Patents by Inventor Stephen J. Kennel
Stephen J. Kennel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10646568Abstract: Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are administered to a subject. Antibodies to the amyloid-reactive peptides are then administered to the subject. Upon administration of the antibodies, the amyloid-reactive peptides bind the antibodies and thus pre-target the antibodies to the amyloid deposits. In other examples, an amyloid-reactive fusion peptide contains an epitope of a known antibody. When the fusion peptide is administered to a subject, the fusion peptide binds amyloids in the subject. Administration to the subject of the known antibody that binds the epitope of the fusion peptide then targets the antibody to the amyloid deposit to which the fusion peptide is bound.Type: GrantFiled: July 16, 2018Date of Patent: May 12, 2020Assignee: UNIVERSITY OF TENESSEE RESEARCH FOUNDATIONInventors: Jonathan S Wall, Stephen J Kennel, James S Foster
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Patent number: 10308685Abstract: Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of heparin-binding peptide. Also disclosed herein are methods for blocking viral binding to a cell. Further disclosed are anti-viral compositions for administration to a subject infected with a virus. Administration of the anti-viral composition inhibits viral infection of the subject.Type: GrantFiled: May 25, 2017Date of Patent: June 4, 2019Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventors: Jonathan S. Wall, Timothy E. Sparer, Stephen J. Kennel
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Publication number: 20190083616Abstract: Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are administered to a subject. Antibodies to the amyloid-reactive peptides are then administered to the subject. Upon administration of the antibodies, the amyloid-reactive peptides bind the antibodies and thus pre-target the antibodies to the amyloid deposits. In other examples, an amyloid-reactive fusion peptide contains an epitope of a known antibody. When the fusion peptide is administered to a subject, the fusion peptide binds amyloids in the subject. Administration to the subject of the known antibody that binds the epitope of the fusion peptide then targets the antibody to the amyloid deposit to which the fusion peptide is bound.Type: ApplicationFiled: July 16, 2018Publication date: March 21, 2019Inventors: Jonathan S. Wall, Stephen J. Kennel, James S. Foster
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Patent number: 10213506Abstract: Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are administered to a subject. Antibodies to the amyloid-reactive peptides are then administered to the subject. Upon administration of the antibodies, the amyloid-reactive peptides bind the antibodies and thus pre-target the antibodies to the amyloid deposits. In other examples, an amyloid-reactive fusion peptide contains an epitope of a known antibody. When the fusion peptide is administered to a subject, the fusion peptide binds amyloids in the subject. Administration to the subject of the known antibody that binds the epitope of the fusion peptide then targets the antibody to the amyloid deposit to which the fusion peptide is bound.Type: GrantFiled: August 24, 2015Date of Patent: February 26, 2019Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventors: Jonathan S. Wall, Stephen J. Kennel, James S. Foster
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Patent number: 10046050Abstract: Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are administered to a subject. Antibodies to the amyloid-reactive peptides are then administered to the subject. Upon administration of the antibodies, the amyloid-reactive peptides bind the antibodies and thus pre-target the antibodies to the amyloid deposits. In other examples, an amyloid-reactive fusion peptide contains an epitope of a known antibody. When the fusion peptide is administered to a subject, the fusion peptide binds amyloids in the subject. Administration to the subject of the known antibody that binds the epitope of the fusion peptide then targets the antibody to the amyloid deposit to which the fusion peptide is bound.Type: GrantFiled: February 24, 2016Date of Patent: August 14, 2018Assignee: UNIVERSITY OF TENESSEE RESEARCH FOUNDATIONInventors: Jonathan S. Wall, Stephen J. Kennel, James S. Foster
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Publication number: 20170281807Abstract: Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are administered to a subject. Antibodies to the amyloid-reactive peptides are then administered to the subject. Upon administration of the antibodies, the amyloid-reactive peptides bind the antibodies and thus pre-target the antibodies to the amyloid deposits. In other examples, an amyloid-reactive fusion peptide contains an epitope of a known antibody. When the fusion peptide is administered to a subject, the fusion peptide binds amyloids in the subject. Administration to the subject of the known antibody that binds the epitope of the fusion peptide then targets the antibody to the amyloid deposit to which the fusion peptide is bound.Type: ApplicationFiled: August 24, 2015Publication date: October 5, 2017Inventors: Jonathan S. WALL, Stephen J. KENNEL, James S. FOSTER
