by at least a factor of 2.

Abstract: Provided herein are bifunctional compounds that bind tau protein and/or promote targeted ubiquitination for the degradation of tau protein. In particular, provided are compounds that can bind tau protein, a protein whose aggregation is implicated in a variety of neurodegenerative disease (e.g., tauopathies), and can promote its degradation by recruiting an E3 ubiquitin ligase (e.g., Cereblon), which can ubiquitinate tau protein, marking it for proteasomal degradation. Also provided are radiolabeled forms of the bifunctional compounds, pharmaceutical compositions comprising the bifunctional compounds, methods of detecting and/or diagnosing neurological disorders, methods of detecting and/or diagnosing pathological aggregation of tau protein (e.g., in the central nervous system), methods of treating and/or preventing neurological disorders, and methods of promoting the degradation of tau protein by E3 ubiquitin ligase activity in a subject by administering a compound or composition described herein.

Abstract: A syringe pump includes a lead screw, a cam, and a grasper. The grasper assembly has first and second graspers arms each having a first end and a second end. The second ends of the first and second grasper arms are configured to engage with the lead screw. The first ends of the first and second grasper arms are configured to engage with the cam such that actuation of the cam toward the grasper assembly causes the second ends of the first and second grasper arms to pivotally approach each other. The second ends of the first and second grasper arms each includes threads to engage the lead screw when the second ends of the first and second grasper arms approach each other. The plunger head coupled to said grasper assembly and operative to drive a plunger of a syringe into a barrel of said syringe.

Abstract: The present invention is directed towards apparatuses and methods for securing a location. Particularly, the present invention is directed towards methods, apparatuses, and integrated systems for the screening of individual passengers and their corresponding carry-on baggage carts with improved throughput, efficiency, and quality. In addition, the current invention is directed towards a carry-on baggage cart specifically designed for the disclosed integrated carry-on baggage cart and passenger screening system of the present invention.

Abstract: The present invention is directed towards apparatuses and methods for securing a location. Particularly, the present invention is directed towards methods, apparatuses, and integrated systems for the screening of individual passengers and their corresponding carry-on baggage carts with improved throughput, efficiency, and quality. In addition, the current invention is directed towards a carry-on baggage cart specifically designed for the disclosed integrated carry-on baggage cart and passenger screening system of the present invention.

Abstract: The present invention is directed towards apparatuses and methods for securing a location. Particularly, the present invention is directed towards methods, apparatuses, and integrated systems for the screening of individual passengers and their corresponding carry-on baggage carts with improved throughput, efficiency, and quality. In addition, the current invention is directed towards a carry-on baggage cart specifically designed for the disclosed integrated carry-on baggage cart and passenger screening system of the present invention.

Abstract: The present invention is directed toward an integrated security checkpoint that can screen both individual passengers and carry-on carts containing their baggage. The methods, apparatuses, and systems of the present invention enable the efficient scanning of both individual passengers and their respective carry-on carts in the same secure area by providing individual passengers with a novel screening cart, permitting passengers to send the screening cart through an X-ray imaging machine, and permitting passengers to walk through an adjacent metal detector where, once cleared, the individual passenger can retrieve his or her screening cart.

Abstract: The present invention is directed towards apparatuses and methods for securing a location. Particularly, the present invention is directed towards methods, apparatuses, and integrated systems for the screening of individual passengers and their corresponding carry-on baggage carts with improved throughput, efficiency, and quality. In addition, the current invention is directed towards a carry-on baggage cart specifically designed for the disclosed integrated carry-on baggage cart and passenger screening system of the present invention.