Patents by Inventor Stephen J. Russell
Stephen J. Russell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240141376Abstract: Canine distemper vims (CDV) hemagglutinin (H) and fusion (F) polypeptides are provided herein. For example, engineered configurations of CDV fusogenic membrane glycoprotein (FMG) complexes containing H and F glycoproteins are provided herein, as are pseudotyped viruses (e.g., pseudotyped lentiviruses) containing the engineered CDV FMG complexes on their surface. In addition, this document provides nucleic acid molecules encoding CDV-H and/or CDV-F polypeptide components, methods for making recombinant cells expressing the CDV-H and CDV-F polypeptides, and methods for making and using pseudotyped viruses (e.g., pseudotyped lentiviruses) containing CDV FMG complexes.Type: ApplicationFiled: February 23, 2022Publication date: May 2, 2024Inventors: Stephen J. Russell, Miguel A. Munoz Alia
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Patent number: 11932879Abstract: This document relates to methods and materials for virotherapy. For example, this document provides methods and materials for treating cancer using a recombinant mumps virus as an oncolytic agent.Type: GrantFiled: June 23, 2022Date of Patent: March 19, 2024Assignee: Mayo Foundation for Medical Education and ResearchInventors: Mark J. Federspiel, Arun Ammayappan, Gennett Pike, Stephen James Russell
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Publication number: 20240082330Abstract: This document relates to methods and materials involved in treating cancer. For example, methods and materials for using one or more oncolytic viruses (e.g., one or more replicating oncolytic viruses) to treat cancer in a mammal (e.g., a human) identified as having a cancer likely to respond to oncolytic virotherapy are provided.Type: ApplicationFiled: November 14, 2023Publication date: March 14, 2024Applicant: Mayo Foundation for Medical Education and ResearchInventors: Kah-Whye Peng, Stephen James Russell, Mitesh J. Borad, Yumei Zhou, Amber C. Miller
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Publication number: 20230184765Abstract: The disclosure provides methods for determining the presence of coronavirus neutralizing antibodies in a sample as well as associated compositions and kits. The methods of the disclosure use recombinant vesicular stomatitis virus (VSV) particles, wherein the VSV glycoprotein (G) is replaced by a coronavirus spike (S) glycoprotein or a fragment or a derivative thereof. In a specific embodiment, the S glycoprotein is derived from Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) and the methods are used for determining the presence of SARS-CoV-2 neutralizing antibodies.Type: ApplicationFiled: April 19, 2021Publication date: June 15, 2023Applicant: VYRIAD, INC.Inventors: Stephen J. RUSSELL, Kah Whye PENG, Patrycja LECH, Rianna VANDERGAAST, Timothy CAREY
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Publication number: 20230149536Abstract: The disclosure provides recombinant vesicular stomatitis vims (VSV) particles, wherein the VSV glycoprotein (G) is replaced by a coronavirus spike (S) glycoprotein, or a fragment or a derivative thereof, as well as compositions, vaccines, kits, and methods for using the recombinant VSV particles. In a specific embodiment, the S glycoprotein is derived from Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) and the methods are for the treatment or prevention of a disease or disorder in a subject infected with SARS-CoV-2. In certain embodiments, the disease or disorder is COVID-19.Type: ApplicationFiled: April 19, 2021Publication date: May 18, 2023Inventors: Stephen J. RUSSELL, Kah Whye PENG, Patrycja LECH, Alina BAUM, Christos KYRATSOUS
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Publication number: 20210252143Abstract: The present application is directed to therapeutic regimens and methods of treating cancer, with the regimens and methods comprising administering to the subject a programmed death-ligand 1 (PD-L1) inhibitor and a recombinant vesicular stomatitis virus that has been engineered to expresses interferon beta (VSV-IFN?-NIS).Type: ApplicationFiled: June 21, 2019Publication date: August 19, 2021Inventors: Stephen J. Russell, Alice Bexon, Kah-Whye Peng, Rose Marie Diaz
