Abstract: While displaying an application user interface, a device detects a first input to an input device of the one or more input devices, the input device provided on a housing of the device that includes the one or more display generation components. In response to detecting the first input, the device replaces display of at least a portion of the application user interface by displaying a home menu user interface via the one or more display generation components. While displaying the home menu user interface, the device detects a second input to the input device provided on the housing of the device; and in response to detecting the second input to the input device provided on the housing of the device: the device dismisses the home menu user interface.

Abstract: A computer system displays a first object that includes at least a first portion of the first object and a second portion of the first object and detects a first gaze input that meets first criteria, wherein the first criteria require that the first gaze input is directed to the first portion of the first object in order for the first criteria to be met. In response, the computer system displays a first control element that corresponds to a first operation associated with the first object, wherein the first control element was not displayed prior to detecting that the first gaze input met the first criteria, and detects a first user input directed to the first control element. In response to detecting the first user input directed to the first control element, the computer system performs the first operation with respect to the first object.

Abstract: Provided is a compound of formula I, or pharmaceutically acceptable salt or solvate thereof, as defined herein for use in the treatment or prevention of a Dirofilaria infection in a mammal, The compounds are also for use in the treatment or prevention of diseases or conditions caused by a Dirofilaria infection in a mammal. Also described are corresponding methods of treating or preventing a Dirofilaria infection in a mammal.

Abstract: A computer system displays a first application user interface at a first location in a three-dimensional environment. While displaying the first application user interface at the first location in the three-dimensional environment, the computer system detects, at a first time, a first input corresponding to a request to close the first application user interface. In response to detecting the first input corresponding to a request to close the first application user interface: the computer system closes the first application user interface, including ceasing to display the first application user interface in the three-dimensional environment; and, in accordance with a determination that respective criteria are met, the computer system displays a home menu user interface at a respective home menu position that is determined based on the first location of the first application user interface in the three-dimensional environment.

Abstract: In some embodiments, a computer system displays a virtual surface for containing one or more virtual objects in a three-dimensional environment. In some embodiments, a computer system automatically resizes virtual surfaces that contain objects. In some embodiments, a computer system displays feedback related to removal and/or addition of objects to virtual surfaces.

Abstract: Synchronized ion modification systems and techniques are described. An ion modifier can be used to modify a portion of ions that enter a drift chamber via a gate that controls entry of the ions to the drift chamber. A controller that is communicatively coupled to the ion modifier is configured to control the ion modifier to select a portion of the ion to be modified. In embodiments, the controller selects the portion based on a detector's previous response to other ions that are formed from a sample from which the ions were formed. The other ions, for example, correspond to ions that are associated with a peak in previous operation of a spectrometer.

Abstract: Ion modification An ion mobility spectrometer (100) comprising a sample inlet (108) comprising an aperture arranged to allow a sample of gaseous fluid to flow from an ambient pressure region to a low pressure region of the ion mobility spectrometer to be ionised; a controller (200) arranged to control gas pressure in the low pressure region to be lower than ambient pressure; and an ion modifier (126, 127, 202) configured to modify ions in the low pressure region, wherein the ions are obtained from the sample of gas.

Abstract: Synchronized ion modification systems and techniques are provided. An ion modifier can be used to modify a portion of ions that enter a drift chamber via a gate that controls entry of the ions to the drift chamber. A controller that is communicatively coupled to the ion modifier is configured to control the ion modifier to select a portion of the ion to be modified. In embodiments, the controller selects the portion based on a detector's previous response to other ions that are formed from a sample from which the ions were formed. The other ions, for example, correspond to ions that are associated with a peak in previous operation of a spectrometer.

Abstract: Synchronized ion modification systems and techniques are described. An ion modifier can be used to modify a portion of ions that enter a drift chamber via a gate that controls entry of the ions to the drift chamber. A controller that is communicatively coupled to the ion modifier is configured to control the ion modifier to select a portion of the ion to be modified. In embodiments, the controller selects the portion based on a detector's previous response to other ions that are formed from a sample from which the ions were formed. The other ions, for example, correspond to ions that are associated with a peak in previous operation of a spectrometer.

Abstract: Ion modification An ion mobility spectrometer (100) comprising a sample inlet (108) comprising an aperture arranged to allow a sample of gaseous fluid to flow from an ambient pressure region to a low pressure region of the ion mobility spectrometer to be ionised; a controller (200) arranged to control gas pressure in the low pressure region to be lower than ambient pressure; and an ion modifier (126, 127, 202) configured to modify ions in the low pressure region, wherein the ions are obtained from the sample of gas.