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Publication number: 20170267722Abstract: Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of heparin-binding peptide. Also disclosed herein are methods for blocking viral binding to a cell. Further disclosed are anti-viral compositions for administration to a subject infected with a virus. Administration of the anti-viral composition inhibits viral infection of the subject.Type: ApplicationFiled: May 25, 2017Publication date: September 21, 2017Inventors: Jonathan S. Wall, Timothy E. Sparer, Stephen J. Kennel
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Patent number: 9683017Abstract: Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of heparin-binding peptide. Also disclosed herein are methods for blocking viral binding to a cell. Further disclosed are anti-viral compositions for administration to a subject infected with a virus. Administration of the anti-viral composition inhibits viral infection of the subject.Type: GrantFiled: July 16, 2015Date of Patent: June 20, 2017Assignee: UNIVERSITY TENNESSEE RESEARCH FOUNDATIONInventors: Jonathan S. Wall, Timothy E. Sparer, Stephen J. Kennel
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Publication number: 20160243230Abstract: Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are administered to a subject. Antibodies to the amyloid-reactive peptides are then administered to the subject. Upon administration of the antibodies, the amyloid-reactive peptides bind the antibodies and thus pre-target the antibodies to the amyloid deposits. In other examples, an amyloid-reactive fusion peptide contains an epitope of a known antibody. When the fusion peptide is administered to a subject, the fusion peptide binds amyloids in the subject. Administration to the subject of the known antibody that binds the epitope of the fusion peptide then targets the antibody to the amyloid deposit to which the fusion peptide is bound.Type: ApplicationFiled: February 24, 2016Publication date: August 25, 2016Inventors: Jonathan S. WALL, Stephen J. KENNEL, James S. FOSTER
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Publication number: 20160016999Abstract: Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of heparin-binding peptide. Also disclosed herein are methods for blocking viral binding to a cell. Further disclosed are anti-viral compositions for administration to a subject infected with a virus. Administration of the anti-viral composition inhibits viral infection of the subject.Type: ApplicationFiled: July 16, 2015Publication date: January 21, 2016Inventors: Jonathan S. Wall, Timothy E. Sparer, Stephen J. Kennel
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Patent number: 8808666Abstract: The present invention provides a novel method of detecting amyloids in a subject. The present invention provides peptides that bind selectively to amyloids and are useful for detecting amyloids and diagnosing and/or monitoring the progression of amyloid mediated conditions.Type: GrantFiled: September 26, 2012Date of Patent: August 19, 2014Assignee: University of Tennessee Research FoundationInventors: Jonathan Wall, Stephen J. Kennel
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Patent number: 6289717Abstract: A sensor apparatus is provided using a microcantilevered spring element having a coating of a detector molecule such as an antibody or antigen. A sample containing a target molecule or substrate is provided to the coating. The spring element bends in response to the stress induced by the binding which occurs between the detector and target molecules. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 &mgr;m long, approximately 1 to 50 &mgr;m wide, and approximately 0.3 to 3.0 &mgr;m thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers.Type: GrantFiled: March 30, 1999Date of Patent: September 18, 2001Assignee: U. T. Battelle, LLCInventors: Thomas G. Thundat, K. Bruce Jacobson, Mitchel J. Doktycz, Stephen J. Kennel, Robert J. Warmack
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Patent number: RE47838Abstract: Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of heparin-binding peptide. Also disclosed herein are methods for blocking viral binding to a cell. Further disclosed are anti-viral compositions for administration to a subject infected with a virus. Administration of the anti-viral composition inhibits viral infection of the subject.Type: GrantFiled: January 30, 2018Date of Patent: February 4, 2020Assignee: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATIONInventors: Jonathan S. Wall, Timothy E. Sparer, Stephen J. Kennel