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Patent number: 7982022Abstract: A novel strategy for monitoring the location of a transgene in a mammal is disclosed. A sodium iodide symporter is genetically fused to either the N-terminus or C-terminus of the product of a transgene through a linker peptide which bears the recognition sequence of a host cell protease. Expression of the transgene confers the activity of the sodium iodide symporter (NIS) to a host cell which expresses the transgene. Subsequent administration of labeled iodine results in transport of the labeled iodine into the cell bearing the NIS, which can then be localized and measured using standard imaging techniques. The system is particularly useful for monitoring the location of therapeutic transgenes and tissue-specific distribution of the therapeutic gene product.Type: GrantFiled: December 15, 2009Date of Patent: July 19, 2011Assignee: Mayo Foundation for Medical Education and ResearchInventors: Stephen J. Russell, John Morris
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Patent number: 7854928Abstract: A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 103 pfus to about 1012 pfus and is delivered by direct injection into a group of cancer cells or via intravenous injection.Type: GrantFiled: January 15, 2010Date of Patent: December 21, 2010Assignee: Mayo Foundation for Medical Education and ResearchInventors: Stephen J. Russell, Adele Kay Fielding, Kah-Whye Peng, Deanna Grote
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Patent number: 7814625Abstract: The invention provides a non-woven fabric comprising at least two separate but interconnected layers, each of the layers being provided with discrete interconnections so as to provide discrete voids between the two layers of fabric.Type: GrantFiled: April 27, 2010Date of Patent: October 19, 2010Assignee: Nonwovens Innovation & Research Institute LimitedInventors: Stephen J. Russell, Alireza Pourmohammadi, Ningtao Mao, Idris A. Ahmed, Manoj K. Rathod
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Publication number: 20100201020Abstract: The invention provides a non-woven fabric comprising at least two separate but interconnected layers, each of the layers being provided with discrete interconnections so as to provide discrete voids between the two layers of fabric.Type: ApplicationFiled: April 27, 2010Publication date: August 12, 2010Applicant: Nonwovens Innovation and Research Institute LimitedInventors: Stephen J. Russell, Alireza Pourmohammadi, Ningtao Mao, Idris A. Ahmed, Manoj K. Rathod
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Patent number: 7718249Abstract: The invention provides a non-woven fabric comprising at least two separate but interconnected layers, each of the layers being provided with discrete interconnections so as to provide discrete voids between the two layers of fabric.Type: GrantFiled: July 9, 2004Date of Patent: May 18, 2010Assignee: Nonwovens Innovation & Research Institute LimitedInventors: Stephen J. Russell, Alireza Pourmohammadi, Ningtao Mao, Idris A. Ahmed, Manoj K. Rathod
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Publication number: 20100111873Abstract: This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal. For example, methods for using infectious nucleic acid to treat cancer, engineered viral nucleic acid, methods for making engineered viral nucleic acid, methods for identifying infectious nucleic acid for treating cancer, methods and materials for controlling virus-mediated cell lysis, and methods and materials for assessing the control of virus-mediated cell lysis are provided.Type: ApplicationFiled: February 20, 2008Publication date: May 6, 2010Inventors: Stephen J. Russell, Elizabeth J. Kelly, Elizabeth M. Hadac
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Publication number: 20100098632Abstract: This document provides methods and materials related to hydroxyapatite particles. For example, hydroxyapatite particles, methods for making hydroxyapatite particles, and methods for using hydroxyapatite particles are provided herein.Type: ApplicationFiled: July 12, 2007Publication date: April 22, 2010Inventors: Stephen J. Russell, Kah-Whye Peng, Hooi Tin Ong
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Patent number: 7670598Abstract: A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 103 pfus to about 1012 pfus and is delivered by direct injection into a group of cancer cells or via intravenous injection.Type: GrantFiled: June 9, 2008Date of Patent: March 2, 2010Assignee: Mayo Foundation for Medical Education and ResearchInventors: Stephen J. Russell, Adele Kay Fielding, Kah-Whye Peng, Deanna Grote
