Abstract: The present disclosure relates to methods and products for reducing side effects associated with immunotherapy using immune agonist antibodies. In certain embodiments, the present disclosure provides a method of reducing one or more side effects associated with immunotherapy using an immune agonist antibody alone, or in combination with an immune checkpoint inhibitor, in a subject suffering from a cancer, the method comprising modifying the gut microbiota in the subject and thereby reducing the one or more side effects associated with the immunotherapy in the subject.

Abstract: Embodiments of the present invention provide automatic systems and methods for associating objects in databases of a web site by rate-based tagging. The frequencies of users entering specific tag terms for objects stored in the databases of the web site are used to determine hard associations between objects and tag terms and between objects. When the frequencies of user tags exceed established thresholds, hard associations between objects and tag terms are established. When objects are identified or determined to have hard association with tag terms, the objects are determined to be more clearly associated with the corresponding tag terms. Therefore, they should be highlighted or featured in more prominent locations on web pages of the web site to increase users' confidence in content of the web site. To identify hard-associated objects, more weights can be assigned to the hard-associated objects, which allows them to be more likely to be selected for display in prominent locations.

Abstract: Embodiments of the present invention provide systems and methods for automatically generating tag terms (or tags) for objects in databases of a web site. The metadata of the objects (or data) of the web site are processed and parsed to automatically generate tag terms for the corresponding objects. Information (or data, or content) downloaded from the Internet often comes with metadata, which can exist in titles, description, sources, and authors of the information, etc. The metadata of downloaded information can be process and parsed to generate tag terms for the corresponding objects. The system can automatically generate tag terms for the data, which are stored as objects in the databases, and make the data (or objects) searchable. In addition, the automatically generated tag terms allow associated data to maintain their relationship. For example, data from the same sources, same authors, or same subjects can be identified based on the common tag terms.

Abstract: Embodiments of the present invention provide automatic systems and methods for associating objects in databases of a web site by rate-based tagging. The frequencies of users entering specific tag terms for objects stored in the databases of the web site are used to determine hard associations between objects and tag terms and between objects. When the frequencies of user tags exceed established thresholds, hard associations between objects and tag terms are established. When objects are identified or determined to have hard association with tag terms, the objects are determined to be more clearly associated with the corresponding tag terms. Therefore, they should be highlighted or featured in more prominent locations on web pages of the web site to increase users' confidence in content of the web site. To identify hard-associated objects, more weights can be assigned to the hard-associated objects, which allows them to be more likely to be selected for display in prominent locations.

Abstract: Embodiments of the present invention provide systems and methods for automatically generating tag terms (or tags) for objects in databases of a web site. The metadata of the objects (or data) of the web site are processed and parsed to automatically generate tag terms for the corresponding objects. Information (or data, or content) downloaded from the Internet often comes with metadata, which can exist in titles, description, sources, and authors of the information, etc. The metadata of downloaded information can be process and parsed to generate tag terms for the corresponding objects. The system can automatically generate tag terms for the data, which are stored as objects in the databases, and make the data (or objects) searchable. In addition, the automatically generated tag terms allow associated data to maintain their relationship. For example, data from the same sources, same authors, or same subjects can be identified based on the common tag terms.