Abstract: Synchronized ion modification systems and techniques are described. An ion modifier can be used to modify a portion of ions that enter a drift chamber via a gate that controls entry of the ions to the drift chamber. A controller that is communicatively coupled to the ion modifier is configured to control the ion modifier to select a portion of the ion to be modified. In embodiments, the controller selects the portion based on a detector's previous response to other ions that are formed from a sample from which the ions were formed. The other ions, for example, correspond to ions that are associated with a peak in previous operation of a spectrometer.

Abstract: Synchronized ion modification systems and techniques are described. An ion modifier can be used to modify a portion of ions that enter a drift chamber via a gate that controls entry of the ions to the drill chamber. A controller that is communicatively coupled to the ion modifier is configured to control the ion modifier to select a portion of the ion to be modified. In embodiments, the controller selects the portion based on a detector's previous response to other ions that are formed from a sample from which the ions were formed. The other ions, for example, correspond to ions that are associated with a peak in previous operation of a spectrometer.

Abstract: Synchronized ion modification systems and techniques are described. An ion modifier can be used to modify a portion of ions that enter a drift chamber via a gate that controls entry of the ions to the drill chamber. A controller that is communicatively coupled to the ion modifier is configured to control the ion modifier to select a portion of the ion to be modified. In embodiments, the controller selects the portion based on a detector's previous response to other ions that are formed from a sample from which the ions were formed. The other ions, for example, correspond to ions that are associated with a peak in previous operation of a spectrometer.

Abstract: Synchronized ion modification systems and techniques are described. An ion modifier can be used to modify a portion of ions that enter a drift chamber via a gate that controls entry of the ions to the drift chamber. A controller that is communicatively coupled to the ion modifier is configured to control the ion modifier to select a portion of the ion to be modified. In embodiments, the controller selects the portion based on a detector's previous response to other ions that are formed from a sample from which the ions were formed. The other ions, for example, correspond to ions that are associated with a peak in previous operation of a spectrometer.

Abstract: Synchronized ion modification systems and techniques are described. An ion modifier can be used to modify a portion of ions that enter a drift chamber via a gate that controls entry of the ions to the drift chamber. A controller that is communicatively coupled to the ion modifier is configured to control the ion modifier to select a portion of the ion to be modified. In embodiments, the controller selects the portion based on a detector's previous response to other ions that are formed from a sample from which the ions were formed. The other ions, for example, correspond to ions that are associated with a peak in previous operation of a spectrometer.

Abstract: A cartridge loader for inserting cartridges into a gun magazine. The cartridge loader fits onto a person's thumb and more particularly fits onto the distal phalange of a person's thumb. In one embodiment of the invention, the cartridge loader includes a thumb protecting member and a cartridge-pushing member. The thumb-protecting member defines interior and exterior surfaces and an interior open cavity of sufficient volume and shape to accommodate a distal phalange of a person's thumb. The cartridge-pushing member defines opposite first and second ends. The first end of the cartridge-pushing member is attached to the exterior surface of the thumb-protecting member. The second end of the cartridge-pushing member defines, at least in part, a concave surface to suit the exterior shape of a cartridge casing.

Abstract: A cartridge loader for inserting cartridges into a gun magazine. The cartridge loader fits onto a person's thumb and more particularly fits onto the distal phalange of a person's thumb. In one embodiment of the invention, the cartridge loader includes a thumb protecting member and a cartridge-pushing member. The thumb-protecting member defines interior and exterior surfaces and an interior open cavity of sufficient volume and shape to accommodate a distal phalange of a person's thumb. The cartridge-pushing member defines opposite first and second ends. The first end of the cartridge-pushing member is attached to the exterior surface of the thumb-protecting member. The second end of the cartridge-pushing member defines, at least in part, a concave surface to suit the exterior shape of a cartridge casing.

Abstract: A fluid sampling system has a drift cell (60) enclosing a first fluid. An inlet chamber (62) communicates with the body of first fluid via an orifice (74). A series of negative pressure pulses is applied to the first fluid, causing a sample of a second fluid to be drawn in through the orifice (74). The sample is then entrained into the air flow of a closed loop circulatory system and is detected or measured by an ion mobility spectrometer. A second chamber may be linked to the first chamber, with the negative pressure pulses provided by the second chamber.

Abstract: The present invention reates to a method for detecting activated ras protein. The method includes immobilizing a protein on a solid support, incubating the immobilized protein with lysates from cultured cells, where the lysates include activated ras protein, and determining the amount of activated ras protein bound to the immobilized protein. The present invention also relates to a method of detecting ras oncogenic related malignancy in a human subject.

Abstract: An ion mobility spectrometer includes a spectrometer housing (10) and, within the housing, an ion mobility spectrometer cell (12), a volume of vapour absorbent material (30), and a fan (38) for inducing a flow of recirculating cleaning air through the cell (12) and the absorbent material (30). The vapour absorbent material is held in close proximity with the cell, providing the possibility of constructing a miniature instrument without the need for any external air supply.