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Patent number: 7635752Abstract: Control apparatus forcefully stops inverter and inverter when DC/DC converter is anomalously stopped. Additionally, when one of inverters is anomalously stopped while DC/DC converter is normal, control apparatus forcefully stops the other inverter. Then, when a recovery condition is satisfied after the other inverter is forcefully stopped, control apparatus recovers the other inverter.Type: GrantFiled: May 2, 2003Date of Patent: December 22, 2009Assignee: Mayo Foundation for Medical Education and ResearchInventors: Roberto Cattaneo, Sompong Vongpunsawad, Stephen J. Russell, Takafumi Nakamura
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Patent number: 7625742Abstract: The invention provides methods and materials involved in displaying polypeptide sequences using viruses such as avian leukosis viruses. Specifically, the invention provides nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses as well as methods for making nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses. The invention also provides methods for obtaining displayed polypeptide sequences that interact with biological molecules and/or cells as well as methods for identifying biological molecules that interact with displayed polypeptides.Type: GrantFiled: October 8, 2008Date of Patent: December 1, 2009Assignee: Mayo Foundation for Medical Education and ResearchInventors: Mark J. Federspiel, Stephen J. Russell, Pranay D. Khare
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Publication number: 20090155884Abstract: The invention provides methods and materials involved in displaying polypeptide sequences using viruses such as avian leukosis viruses. Specifically, the invention provides nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses as well as methods for making nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses. The invention also provides methods for obtaining displayed polypeptide sequences that interact with biological molecules and/or cells as well as methods for identifying biological molecules that interact with displayed polypeptides.Type: ApplicationFiled: October 8, 2008Publication date: June 18, 2009Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , a Minnesota corporationInventors: Mark J. Federspiel, Stephen J. Russell, Pranay D. Khare
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Patent number: 7449322Abstract: The invention provides methods and materials involved in displaying polypeptide sequences using viruses such as avian leukosis viruses. Specifically, the invention provides nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses as well as methods for making nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses. The invention also provides methods for obtaining displayed polypeptide sequences that interact with biological molecules and/or cells as well as methods for identifying biological molecules that interact with displayed polypeptides.Type: GrantFiled: October 12, 2006Date of Patent: November 11, 2008Assignee: Mayo Foundation for Medical Education and ResearchInventors: Mark J. Federspiel, Stephen J. Russell, Pranay D. Khare
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Patent number: 7132237Abstract: The invention provides methods and materials involved in displaying polypeptide sequences using viruses such as avian leukosis viruses. Specifically, the invention provides nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses as well as methods for making nucleic acid molecules, collections of nucleic acid molecules, polypeptides, collections of polypeptides, viruses, and collections of viruses. The invention also provides methods for obtaining displayed polypeptide sequences that interact with biological molecules and/or cells as well as methods for identifying biological molecules that interact with displayed polypeptides.Type: GrantFiled: March 13, 2002Date of Patent: November 7, 2006Assignee: Mayo Foundation for Medical Education and ResearchInventors: Mark J. Federspiel, Stephen J. Russell, Pranay D. Khare
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Patent number: 6936464Abstract: The invention relates to a nucleic acid construct for delivery into living cells in vivo for inducing an immune response in a patient to an idiotypic determinant present on a malignant B cell in the patient; the construct directing the expression of a fusion protein, said fusion protein comprising the idiotypic determinant and at least one T helper cell epitope from tetanus toxin. The invention further relates to a method of making the nucleic acid construct, a method of treating a patient, and to a composition comprising the nucleic acid construct.Type: GrantFiled: July 18, 1997Date of Patent: August 30, 2005Assignee: Cancer Research Technology LimitedInventors: Delin Zhu, Robert E Hawkins, Stephen J. Russell, Freda K. Stevenson, Gregory P Winter